Leucocyte-depleting arterial line filtration does not reduce myocardial injury assessed by Troponin T during routine coronary artery bypass grafting using crossclamp fibrillation

Perfusion

Volumn 21, Issue 1, 2006, Pages 55-60

  Whitaker, Donald C ^a,f   Stygall, Jan ^a   Harrison, Michael J G ^b   Mackie, Ian J ^c   Kemp, Michael ^d   Hooper, James ^d   Pugsley, Wilfred B ^e,g   Newman, Stanton P ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d ROYAL BROMPTON HOSPITAL   (United Kingdom)

^e MIDDLESEX HOSPITAL   (United Kingdom)

^f ST THOMAS HOSPITAL   (United Kingdom)

^g NEW CROSS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL MARKER; CREATINE KINASE; ELASTASE; TROPONIN T;

ADULT; AGED; ARTICLE; BLOOD FILTRATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; ELECTROCARDIOGRAM; ENZYME BLOOD LEVEL; FEMALE; HEART FIBRILLATION; HEART MUSCLE INJURY; HEART MUSCLE REVASCULARIZATION; HEART PROTECTION; HUMAN; INTERMETHOD COMPARISON; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL COUNT; PERIOPERATIVE PERIOD; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; STANDARD; STATISTICAL SIGNIFICANCE;

CORONARY ARTERY BYPASS; FILTRATION; HEART INJURIES; HUMANS; LYMPHOCYTE DEPLETION; PANCREATIC ELASTASE; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; TIME FACTORS; TROPONIN T;

EID: 33144472347     PISSN: 02676591     EISSN: None     Source Type: Journal    
DOI: 10.1191/0267659106pf847oa     Document Type: Article

References (31)

1. Mahaffey KW, Alpert JS. Cardiac enzyme elevations after cardiac surgery: the cardiologist's perspective. Am Heart J 2001; 141: 321-24.
2. Iyer VS, Russell WJ, Leppard P, Craddock D. Mortality and myocardial infarction after coronary artery surgery. A review of 12,003 patients. Med J Aust 1993; 159: 166-70.
3. Burns RJ, Gladstone PJ, Tremblay PC et al. Myocardial infarction determined by technetium-99m pyrophosphate single-photon tomography complicating elective coronary artery bypass grafting for angina pectoris. Am J Cardiol 1989; 63: 1429-34.
4. Chaitman BR, Alderman EL, Sheffield LT et al. Use of survival analysis to determine the clinical significance of new Q waves after coronary bypass surgery. Circulation 1983; 67: 302-309.
5. Force T, Hibberd P, Weeks G et al. Perioperative myocardial infarction after coronary artery bypass surgery. Clinical significance and approach to risk stratification. Circulation 1990; 82: 903-12.
6. Edmunds LH, Jr. Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg 1998; 66: S12-16.
7. Morse DS, Adams D, Magnani B. Platelet and neutrophil activation during cardiac surgical procedures: impact of cardiopulmonary bypass. Ann Thorac Surg 1998; 65: 691-95.
8. Park JL, Lucchesi BR. Mechanisms of myocardial reperfusion injury. Ann Thorac Surg 1999; 68: 1905-12.
9. Okazaki Y, Cao ZL, Ohtsubo S et al. Leukocyte-depleted reperfusion after long cardioplegic arrest attenuates ischemia-reperfusion injury of the coronary endothelium and myocardium in rabbit hearts. Eur J Cardiothorac Surg 2000; 18: 90-97.
10. Romson JL, Hook BG, Kunkel SL, Abrams GD, Schork MA, Lucchesi BR. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation 1983; 67: 1016-23.
11. Di Salvo C, Louca LL, Pattichis K, Hooper J, Walesby RK. Does activated neutrophil depletion on bypass by leukocyte filtration reduce myocardial damage? A preliminary report. J Cardiovasc Surg (Torino) 1996; 37: 93-100.
12. Hachida M, Hanayama N, Okamura T et al. The role of leukocyte depletion in reducing injury to myocardium and lung during cardiopulmonary bypass. ASAIO J 1995; 41: M291-94.
13. Johnson D, Thomson D, Mycyk T, Burbridge B, Mayers I. Depletion of neutrophils by filter during aortocoronary bypass surgery transiently improves postoperative cardiorespiratory status. Chest 1995; 107: 1253-59.
14. Hiramatsu Y, Koishizawa T, Matsuzaki K, Enomoto Y, Sakakibara Y. Leukocyte-depleted blood cardioplegia reduces cardiac troponin T release in patients undergoing coronary artery bypass grafting. Jpn J Thorac Cardiovasc Surg 2000; 48: 625-31.
15. Palatianos GM, Balentine G, Papadakis EG et al. Neutrophil depletion reduces myocardial reperfusion morbidity. Ann Thorac Surg 2004; 77: 956-61.
16. Roth M, Kraus B, Scheffold T, Reuthebuch O, Klovekorn WP, Bauer EP. The effect of leukocyte-depleted blood cardioplegia in patients with severe left ventricular dysfunction: a randomized, double-blind study. J Thorac Cardiovasc Surg 2000; 120: 642-50.
17. Mair P, Hoermann C, Mair J, Margreiter J, Puschendorf B, Balogh D. Effects of a leucocyte depleting arterial line filter on perioperative proteolytic enzyme and oxygen free radical release in patients undergoing aortocoronary bypass surgery. Acta Anaesthesiol Scand 1999; 43: 452-57.
18. Mihaljevic T, Tonz M, von Segesser LK et al. The influence of leukocyte filtration during cardiopulmonary bypass on postoperative lung function. A clinical study. J Thorac Cardiovasc Surg 1995; 109: 1138-45.
19. Ilmakunnas M, Pesonen EJ, Ahonen J, Ramo J, Siitonen S, Repo H. Activation of neutrophils and monocytes by a leukocyte-depleting filter used throughout cardiopulmonary bypass. J Thorac Cardiovasc Surg 2005; 129: 851-59.
20. Katus HA, Remppis A, Neumann FJ et al. Diagnostic efficiency of troponin T measurements in acute myocardial infarction. Circulation 1991; 83: 902-12.
21. Carrier M, Pellerin M, Perrault LP, Solymoss BC, Pelletier LC. Troponin levels in patients with myocardial infarction after coronary artery bypass grafting. Ann Thorac Surg 2000; 69: 435-40.
22. Whitaker DC, Newman SP, Stygall J, Hope-Wynne C, Harrison MJ, Walesby RK. The effect of leucocyte-depleting arterial line filters on cerebral microemboli and neuropsychological outcome following coronary artery bypass surgery. Eur J Cardiothorac Surg 2004; 25: 267-74.
23. Galloway MJ, Mackie MJ, McVerry BA. Elastase-alpha 1 antitrypsin complexes in acute leukaemia. Thromb Res 1985; 38: 311-20.
24. Brower MS, Harpel PC. Alpha-1-antitrypsin-human leukocyte elastase complexes in blood: quantification by an enzyme-linked differential antibody immunosorbent assay and comparison with alpha-2-plasmin inhibitor-plasmin complexes. Blood 1983; 61: 842-49.
25. Baugh RJ, Travis J. Human leukocyte granule elastase: rapid isolation and characterization. Biochemistry 1976; 15: 836-41.
26. Thurlow PT, Doolan L, Sharp R, Sullivan M, Smith B, Andersen LW. Laboratory studies of the effect of Pall extracorporeal leucocyte filters LG6 and AV6 on patients undergoing coronary bypass grafts. Perfusion 1996; 11: 29-37.
27. Koh TW, Carr-White GS, DeSouza AC et al. Intraoperative cardiac troponin T release and lactate metabolism during coronary artery surgery: comparison of beating heart with conventional coronary artery surgery with cardiopulmonary bypass. Heart 1999; 81: 495-500.
28. Krejca M, Skiba J, Szmagala P, Gburek T, Bochenek A. Cardiac troponin T release during coronary surgery using intermittent cross-clamp with fibrillation, on-pump and off-pump beating heart. Eur J Cardiothorac Surg 1999; 16: 337-41.
29. Taggart DP. Biochemical assessment of myocardial injury after cardiac surgery: effects of a platelet activating factor antagonist, bilateral internal thoracic artery grafts, and coronary endarterectomy. J Thorac Cardiovasc Surg 2000; 120: 651-59.
30. Remppis A, Scheffold T, Greten J et al. Intracellular compartmentation of troponin T: release kinetics after global ischemia and calcium paradox in the isolated perfused rat heart. J Mol Cell Cardiol 1995; 27: 793-803.
31. Rottbauer W, Gretan T, Muller-Bardorff M et al. Troponin T: a diagnostic marker for myocardial infarction and minor cardiac cell damage. Eur Heart J 1996; 17 Suppl F: 3-8.