Growth hormone releasing hormone reverses endotoxin-induced localized inflammatory hyperalgesia without reducing the upregulated cytokines, nerve growth factor and gelatinase activity

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 28, Issue 4, 2004, Pages 625-631

  Talhouk, Rabih S ^a   Saadé, Nayef E ^a   Mouneimne, Ghassan ^a   Masaad, Cynthia A ^a   Safieh Garabedian, Bared ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

central nervous system; CNS; corticotrophin releasing hormone; CRH; Cytokines; ELISA; endotoxin; Enzyme Linked Immunosorbent Assay; ET; Gelatinase B; GH; GHRH; growth hormone; growth hormone releasing hormone; hot plate; HP; HPA; Hyperalgesia; Inflammation; NGF

Indexed keywords

CYTOKINE; ENDOTOXIN; GELATINASE; GELATINASE B; GROWTH HORMONE RELEASING FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; NERVE GROWTH FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; HOT PLATE TEST; HYPERALGESIA; INFLAMMATION; MALE; NONHUMAN; PAIN; PAW EDEMA; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BEHAVIOR, ANIMAL; CYTOKINES; EDEMA; ENDOTOXINS; FOOT; GELATINASES; GROWTH HORMONE-RELEASING HORMONE; HYPERALGESIA; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-1; INTERLEUKIN-6; MALE; NERVE GROWTH FACTORS; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 3342876740     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2004.01.012     Document Type: Article

References (35)

1. Amit Z., Galina Z.H. Stress-induced analgesia: adaptive pain suppression. Physiol. Rev. 66:1986;1091-1120
2. Bozzola M., De Amici M., Zecca M., Schimpff R.M., Rapaport R. Modulating effect of human growth hormone on tumor necrosis factor-α and interleukin-1β Eur. J. Endocrinol. 138:1998;640-643
3. Buckingham J.C. Stress and the neuroendocrine-immune axis: the pivotal role of glucocorticoids and lipocortin 1. Br. J. Pharmacol. 118:1996;1-19
4. Carlton S.M., Du J., Zhou S., Coggeshall R. Tonic control of peripheral cutaneous nociceptors by somatostatin receptors. J. Neurophysiol. 21:2001;4042-4049
5. Chrubasik J., Meynadier J., Blond S., Scherpereel P., Ackerman E., Weinstock M., Bonath K., Cramer H., Wunsch E. Somatostatin, a potent analgesic. Lancet. 2:1984;1208-1209
6. Coleman E.S., Elsasser T.H., Kempianen R.J., Coleman D.S., Sartin J.L. Effect of endotoxin on pituitary hormone secretion in sheep. Neuroendocrinology. 58:1993;111-122
7. Corsi M.M., Ticozzi C., Netti C., Fulgenzi A., Tiengo M., Gaja G., Guidobono F., Ferrero M.E. The effect of somatostatin on experimental inflammation in rats. Anesth. Analg. 85:1997;1112-1125
8. Dadoun F., Guillaume V., Sauze N., Farisse J., Velut J.G., Orsoni J.C., Gaillard R., Oliver C. Effect of endotoxin on the hypothalamus pituitary axis in sheep. Eur. J. Endocrinol. 138:1998;193-197
9. Dray A. Inflammatory mediators of pain. Br. J. Anaesth. 75:1995;125-131
10. Elliott S., Cawston T. The clinical potential of matrix metalloproteinase inhibitors in the rheumatic disorders. Drugs Aging. 18:2001;87-99
11. Honegger J., Spagnoli A., D'Urso R., Navarra P., Tgagarakis S., Bessser G.M., Grossman A.B. Interleukin-1 beta modulates the acute release of growth hormone-releasing hormone and somatostatin from rat hypothalamus in vitro, where as tumor necrosis factor and interleukin-6 had no effect. Endocrinology. 129:1991;1275-1282
12. Jarrar D., Wolf S.E., Jeschke M.G., Ramirez R.J., DebRoy M., Ogle C.K., Papaconstaninou J., Herndon D.N. Growth hormone attenuates the acute-phase response to thermal injury. Arch. Surg. 132:1997;1171-1175
13. Jozsa R., Korf H.W., Merchenthaler I. Growth hormone-releasing factor (GRF)-like immunoreactivity in sensory ganglia of the rat. Cell Tissue Res. 247:1987;441-444
14. Kanaan S., Saadé N.E., Haddad J.J., Abdelnoor A.M., Jabbur S.J., Safieh-Garabedian B. Endotoxin-induced local inflammation and hyperalgesia in rats and mice: a new model for inflammatory pain. Pain. 66:1996;373-379
15. Kanaan S.A., Safieh-Garabedian B., Haddad J.J., Atweh S.F., Abdelnoor A.M., Jabbur S.J., Saadé N.E. Effects of various analgesic and anti-inflammatory drugs on endotoxin-induced hyperalgesia in rats and mice. Pharmacology. 54:1997;285-297
16. Kasting N.M., Martin J.B. Altered release of growth hormone and thyrotropin induced by endotoxin in the rat. Am. J. Physiol. 243:1982;E322-E337
17. Lang C.H., Pollard V., Fan J., Traber L.D., Traber D.L., Frost R.A., Gelato M.C., Prough D.S. Acute alterations in growth hormone-insulin-like growth factor axis in humans injected with endotoxin. Am. J. Physiol. 273:1997;R371-R378
18. Lariviere W.R., Melzack R. The role of corticotropin-releasing factor in pain and analgesia. Pain. 84:2000;1-12
19. Leal-Cerro A., Povedano J., Astorga R., Gonzalez M., Silva H., Garcia-Pesquera F., Casanueva F., Dieguez C. The growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-1 axis in patients with fibromyalgia syndrome. J. Clin. Endocrinol. Metab. 84:1999;3378-3381
20. Marshall L., Perras B., Fehm H.L., Born J. Changes in immune cell counts and interleukin (IL)-1β production in humans after a somnogenically active growth hormone-releasing hormone (GHRH) administration. Brain Behav. Immun. 15:2001;227-234
21. Poole S., Cunha F.Q., Ferreira S.H. Bradykinin, cytokines and inflammatory hyperalgesia. Saadé N.E., Apkarian A.V., Jabbur S.J. Pain and Neuroimmune Interactions. 2000;31-54 Kluwer Academic Publishing/Plenum, New York
22. Priego T., Granado M., Ibanez De Caceres I., Martin A.I., Villanua M.A., Lopez-Calderon A. Endotoxin at low doses stimulates pituitary GH whereas it decreases IGF-I and IGF-binding protein-3 in rats. J. Endocrinol. 179:2003;107-117
23. Priego T., Ibanez De Caceres I., Martin A.I., Villanua M.A., Lopez-Calderon A. Nitric oxide plays a role in endotoxin-induced decreases in circulating IGF-I and IGFBP-3 and their gene expression in the liver. Am. J. Physiol.: Endocrinol. Metab. 286:2004;E50-56
24. Rivier C. Influence of immune signals on the hypothalamic-pituitary axis of the rodent. Front. Neuroendocrinol. 16:1995;151-182
25. Rivier C., Chizzonite R., Vale W. In the mouse, the activation of the hypothalamic-pituitary-adrenal axis by a lipopolysaccharide (endotoxin) is mediated through Interleukin-1. Endocrinology. 125:1989;2800-2805
26. Saadé N.E., Mouneimne G.M., Talhouk R.T., Jabbur S.J., Safieh-Garabedian B. Growth hormone releasing hormone (GHRH) prevents the endotoxin-induced hyperalgesia without altering the levels of cytokines. VIth International Congress of Neuroimmunology, Edinburgh, Scotland:2001
27. Safieh-Garabedian B., Poole S., Allchorne A., Winter J., Woolf C.J. Contribution of interleukin-1β to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br. J. Pharmacol. 115:1995;1265-1275
28. Safieh-Garabedian B., Kanaan S.A., Haddad J.J., Abou Jaoude P., Jabbur S.J., Saadé N.E. Involvement of interleukin-1β, nerve growth factor and prostaglandin E2 in endotoxin-induced hyperalgesia. Br. J. Pharmacol. 121:1997;1619-1626
29. Safieh-Garabedian B., Dardenne M., Kanaan S.A., Atweh S.F., Jabbur S.J., Saadé N.E. The role of cytokines and prostaglandin-E2 in thymulin induced hyperalgesia. Neuropharmacology. 39:2000;1653-1661
30. Saito H., Inoue T., Fukatsu K., Ming-Tsan L., Inaba T., Fukushima R., Muto T. Growth hormone and the immune response to bacterial infection. Horm. Res. 45:1996;50-54
31. Sandkuhler J., Fu Q.-G., Helmchen C. Spinal somatostatin superfusion in vivo affects activity of cat nociceptive dorsal horn neurons: comparison with spinal morphine. Neuroscience. 34:1990;565-567
32. Scarborough D.E. Cytokine modulation of pituitary hormone secretion. Ann. N. Y. Acad. Sci. 594:1990;169-187
33. Talhouk R.S., Chin J.R., Unemori E.N., Werb Z., Bissell M.J. Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture. Development. 112:1991;439-449
34. Talhouk R.S., Hajjar L., Abou-Gergi R., Simaan C.J., Mouneimne G., Saadé N.E., Safieh-Garabedian B. Functional interplay between gelatinases and hyperalgesia in endotoxin-induced localized inflammatory pain. Pain. 84:2000;397-405
35. Zimmerman M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110