메뉴 건너뛰기




Volumn 21, Issue 3, 2006, Pages 308-317

The use of levo-carnitine in children with renal disease: A review and a call for future studies

Author keywords

Anemia; Cardiac disease; Carnitine deficiency; Children; Kidney disease

Indexed keywords

APOLIPOPROTEIN A; APOLIPOPROTEIN B; CARNITINE; CHOLESTEROL; ESSENTIAL AMINO ACID; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN; RECOMBINANT ERYTHROPOIETIN; TRIACYLGLYCEROL;

EID: 33244487237     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-005-2085-4     Document Type: Review
Times cited : (28)

References (80)
  • 2
    • 0021024932 scopus 로고
    • Carnitine - Metabolism and functions
    • Bremer J (1983) Carnitine - metabolism and functions. Physiol Rev 63:1420-1480
    • (1983) Physiol Rev , vol.63 , pp. 1420-1480
    • Bremer, J.1
  • 3
    • 70449186411 scopus 로고
    • Carnitine
    • Harris RS, Marrian GF, Thimann DV (eds) Academic, New York
    • Fraenkel G, Friedman S (1957) Carnitine. Harris RS, Marrian GF, Thimann DV (eds) Vitamins and hormones. Academic, New York, pp 73-118
    • (1957) Vitamins and Hormones , pp. 73-118
    • Fraenkel, G.1    Friedman, S.2
  • 4
    • 0001170249 scopus 로고
    • On the absolute configuration of L-carnitine
    • Kaneko T, Yoshida R (1962) On the absolute configuration of L-carnitine. Bull Chem Soc Jpn 35:1153-1155
    • (1962) Bull Chem Soc Jpn , vol.35 , pp. 1153-1155
    • Kaneko, T.1    Yoshida, R.2
  • 5
    • 0017137132 scopus 로고
    • Hepatic synthesis of carnitine from protein-bound trimethyllysine
    • Labadie J, Dunn WA, Aronson NN Jr. (1976) Hepatic synthesis of carnitine from protein-bound trimethyllysine. Biochem J 160:85-96
    • (1976) Biochem J , vol.160 , pp. 85-96
    • Labadie, J.1    Dunn, W.A.2    Aronson Jr., N.N.3
  • 6
    • 0031850838 scopus 로고    scopus 로고
    • Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells
    • Colquhoun A (1998) Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells. Biochem Mol Biol Int 45:331-336
    • (1998) Biochem Mol Biol Int , vol.45 , pp. 331-336
    • Colquhoun, A.1
  • 7
    • 0023832440 scopus 로고
    • Effects of propionate and carnitine on the hepatic oxidation of short- and medium-chain-length fatty acids
    • Brass EP, Beyerinck RA (1988) Effects of propionate and carnitine on the hepatic oxidation of short- and medium-chain-length fatty acids. Biochem J 250:819-825
    • (1988) Biochem J , vol.250 , pp. 819-825
    • Brass, E.P.1    Beyerinck, R.A.2
  • 9
    • 0344200102 scopus 로고    scopus 로고
    • Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy
    • Loster H, Keller T, Grommisch J, Grunder W (1999) Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy. Mol Cell Biochem 200:93-102
    • (1999) Mol Cell Biochem , vol.200 , pp. 93-102
    • Loster, H.1    Keller, T.2    Grommisch, J.3    Grunder, W.4
  • 10
    • 0020663642 scopus 로고
    • Kinetic compartmental analysis of carnitine metabolism in the dog
    • Rebouche CJ, Engel AG (1983) Kinetic compartmental analysis of carnitine metabolism in the dog. Arch Biochem Biophys 220:60-70
    • (1983) Arch Biochem Biophys , vol.220 , pp. 60-70
    • Rebouche, C.J.1    Engel, A.G.2
  • 11
    • 0028102328 scopus 로고
    • Relationship between the coenzyme A and the carnitine pools in human skeletal muscle at rest and after exhaustive exercise under normoxic and acutely hypoxic conditions
    • Friolet R, Hoppeler H, Krahenbuhl S (1994) Relationship between the coenzyme A and the carnitine pools in human skeletal muscle at rest and after exhaustive exercise under normoxic and acutely hypoxic conditions. J Clin Invest 94:1490-1495
    • (1994) J Clin Invest , vol.94 , pp. 1490-1495
    • Friolet, R.1    Hoppeler, H.2    Krahenbuhl, S.3
  • 12
    • 0015800677 scopus 로고
    • Muscle carnitine palmityltransferase deficiency and myoglobinuria
    • DiMauro S, DiMauro PM (1973) Muscle carnitine palmityltransferase deficiency and myoglobinuria. Science 182:929-931
    • (1973) Science , vol.182 , pp. 929-931
    • DiMauro, S.1    DiMauro, P.M.2
  • 13
    • 0016862854 scopus 로고
    • A disorder of muscle lipid metabolism and myoglobinuria. Absence of carnitine palmitoyl transferase
    • Bank WJ, DiMauro S, Bonilla E, Capuzzi DM, Rowland LP (1975) A disorder of muscle lipid metabolism and myoglobinuria. Absence of carnitine palmitoyl transferase. N Engl J Med 292:443-449
    • (1975) N Engl J Med , vol.292 , pp. 443-449
    • Bank, W.J.1    DiMauro, S.2    Bonilla, E.3    Capuzzi, D.M.4    Rowland, L.P.5
  • 14
    • 0033983728 scopus 로고    scopus 로고
    • Cardiomyopathy in childhood, mitochondrial dysfunction, and the role of L-carnitine
    • Winter SC, Buist NR (2000) Cardiomyopathy in childhood, mitochondrial dysfunction, and the role of L-carnitine. Am Heart J [Suppl] 139:S63-S69
    • (2000) Am Heart J , vol.139 , Issue.SUPPL.
    • Winter, S.C.1    Buist, N.R.2
  • 16
    • 0033954046 scopus 로고    scopus 로고
    • Familial carnitine transporter defect: A treatable cause of cardiomyopathy in children
    • Pierpont ME, Breningstall GN, Stanley CA, Singh A (2000) Familial carnitine transporter defect: A treatable cause of cardiomyopathy in children. Am Heart J 139:S96-S106
    • (2000) Am Heart J , vol.139
    • Pierpont, M.E.1    Breningstall, G.N.2    Stanley, C.A.3    Singh, A.4
  • 20
    • 0037000281 scopus 로고    scopus 로고
    • Role of carnitine and fatty acid oxidation and its defects in infantile epilepsy
    • Tein I (2002) Role of carnitine and fatty acid oxidation and its defects in infantile epilepsy. J Child Neurol [Suppl] 17: S57-S82
    • (2002) J Child Neurol , vol.17 , Issue.SUPPL.
    • Tein, I.1
  • 22
    • 84979343747 scopus 로고
    • Carnitine metabolism and usage in chronic dialysis patients
    • Kurtin PS (1990) Carnitine metabolism and usage in chronic dialysis patients. Semin Dial 3:166-170
    • (1990) Semin Dial , vol.3 , pp. 166-170
    • Kurtin, P.S.1
  • 24
    • 0020965905 scopus 로고
    • A comparison of plasma and muscle carnitine levels in patients on peritoneal or hemodialysis for chronic renal failure
    • Moorthy AV, Rosenblum M, Rajaram R, Shug AL (1983) A comparison of plasma and muscle carnitine levels in patients on peritoneal or hemodialysis for chronic renal failure. Am J Nephrol 3:205-208
    • (1983) Am J Nephrol , vol.3 , pp. 205-208
    • Moorthy, A.V.1    Rosenblum, M.2    Rajaram, R.3    Shug, A.L.4
  • 25
    • 0037385059 scopus 로고    scopus 로고
    • The role of carnitine in normal and altered fatty acid metabolism
    • Hoppel C (2003) The role of carnitine in normal and altered fatty acid metabolism. Am J Kidney Dis 41 [Suppl 4]:S4-S12
    • (2003) Am J Kidney Dis , vol.41 , Issue.SUPPL. 4
    • Hoppel, C.1
  • 26
    • 0024261548 scopus 로고
    • Fatty acid oxidation in the myocardium: Effects of parathyroid hormone and CRF
    • Smogorzewski M, Perna AF, Borum PR, Massry SG (1988) Fatty acid oxidation in the myocardium: Effects of parathyroid hormone and CRF. Kidney Int 34:797-803
    • (1988) Kidney Int , vol.34 , pp. 797-803
    • Smogorzewski, M.1    Perna, A.F.2    Borum, P.R.3    Massry, S.G.4
  • 27
    • 0023880133 scopus 로고
    • Carnitine plasma concentrations in 353 metabolically healthy children
    • Schmidt-Sommerfeld E, Werner D, Penn D (1988) Carnitine plasma concentrations in 353 metabolically healthy children. Eur J Pediatr 147:356-360
    • (1988) Eur J Pediatr , vol.147 , pp. 356-360
    • Schmidt-Sommerfeld, E.1    Werner, D.2    Penn, D.3
  • 28
    • 0025336324 scopus 로고
    • Determination of L-carnitine in biological fluids and tissues
    • Deufel T (1990) Determination of L-carnitine in biological fluids and tissues. J Clin Chem Clin Biochem 28:307-311
    • (1990) J Clin Chem Clin Biochem , vol.28 , pp. 307-311
    • Deufel, T.1
  • 31
  • 32
    • 0021710439 scopus 로고
    • Urinary excretion of l-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: Evidence for secondary insufficiency of l-carnitine
    • Chalmers RA, Roe CR, Stacey TE, Hoppel CL (1984) Urinary excretion of l-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: Evidence for secondary insufficiency of l-carnitine. Pediatr Res 18:1325-1328
    • (1984) Pediatr Res , vol.18 , pp. 1325-1328
    • Chalmers, R.A.1    Roe, C.R.2    Stacey, T.E.3    Hoppel, C.L.4
  • 34
    • 0029035063 scopus 로고
    • Pharmacokinetic considerations for the therapeutic use of carnitine in hemodialysis patients
    • Brass EP (1995) Pharmacokinetic considerations for the therapeutic use of carnitine in hemodialysis patients. Clin Ther 17:176-185
    • (1995) Clin Ther , vol.17 , pp. 176-185
    • Brass, E.P.1
  • 35
    • 0021362187 scopus 로고
    • Kinetic compartmental analysis of carnitine metabolism in the human carnitine deficiency syndromes
    • Rebouche CJ, Engel AG (1984) Kinetic compartmental analysis of carnitine metabolism in the human carnitine deficiency syndromes. J Clin Invest 73:857-867
    • (1984) J Clin Invest , vol.73 , pp. 857-867
    • Rebouche, C.J.1    Engel, A.G.2
  • 37
    • 0019860123 scopus 로고
    • Plasma carnitine concentrations and dyslipidemia in children on maintenance hemodialysis
    • Gusmano R, Oleggini R, Perfumo F (1981) Plasma carnitine concentrations and dyslipidemia in children on maintenance hemodialysis. J Pediatr 3:429-432
    • (1981) J Pediatr , vol.3 , pp. 429-432
    • Gusmano, R.1    Oleggini, R.2    Perfumo, F.3
  • 38
    • 0019964941 scopus 로고
    • Effect of dialysis on serum carnitine, free fatty acids, and triglyceride levels in man and the rat
    • Bartel LL, Hussey JL, Shrago E (1982) Effect of dialysis on serum carnitine, free fatty acids, and triglyceride levels in man and the rat. Metabolism 31:944-947
    • (1982) Metabolism , vol.31 , pp. 944-947
    • Bartel, L.L.1    Hussey, J.L.2    Shrago, E.3
  • 40
    • 0021988575 scopus 로고
    • Serum and muscle L-carnitine levels in hemodialyzed patients during and after long-term L-carnitine treatment
    • Vacha GM, Corsi M, Giorcelli G, D'Iddio S, Maccari F (1985) Serum and muscle L-carnitine levels in hemodialyzed patients during and after long-term L-carnitine treatment. Curr Ther Res 37:505-516
    • (1985) Curr Ther Res , vol.37 , pp. 505-516
    • Vacha, G.M.1    Corsi, M.2    Giorcelli, G.3    D'Iddio, S.4    Maccari, F.5
  • 41
    • 0020544896 scopus 로고
    • Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients
    • Bellinghieri G, Savica V, Mallamace A (1983) Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients. Am J Clin Nutr 38:523-531
    • (1983) Am J Clin Nutr , vol.38 , pp. 523-531
    • Bellinghieri, G.1    Savica, V.2    Mallamace, A.3
  • 42
    • 0037379698 scopus 로고    scopus 로고
    • Dialysis-related carnitine disorder and levocarnitine pharmacology
    • Evans A (2003) Dialysis-related carnitine disorder and levocarnitine pharmacology. Am J Kidney Dis 41 [Suppl 4]:S13-S26
    • (2003) Am J Kidney Dis , vol.41 , Issue.SUPPL. 4
    • Evans, A.1
  • 43
    • 0021983358 scopus 로고
    • Plasma and muscle free carnitine deficiency due to renal Fanconi syndrome
    • Bernardini I, Rizzo WB, Dalakas M, Bernar J, Gahl WA (1985) Plasma and muscle free carnitine deficiency due to renal Fanconi syndrome. J Clin Invest 75:1124-1130
    • (1985) J Clin Invest , vol.75 , pp. 1124-1130
    • Bernardini, I.1    Rizzo, W.B.2    Dalakas, M.3    Bernar, J.4    Gahl, W.A.5
  • 46
  • 47
  • 48
    • 0023218430 scopus 로고
    • Effects of L-carnitine on chronic anemia and adenosine triphosphate concentration in hemodialyzed patients
    • Donatelli M, Terrizzi C, Zumro G, Russo V, Bucalo M, Scarpinaro A (1987) Effects of L-carnitine on chronic anemia and adenosine triphosphate concentration in hemodialyzed patients. Curr Ther Res 41:620-624
    • (1987) Curr Ther Res , vol.41 , pp. 620-624
    • Donatelli, M.1    Terrizzi, C.2    Zumro, G.3    Russo, V.4    Bucalo, M.5    Scarpinaro, A.6
  • 49
    • 0025641584 scopus 로고
    • Effect of L-carnitine and acetyl-L-carnitine on the human erythrocyte membrane stability and deformability
    • Arduini A, Rossi M, Mancinelli G, Belfiglio M, Scurti R, Radatti G, Shohet SB (1990) Effect of L-carnitine and acetyl-L-carnitine on the human erythrocyte membrane stability and deformability. Life Sci 47:2395-2400
    • (1990) Life Sci , vol.47 , pp. 2395-2400
    • Arduini, A.1    Rossi, M.2    Mancinelli, G.3    Belfiglio, M.4    Scurti, R.5    Radatti, G.6    Shohet, S.B.7
  • 52
    • 0036192012 scopus 로고    scopus 로고
    • Effects of L-carnitine supplementation in maintenance hemodialysis patients: A systematic review
    • Hurot JM, Cucherat M, Haugh M, Fouque D (2002) Effects of L-carnitine supplementation in maintenance hemodialysis patients: A systematic review. J Am Soc Nephrol 13:708-714
    • (2002) J Am Soc Nephrol , vol.13 , pp. 708-714
    • Hurot, J.M.1    Cucherat, M.2    Haugh, M.3    Fouque, D.4
  • 53
    • 12244254419 scopus 로고    scopus 로고
    • Practice recommendations for the use of L-carnitine in dialysis-related carnitine disorder. National kidney foundation. Carnitine consensus conference
    • Eknoyan G, Latos DL, Lindberg J (2003) Practice recommendations for the use of L-carnitine in dialysis-related carnitine disorder. National kidney foundation. Carnitine consensus conference. Am J Kidney Dis 41:868-876
    • (2003) Am J Kidney Dis , vol.41 , pp. 868-876
    • Eknoyan, G.1    Latos, D.L.2    Lindberg, J.3
  • 55
    • 0026738929 scopus 로고
    • Effect of low doses of L-carnitine on the response to recombinant human erythropoietin in hemodialyzed children: About two cases
    • Berard E, Iordache A (1992) Effect of low doses of L-carnitine on the response to recombinant human erythropoietin in hemodialyzed children: about two cases. Nephron 62:368-369
    • (1992) Nephron , vol.62 , pp. 368-369
    • Berard, E.1    Iordache, A.2
  • 56
    • 10744233706 scopus 로고    scopus 로고
    • The management of anemia in pediatric peritoneal dialysis patients
    • European Pediatric Peritoneal Dialysis Working Group Guidelines by an ad hoc European committee
    • Schroder CH, European Pediatric Peritoneal Dialysis Working Group (2003) The management of anemia in pediatric peritoneal dialysis patients. Guidelines by an ad hoc European committee. Pediatr Nephrol 18:805-809
    • (2003) Pediatr Nephrol , vol.18 , pp. 805-809
    • Schroder, C.H.1
  • 57
    • 0025552652 scopus 로고
    • Clinical use of carnitine. Past, present and future
    • Siliprandi N, Di Lisa F, Menabo R (1990) Clinical use of carnitine. Past, present and future. Adv Exp Med Biol 272:175-181
    • (1990) Adv Exp Med Biol , vol.272 , pp. 175-181
    • Siliprandi, N.1    Di Lisa, F.2    Menabo, R.3
  • 59
    • 0025992458 scopus 로고
    • Effect of L-carnitine supplementation on lipid metabolism of renal failure, dialysis-dependent children and adolescents
    • Bohles H, Michalk D, von Wendt-Goknur E (1991) Effect of L-carnitine supplementation on lipid metabolism of renal failure, dialysis-dependent children and adolescents. Infusionstherapie 18:224-226
    • (1991) Infusionstherapie , vol.18 , pp. 224-226
    • Bohles, H.1    Michalk, D.2    von Wendt-Goknur, E.3
  • 60
    • 0022919258 scopus 로고
    • Serum free carnitine, carnitine esters and lipids in patients on peritoneal dialysis and hemodialysis
    • Wanner C, Forstner-Wanner S, Shaeffer G, Schollmeyer P, Horl WH (1986) Serum free carnitine, carnitine esters and lipids in patients on peritoneal dialysis and hemodialysis. Am J Nephrol: 206-211
    • (1986) Am J Nephrol , pp. 206-211
    • Wanner, C.1    Forstner-Wanner, S.2    Shaeffer, G.3    Schollmeyer, P.4    Horl, W.H.5
  • 61
    • 0033427417 scopus 로고    scopus 로고
    • Continuous ambulatory peritoneal dialysis (CAPD) adequacy influences serum free carnitine level
    • Grzegozewska AE, Mariak I, Dobrowolska-Zachwieja A (1999) Continuous ambulatory peritoneal dialysis (CAPD) adequacy influences serum free carnitine level. Int Urol Nephrol 31:533-540
    • (1999) Int Urol Nephrol , vol.31 , pp. 533-540
    • Grzegozewska, A.E.1    Mariak, I.2    Dobrowolska-Zachwieja, A.3
  • 65
    • 0019864710 scopus 로고
    • Effects of L-carnitine in hemodiaylzed pediatric patients
    • Bacri JL, Lacour B, Tete MJ, Broyer M (1981) Effects of L-carnitine in hemodiaylzed pediatric patients. Kidney Int 20:426
    • (1981) Kidney Int , vol.20 , pp. 426
    • Bacri, J.L.1    Lacour, B.2    Tete, M.J.3    Broyer, M.4
  • 67
    • 0024838209 scopus 로고
    • Effect of low dose supplementation of L-carnitine on lipid metabolism in hemodialyzed children
    • Gloggler A, Bulla M, Furst P (1989) Effect of low dose supplementation of L-carnitine on lipid metabolism in hemodialyzed children. Kidney Int 36 [Suppl 27]:S256-S258
    • (1989) Kidney Int , vol.36 , Issue.SUPPL. 27
    • Gloggler, A.1    Bulla, M.2    Furst, P.3
  • 68
  • 71
    • 17744403230 scopus 로고    scopus 로고
    • Carnitine supplementation improves apolipoprotein B levels in pediatric peritoneal dialysis patients
    • Kosan C, Sever L, Ansoy N, Caliskan S, Kasapcopur O (2003) Carnitine supplementation improves apolipoprotein B levels in pediatric peritoneal dialysis patients. Pediatr Nephrol 18:1184-1188
    • (2003) Pediatr Nephrol , vol.18 , pp. 1184-1188
    • Kosan, C.1    Sever, L.2    Ansoy, N.3    Caliskan, S.4    Kasapcopur, O.5
  • 72
    • 0027453676 scopus 로고
    • Sites of action of carnitine and its derivatives on the cardiovascular system: Interactions with membranes
    • Fritz IB, Arrigoni-Martelli E (1993) Sites of action of carnitine and its derivatives on the cardiovascular system: Interactions with membranes. Trends Pharmacol Sci 14:355-360
    • (1993) Trends Pharmacol Sci , vol.14 , pp. 355-360
    • Fritz, I.B.1    Arrigoni-Martelli, E.2
  • 77
    • 0035011124 scopus 로고    scopus 로고
    • Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients
    • Brass EP, Adler S, Sietsema KE, Hiatt WR, Orlando AM, Amato A (2001) Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients. Am J Kidney Dis 37:1018-1028
    • (2001) Am J Kidney Dis , vol.37 , pp. 1018-1028
    • Brass, E.P.1    Adler, S.2    Sietsema, K.E.3    Hiatt, W.R.4    Orlando, A.M.5    Amato, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.