A preadipocyte differentiation assay as a method for screening potential anti-type II diabetes drugs from herbal extracts

Planta Medica

Volumn 72, Issue 1, 2006, Pages 14-19

  Xu, Ming En ^a   Xiao, Shang Zhi ^a   Sun, Yong Hong ^a   Ou Yang, Yang ^a   Guan, Chen ^a   Zheng, Xiao Xiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; Endothelial cells; Glucose uptake; PPAR ; Preadipocytes; Type II diabetes

Indexed keywords

ANTIDIABETIC AGENT; ASTRAGALOSIDE IV; GLUCOSE; HERBACEOUS AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; PUERARIN; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CHINESE HERB; COMPUTER ANALYSIS; CONTROLLED STUDY; DRUG SCREENING; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORT; MALE; MORPHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROADIPOCYTE; QUANTITATIVE ANALYSIS; RAT; VALIDATION PROCESS;

ADIPOCYTES; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; HUMANS; HYPOGLYCEMIC AGENTS; MALE; PLANT EXTRACTS; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; THIAZOLIDINEDIONES;

ANIMALIA;

EID: 32644453577     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-916215     Document Type: Article

References (28)

1. Taylor SI. Deconstructing type 2 diabetes. Cell 1999; 97: 9-12
2. DeFronzo RA. Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 2004; 88: 787-835
3. Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-43
4. Steppan CM, Lazar MA. Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab 2002; 13: 18-23
5. Wajchenberg BL, Malerbi DA, Rocha MS, Lerario AC, Santomauro AT. Syndrome X: a syndrome of insulin resistance. Epidemiological and clinical evidence. Diabetes Metab Rev 1994; 10: 19-29
6. Verspohl EJ. Recommended testing in diabetes research. Planta Med 2002; 68: 581-90
7. Hayashi T, Maruyama H, Kasai R, Hattori K, Takasuga S, Hazeki O et al. Ellagitannins from Lagerstroemia speciosa as activators of glucose transport in fat cells. Planta Med 2002; 68: 173-5
8. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM et al. The hormone resistin links obesity to diabetes. Nature 2001; 409: 307-12
9. Trayhurn P, Beattie JH. Physiological role of adipose tissue: White adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 2001; 60: 329-39
10. Gregoire FM, Smas CM, Sul HS. Understanding adipocyte differentiation. Physiol Rev 1998; 78: 783-809
11. Okuno A, Tamemoto H, Tobe K. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest 1998; 101: 1354-61
12. Dandona P, Aljada A. Endothelial dysfunction in patients with type 2 diabetes and the effects of thiazolidinedione antidiabetic agents. J Diabet Complications 2004; 18: 91-102
13. Balletshofer BM, Rittig K, Enderle MD, Volk A, Maerker E, Jacob S et al. Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance. Circulation 2000; 101: 1780-4
14. Rodbell M. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem 1964; 239: 375-80
15. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973; 52: 2745-56
16. Ramirez ZJL, Castro MF, Kuri HW. Quantitation of adipose conversion and triglycerides by staining intracyctoplasmic lipids with Oil red O. Histochemistry 1992; 97: 493-7
17. Hutley LJ, Newell FM, Joyner JM, Suchting SJ, Herington AC, Cameron DP et al. Effects of rosiglitazone and linoleic acid on human preadipocyte differentiation. Eur J Clin Invest 2003; 33: 574-81
18. Jiang G, Dallas-Yang Q, Biswas S, Li Z, Zhang BB. Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARgamma), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo. Biochem J 2004; 377: 339-46
19. Iijima K, Yoshizumi M, Ako J, Eto M, Kim S, Hashimoto M et al. Expression of peroxisome proliferator-activated receptor γ(PPAR γ) in rat aortic smooth muscle cells. Biochem Biophys Res Commun 1998; 247: 353-6
20. Gonzalez-Yanes C, Sanchez-Margalet V. Pancreastatin modulates insulin signaling in rat adipocytes: mechanisms of cross-talk. Diabetes 2000; 49: 1288-94
21. Olefsky JM. Mechanisms of the ability of insulin to activate the glucose-transport system in rat adipocytes. Biochem J 1978; 172: 137-45
22. Fukunaga Y, Itoh H, Doi K, Tanaka T, Yamashita J, Chun TH et al. Thiazolidinediones, peroxisome proliferator-activated receptor γ agonists, regulate endothelial cell growth and secretion of vasoactive peptides. Atherosclerosis 2001; 158: 113-9
23. Spyridopoulos I, Brogi E, Kearney M, Sullivan AB, Cetrulo C, Isner JM et al. Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-á: balance between growth and death signals. J Mol Cell Cardiol 1997; 29: 1321-30
24. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis: Flow cytometric detection of phosphatidylserine expression on early apoptosis cells using fluorescein labeled annexin V. J Immunol Methods 1995; 184: 39-51
25. Fujiwara T, Horikoshi H. Troglitazone and related compounds: therapeutic potential beyond diabetes. Life Sci 2000; 67: 2405-16
26. Rosen ED, Spiegelman BM. PPARgamma: A nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem 2001; 276: 37731-4
27. 12 cells of mice. Planta Med 2002; 68: 999-1003
28. Song XP, Chen PP, Chai XS. Effects of puerarin on blood pressure and plasma renin activity in spontaneously hypertensive rats. Zhongguo Yao Li Xue Bao 1988; 9: 55-8