Decreased mutant frequency in embryonic brain of DNA polymerase β null mice

Mutagenesis

Volumn 21, Issue 1, 2006, Pages 55-59

  Niimi, Naoko ^a   Sugo, Noriyuki ^a,d   Aratani, Yasuaki ^a   Gondo, Yoichi ^b   Katsuki, Motoya ^c   Koyama, Hideki ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b RIKEN   (Japan)

^c NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE BETA; MUTANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ESCHERICHIA COLI; GENE DELETION; GENE SEQUENCE; GENE VECTOR; GENOTYPE; LIVER; MOUSE; MOUSE STRAIN; MUTAGENESIS; MUTATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; TRANSGENE; WILD TYPE;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BRAIN; CROSSES, GENETIC; DNA DAMAGE; DNA POLYMERASE BETA; DNA REPAIR; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENETIC VECTORS; GENOTYPE; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; NEURONS; RIBOSOMAL PROTEINS;

ANIMALIA; ESCHERICHIA COLI;

EID: 33344469876     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/gei074     Document Type: Article

References (31)

1. Lindahl,T. (1993) Instability and decay of the primary structure of DNA. Nature, 362, 709-715.
2. Friedberg,E.C. (2003) DNA damage and repair. Nature, 421, 436-440.
3. Seeberg,E., Eide,L. and Bjoras,M. (1995) The base excision repair pathway. Trends Biochem. Sci., 20, 391-397.
4. Wilson,S.H. (1998) Mammalian base excision repair and DNA polymerase beta. Mutat. Res., 407, 203-215.
5. Piersen,C.E., McCullough,A.K. and Lloyd,R.S. (2000) AP lyases and dRPases: commonality of mechanism. Mutat. Res., 459, 43-53.
6. Frosina,G., Fortini,P., Rossi,O., Carrozzino,F., Raspaglio,G., Cox,L.S., Lane,D.P., Abbondandolo,A. and Dogliotti,E. (1996) Two pathways for base excision repair in mammalian cells. J. Biol. Chem., 271, 9573-9578.
7. Klungland,A. and Lindahl,T. (1997) Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). EMBO J., 16, 3341-3348.
8. Tanabe,K., Bohn,E.W. and Wilson,S.H. (1979) Steady-state kinetics of mouse DNA polymerase beta. Biochemistry, 18, 3401-3406.
9. Tanabe,K., Yamaguchi,M., Matsukage,A. and Takahashi,T. (1981) Structural homology of DNA polymerase beta from various mammalian cells. J. Biol. Chem., 256, 3098-3102.
10. Kumar,A., Widen,S.G., Williams,K.R., Kedar,P., Karpel,R.L. and Wilson,S.H. (1990) Studies of the domain structure of mammalian DNA polymerase beta. Identification of a discrete template binding domain. J. Biol. Chem., 265, 2124-2131.
11. Kim,K., Biade,S. and Matsumoto,Y. (1998) Involvement of flap endonuclease 1 in base excision DNA repair. J. Biol. Chem., 273, 8842-8848.
12. Hirose,F., Hotta,Y., Yamaguchi,M. and Matsukage,A. (1989) Difference in the expression level of DNA polymerase beta among mouse tissues: high expression in the pachytene spermatocyte. Exp. Cell Res., 181, 169-180.
13. Nowak,R., Woszczynski,M. and Siedlecki,J.A. (1990) Changes in the DNA polymerase beta gene expression during development of lung, brain, and testis suggest an involvement of the enzyme in DNA recombination. Exp. Cell Res., 191, 51-56.
14. Gu,H., Marth,J.D., Orban,P.C., Mossmann,H. and Rajewsky,K. (1994) Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science, 265, 103-106.
15. Sugo,N., Aratani,Y., Nagashima,Y., Kubota,Y. and Koyama,H. (2000) Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta. EMBO J., 19, 1397-1404.
16. Esposito,G., Texido,G., Betz,U.A., Gu,H., Muller,W., Klein,U. and Rajewsky,K. (2000) Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally. Proc. Natl Acad. Sci. USA, 97, 1166-1171.
17. Sugo,N., Niimi,N., Aratani,Y., Takiguchi-Hayashi,K. and Koyama,H. (2004) p53 deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase β-deficient mice. Mol. Cell. Biol., 24, 9470-9477.
18. Niimi,N., Sugo,N., Aratani,Y. and Koyama,H. (2005) Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis. Cell Death Differ., 12, 184-191.
19. Sobol,R.W., Foley,J.F., Nyska,A., Davidson,M.G. and Wilson,S.H. (2003) Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice. DNA Repair (Amst), 2, 609-622.
20. Canitrot,Y., Cazaux,C., Frechet,M., Bouayadi,K., Lesca,C., Salles,B. and Hoffmann,J.S. (1998) Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs. Proc. Natl Acad. Sci. USA, 95, 12586-12590.
21. Sobol,R.W., Watson,D.E., Nakamura,J., Yakes,F.M., Hou,E., Horton,J.K., Ladapo,J., Van Houten,B., Swenberg,J.A., Tindall,K.R., Samson,L.D. and Wilson,S.H. (2002) Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proc. Natl Acad. Sci. USA, 99, 6860-6865.
22. Cabelof,D.C., Guo,Z., Raffoul,J.J., Sobol,R.W., Wilson,S.H., Richardson,A. and Heydari,A.R. (2003) Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens. Cancer Res., 63, 5799-5807.
23. Gondo,Y., Shioyama,Y., Nakao,K. and Katsuki,M. (1996) A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice. Mutat. Res., 360, 1-14.
24. Egashira,A., Yamauchi,K., Yoshiyama,K., Kawate,H., Katsuki,M., Sekiguchi,M., Sugimachi,K., Maki,H. and Tsuzuki,T. (2002) Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes. DNA Repair (Amst), 1, 881-893.
25. Levine,A.J. (1997) p53, the cellular gatekeeper for growth and division. Cell, 88, 323-331.
26. Rockwood,L.D., Nussenzweig,A. and Janz,S. (2003) Paradoxical decrease in mutant frequencies and chromosomal rearrangements in a transgenic lacZ reporter gene in Ku80 null mice deficient in DNA double strand break repair. Mutat. Res., 529, 51-58.
27. Oka,A., Takashima,S., Abe,M., Araki,R. and Takeshita,K. (2000) Expression of DNA-dependent protein kinase catalytic subunit and Ku80 in developing human brains: implication of DNA-repair in neurogenesis. Neurosci. Lett., 292, 167-170.
28. Kunkel,T.A. (1993) Nucleotide repeats. Slippery DNA and diseases. Nature, 365, 207-208.
29. Fujii,S., Akiyama,M., Aoki,K., et al. (1999) DNA replication errors produced by the replicative apparatus of Escherichia coli. J. Mol. Biol., 289, 835-850.
30. Blanca,G., Villani,G., Shevelev,I., Ramadan,K., Spadari,S., Hubscher,U. and Maga,G. (2004) Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. Biochemistry, 43, 11605-11615.
31. Bebenek,K., Garcia-Diaz,M., Blanco,L. and Kunkel,T.A. (2003) The frameshift infidelity of human DNA polymerase lambda. Implications for function. J. Biol. Chem., 278, 34685-34690.