A novel LC-IDMS/MS method for the determination of the cardiac glycosides digoxin and digitoxin using caesium adducts

Clinical Laboratory

Volumn 52, Issue 1-2, 2006, Pages 37-42

  Kaiser, Patricia ^a   Akerboom, Theodorus ^b   Wood, William Graham ^a   Reinauer, Hans ^a  

^a Reference Method Laboratories   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC GLYCOSIDE; CESIUM ION; DIGITOXIN; DIGOXIN;

ACCURACY; ARTICLE; CONCENTRATION RESPONSE; COVARIANCE; DISSOCIATION; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; FRAGMENTATION REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; MONITORING; SENSITIVITY AND SPECIFICITY; SIGNAL NOISE RATIO;

CESIUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIGITOXIN; DIGOXIN; MASS SPECTROMETRY;

EID: 32644462784     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Richtlinie der Bundesärztekammer zur Qualitätssicherung quantitativer laboratoriumsmedizinischer Untersuchungen. Deutsches Ärzteblatt 2001; 98: B2356-67
2. Richtlinie der Bundesärztekammer zur Qualitätssicherung quantitativer laboratoriumsmedizinischer Untersuchungen - Mittei-lung. Deutsches Ärzteblatt 2003; 100: B2775-8
3. Kaiser P, Kramer U, Meissner D, Kress M, Wood WG, Reinauer H. Determination of digoxin and digitoxin by liquid chromatography combined with isotope-dilution mass spectrometry (LC-IDMS) - a candidate reference measurement procedure. Clin Lab 2003; 49: 329-43
4. Kessler A. Massenspektrometrische Isotopenverdünnungsanalyse von Digoxin und Digitoxin in menschlichem Serum - Referenzmethode in der klinischen Chemie. Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms Universität Bonn(2001
5. Fierens C, Stöckl D, Thienpont LM, de Leenbeer AP. Strategies for determination of insulin with electrospray mass spectrometry: Implications for other analyte proteins? Rapid Commun Mass Spectrum 2001; 15: 1433-41
6. Kaiser P, Akerboorn T, Wood WG, Reinauer H. A new approach for the determination of immunosuppressive drugs in whole blood using HPLC-MS/MS and caesium-adducts. Ger. Med. Sci. Submitted for publication.