Synthesis of pyrido[2,3-d]pyridazines and pyrazino[2,3-d]-pyridazines-novel classes of GABAA receptor benzodiazepine binding site ligands

Tetrahedron Letters

Volumn 47, Issue 13, 2006, Pages 2257-2260

  Mitchinson, Andrew ^a   Blackaby, Wesley P ^a   Bourrain, Sylvie ^a   Carling, Robert W ^a   Lewis, Richard T ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Aza Wadsworth Emmons cyclization; GABAA receptor ligands; Pyrazinopyridazines; Pyridopyridazines

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; PYRIDAZINE DERIVATIVE;

ARTICLE; CYCLIZATION; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HORNER WADSWORTH EMMONS REACTION; SUBSTITUTION REACTION;

EID: 33344464796     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.01.084     Document Type: Article

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11. 3): δ 3.62 (3H, s), 5.67 (2H, s), 7.48 (3H, m), 7.56 (3H, m), 7.63 (2H, m), 7.85 (1H s), 8.13 (2H, m), 8.20 (1H, s), 9.49 (1H, s).
12. H. Brachwitz Z. Chem. 6 1966 313
13. W.J. Coates, and A. McKillop Heterocycles 29 1989 1077
14. C.J. Moody, C.W. Rees, and R. Thomas Tetrahedron 17 1992 3589
15. 6): δ 9.79 (1H, s), 8.18 (2H, m), 8.13 (2H, m), 7.97 (1H, s), 7.58 (6H, m), 5.78 (2H, s), 4.13 (2H, q, J 7.2 Hz), 1.19 (3H, t, J 7.2 Hz).
16. 3H]Ro15-1788 binding, means for n = 3-5.