A novel N-chlorotaurine-corticosteroid combination as a preservative-free local disinfectant: Influence on the ciliary beat frequency in vitro

Acta Oto-Laryngologica

Volumn 126, Issue 3, 2006, Pages 291-294

  Arnitz, Roland ^a   Ott, Helmut Werner ^a   Gstöttner, Michaela ^a   Nagl, Markus ^a   Scholtz, Arne W ^a   Neher, Andreas ^a,b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

Benzalkonium chloride; Fluticasone propionate; Human ciliated cells; In vitro study

Indexed keywords

BENZALKONIUM; CORTICOSTEROID; FLUTICASONE PROPIONATE; N CHLOROTAURINE; TAURINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CILIARY MOTILITY; COMPUTER ANALYSIS; DISINFECTION; DRUG EFFECT; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MICROSCOPY; PHOTOMETRY; PRIORITY JOURNAL;

ANDROSTADIENES; ANTI-INFECTIVE AGENTS, LOCAL; CELLS, CULTURED; CILIA; DISINFECTANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; HUMANS; MAXIMUM TOLERATED DOSE; MUCOCILIARY CLEARANCE; NASAL MUCOSA; SENSITIVITY AND SPECIFICITY; TAURINE;

EID: 32944477729     PISSN: 00016489     EISSN: None     Source Type: Journal    
DOI: 10.1080/00016480500388935     Document Type: Article

References (16)

1. Hofmann T, Gugatschga M, Koidl B, Wolf G. Influence of preservatives and topical steroids on ciliary beat frequency in vitro. Arch Otolaryngol Head Neck Surg 2004;130:440-5.
2. Stelmaszynska T, Zgliczynski JM. Myeloperoxidase of human neutrophilic granulocytes as chlorinating enzyme. Eur J Biochem 1974;45:305-12.
3. Thomas EL, Grisham MB, Jefferson MM. Cytotoxicity of chloramines. Methods Enzymol 1986;132:585-93.
4. Nagl M, Gottardi W. Enhancement of the bactericidal efficacy of N-chlorotaurine by inflammation samples and selected N-H compounds. Hyg Med 1996;21:597-605.
5. Nagl M, Larcher C, Gottardi W. Activity of N-chlorotaurine against herpes simplex and adenoviruses. Antiviral Res 1998;38:25-30.
6. Nagl M, Hengster P, Semenitz E, Gottardi W. The post-antibiotic effect of N-chlorotaurine on Staphylococcus aureus. Application in the mouse peritonitis model. J Antimicrob Chemother 1999;43:805-9.
7. Meltzer EO, Charous BL, Busse WW, Zinreich SJ, Lorber RR, Danzig MR, et al. Added relief in the treatment of acute recurrent sinusitis with adjuvant mometason furoate nasal spray. J Allergy Clin Immunol 2000;106:630-7.
8. Meltzer EO, Orgel HA, Backhaus JW, Busse WW, Druce HM, Metzger WJ, et al. Intranasal flunisolide spray as an adjunct to oral antibiotic therapy for sinusitis. J Allergy Clin Immunol 1993;92:812-23.
9. Barlan IB, Erkan E, Bakir M, Berrak S, Basaran MM. Intranasal budesonide spray as an adjunct to oral antibiotic therapy for acute sinusitis in children. Ann Allergy Asthma Immunol 1997;78:598-601.
10. Ingels KJ, Meeuwsen F, van Strien HL, Graamans K, Huizing EH. Ciliary beat frequency and the nasal cycle. Eur Arch Otorhinolaryngol 1990;248:123-6.
11. Baroody FM, Cheng CC, Moylan B, de Tineo M, Haney L, Reed KD, et al. Absence of nasal mucosal atrophy with fluticasone aqueous nasal spray. Arch Otolaryngol Head Neck Surg 2001;127:193-9.
12. FitzGerald JM, Boulet LP, Follows RM. The CONCEPT trial: a 1-year, multicenter, randomized, double-blind, double-dummy comparison of a stable dosing regimen of salmeterol/fluticasone propionate with an adjustable maintenance dosing regimen of formoterol/budesonide in adults with persistent asthma. Clin Ther 2005;7:393-406.
13. Baena-Cagnani CE. Safety and tolerability of treatments for allergic rhinitis in children. Drug Saf 2004;27:883-98.
14. Verona E, Petrov D, Cserhati E, Hofman J, Geppe N, Medley H, et al. Fluticasone propionate in asthma: a long term dose comparison study. Arch Dis Child 2003;88:503-9.
15. Hofer E, Neher A, Gunkel AR, Nagl M. In vitro study on the influence of N-chlorotaurine on the ciliary beat frequency of nasal mucosa. Am J Rhinol 2003;17:149-52.
16. Gstottner M, Nagl M, Pototschnig C, Neher A. Refractory rhinosinusitis complicating immunosuppression: application of N-chlorotaurine, a novel endogenous antiseptic agent. ORL J Otorhinolaryngol Relat Spec 2003;65:303-5.