Relevance of ventricular electrical dispersion to arrhythmogenesis in ischemic myocardium - A simulation study

General Physiology and Biophysics

Volumn 24, Issue 4, 2005, Pages 365-380

  Zhang, H ^a,b   Zhang, Zhenxi X ^a   Yang, L ^b   Jin, Y B ^a,b   Huang, Y Z ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Arrhythmia; Computer simulations; Ischemia; Reentries; Refractoriness

Indexed keywords

DELAYED RECTIFIER POTASSIUM CHANNEL; POTASSIUM CHANNEL; POTASSIUM ION; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ACIDOSIS; ANOXIA; ARRHYTHMOGENESIS; ARTICLE; COMPUTER SIMULATION; EXTRACELLULAR SPACE; EXTRASYSTOLE; HEART CYCLE; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART VENTRICLE; ION CURRENT; MATHEMATICAL ANALYSIS; MUSCLE ACTION POTENTIAL; PROCESS MODEL; REENTRY TACHYCARDIA; SODIUM CALCIUM EXCHANGE;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIA; COMPUTER SIMULATION; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HUMANS; MODELS, CARDIOVASCULAR; MYOCARDIAL ISCHEMIA; POTASSIUM; POTASSIUM CHANNELS;

EID: 33144471891     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Aoxiang X., Michael R. G. (1998): Two forms of spiral-wave reentry in an ionic model of ischemic ventricular myocardium. Chaos 8, 157-175
2. Beeler G. W., Reuter H. (1977): Reconstruction of the action potential of ventricular myocardial fibres. J. Physiol. (London) 268, 177-210
3. Biktashev V. N., Holden A. V. (1998): Re-entrant waves and their elimination in a model of mammalian ventricular tissue. Chaos 8, 48-56
4. Biktashev V. N., Holden A. V., Mironov S. F., Pertsov A. M., Zaitsev A. V. (2002): Three dimensional organization of re-entrant propagation during experimental ventricular fibrilation. Chaos Soliton Fractals 13, 1713-1733
5. Carmeliet E. (1999): Cardiac ionic currents and acute ischemia: from channels to arrhythmias. Physiol. Rev79, 917-1017.
6. Cascio W.E. (2001): Myocardial ischemia: what factors determine arrhythmogenesis? J. Cardiovasc. Electrophysiol. 12, 726-729
7. Chen P. S., Wu T. J., Ting C. T., Karagueuzian H. S., Garfinkel A., Lin S. F., Weiss J. N. (2003): A tale of two fibrillations. Circulation 108, 2298-2303
8. Clayton R. H., Parkinson K., Holden A. V. (2002): Re-entry in computer models of ischaemic myocardium. Chaos Sohton Ractals 13, 1671-1683
9. Fast V. G., Pertsov A. M. (1992): Shift and termination of functional reentry in isolated ventricular preparations with quinidine-induced inhomogeneity in refractory period. J. Cardiovasc. Electrophysiol. 3, 255-265
10. Irisawa H., Sato R. (1986): Intra- and extracellular actions of proton on the calcium current of isolated guinea pig ventricular cells. Circ. Res. 59, 348-355
11. Janse M. J. (1992): The premature beat. Cardiovasc. Res. 26, 89-100
12. Jin Y. B., Yang L., Zhang H., Kuo Y. H., Huang Y. Z., Jiang D. Z. (2004): Numerical algorithm for conduction of action potential in two-dimensional cardiac ventricular tissue. Journal of Xi'an Jiaotong University 38, 851-854 (in Chinese)
13. Luo C. H., Rudy Y. (1991): A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circ. Res. 68, 1501-1523
14. Luo C. H., Rudy Y. (1994): A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ. Res. 74, 1071-1096
15. Noble D., Noble S. J., Bett G. C. L. (1991): The role of sodium-calcium exchange during the cardiac action potential. Ann. N. Y. Acad. Sci. 639, 334-353
16. Ks, and length- and tension-dependent processes. Can. J. Cardiol. 14, 123-134
17. + channels in cardiac muscle. Nature 305, 147-149
18. Qu Z., Garfinkel A. (1999): An advanced algorithm for solving partial differential equation in cardiac conduction. IEEE Trans. Biomed. Eng. 46, 1166-1168
19. Qu Z., Weiss J. N., Garfinkel A. (1999): Cardiac electrical restitution properties and the stability of reentrant spiral waves: a simulation study. Am. J. Physiol. 276, 269-283
20. Qu Z., Xie F. G., Garfinkel A., Weiss J. N. (2000): Origins of spiral wave meander and breakup in a two-dimensional cardiac tissue model. Ann. Biomed. Eng. 28, 755-771
21. Shaw R. M., Rudy Y. (1997a): Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovasc. Res. 35, 256-272
22. Shaw R. M., Rudy Y. (1997b): Electrophysiologic effects of acute myocardial ischemia: a mechanistic investigation of action potential conduction and conduction failure. Circ. Res. 80, 124-138
23. Starmer C. F., Romashko D. N., Reddy R. S. (1995): Proarrhythmic response to potassium channel blockade:numerical studies of polymorphic tachyarrhythmias. Circulation 92, 595-605
24. Taggart P., Sutton M. I., Boyett M. R. (1996): Human ventricular action potential duration during short and long cycles-rapid modulation by ischemia. Circulation 94, 2526-2534
25. Tsunetoyo N., Takashi A., Kazuo N., Tohru O. (2000): Spatial heterogeneity in refractoriness as a proarrhythmic substrate - theoretical evaluation by numerical simulation. Jpn. Circ. J. 64, 121-129
26. Viswanathan P. C., Shaw R. M., Rudy Y. (1999): Effect of Ikr and Iks heterogeneity on action potential duration and its rate dependence. Circulation 99, 2466-2485
27. Wu T. J., Lin S. F. (2002): Two types of VF in isolated rabbit hearts: importance of excitability and action potential duration restitution. Circulation 106, 1859-1866
28. Winfree A. T. (1994): Electrical turbulence in three-dimensional heart muscle. Science 222, 1003-1006
29. Xie F. C., Qu Z. L., Garfinkel A., Weiss J. N. (2001): Effects of simulated ischemia on spiral wave stability. Am. J. Physiol., Heart. Circ. Physiol. 280, H1667-1673