Synaptotagmin IV does not alter excitatory fast synaptic transmission or fusion pore kinetics in mammalian CNS neurons

Journal of Neuroscience

Volumn 26, Issue 2, 2006, Pages 372-380

  Ting, Jonathan T ^a   Kelley, Brooke G ^a   Sullivan, Jane M ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium dependence; Fusion pore kinetics; Kiss and run; Paired pulse depression; Short term plasticity; Synaptic release probability

Indexed keywords

CALCIUM; SYNAPTOTAGMIN; SYNAPTOTAGMIN IV; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CALCIUM TRANSPORT; CELL CULTURE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; GENE OVEREXPRESSION; HIPPOCAMPUS; KINETICS; MAMMAL CELL; MOUSE; NEUROTRANSMISSION; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; PROTEIN FUNCTION; SENSOR; SYNAPTIC TRANSMISSION;

AMINO ACID SUBSTITUTION; ANIMALS; CALCIUM; CELLS, CULTURED; EXOCYTOSIS; HIPPOCAMPUS; MICE; NEURONAL PLASTICITY; NEURONS; NEUROTRANSMITTER AGENTS; PATCH-CLAMP TECHNIQUES; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT FUSION PROTEINS; SYNAPTIC TRANSMISSION; SYNAPTIC VESICLES; SYNAPTOTAGMIN I; SYNAPTOTAGMINS;

EID: 32544439495     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3997-05.2006     Document Type: Article

References (33)

1. Adolfsen B, Saraswati S, Yoshihara M, Littleton JT (2004) Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment. J Cell Biol 166:249-260.
2. Aravanis AM, Pyle JL, Tsien RW (2003) Single synaptic vesicles fusing transiently and successively without loss of identity. Nature 423:643-647.
3. Bekkers JM, Stevens CF (1991) Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture. Proc Natl Acad Sci USA 88:7834-7838.
4. Choi S, Klingauf J, Tsien RW (2000) Postfusional regulation of cleft glutamate concentration during LTP at 'silent synapses.' Nat Neurosci 3:330-336.
5. Choi S, Klingauf J, Tsien RW (2003) Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation. Philos Trans R Soc Lond B Biol Sci 358:695-705.
6. Dodge Jr FA, Rahamimoff R (1967) Co-operative action of calcium ions in transmitter release at the neuromuscular junction. J Physiol (Lond) 193:419-432.
7. Ferguson GD, Thomas DM, Elferink LA, Herschman HR (1999) Synthesis, degradation, and subcellular localization of synaptotagmin IV, a neuronal immediate early gene product. J Neurochem 72:1821-1831.
8. Ferguson GD, Anagnostaras SG, Silva AJ, Herschman HR (2000) Deficits in memory and motor performance in synaptotagmin IV mutant mice. Proc Natl Acad Sci USA 97:5598-5603.
9. Ferguson GD, Wang H, Herschman HR, Storm DR (2004) Altered hippocampal short-term plasticity and associative memory in synaptotagmin IV (-/-) mice. Hippocampus 14:964-974.
10. Fernandez-Chacon R, Konigstorfer A, Gerber SH, Garcia J, Matos MF, Stevens CF, Brose N, Rizo J, Rosenmund C, Sudhof TC (2001) Synaptotagmin I functions as a calcium regulator of release probability. Nature 410:41-49.
11. Han W, Rhee JS, Maximov A, Lao Y, Mashimo T, Rosenmund C, Sudhof TC (2004) N-glycosylation is essential for vesicular targeting of synaptotagmin 1. Neuron 41:85-99.
12. Ibata K, Hashikawa T, Tsuboi T, Terakawa S, Liang F, Mizutani A, Fukuda M, Mikoshiba K (2002) Non-polarized distribution of synaptotagmin IV in neurons: evidence that synaptotagmin IV is not a synaptic vesicle protein. Neurosci Res 43:401-406.
13. Kim J, Alger BE (2001) Random response fluctuations lead to spurious paired-pulse facilitation. J Neurosci 21:9608-9618.
14. Klyachko VA, Jackson MB (2002) Capacitance steps and fusion pores of small and large-dense-core vesicles in nerve terminals. Nature 418:89-92.
15. Littleton JT, Serano TL, Rubin GM, Ganetzky B, Chapman ER (1999) Synaptic function modulated by changes in the ratio of synaptotagmin I and IV. Nature 400:757-760.
16. Machado HB, Liu W, Vician LJ, Herschman HR (2004) Synaptotagmin IV overexpression inhibits depolarization-induced exocytosis in PC12 cells. J Neurosci Res 76:334-341.
17. Mennerick S, Zorumski CF (1995) Paired-pulse modulation of fast excitatory synaptic currents in microcultures of rat hippocampal neurons. J Physiol (Lond) 488:85-101.
18. Pawlu C, DiAntonio A, Heckmann M (2004) Postfusional control of quantal current shape. Neuron 42:607-618.
19. Rahamimoff R, Fernandez JM (1997) Pre- and postfusion regulation of transmitter release. Neuron 18:17-27.
20. Richards DA, Bai J, Chapman ER (2005) Two modes of exocytosis at hippocampal synapses revealed by rate of FM1-43 efflux from individual vesicles. J Cell Biol 168:929-939.
21. Robinson IM, Ranjan R, Schwarz TL (2002) Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain. Nature 418:336-340.
22. 2+. J Gen Physiol 122:265-276.
23. Stevens CF, Sullivan JM (2003) The synaptotagmin C2A domain is part of the calcium sensor controlling fast synaptic transmission. Neuron 39:299-308.
24. Stevens CF, Williams JH (2000) "Kiss and run" exocytosis at hippocampal synapses. Proc Natl Acad Sci USA 97:12828-12833.
25. Sullivan JM (1999) Mechanisms of cannabinoid-receptor-mediated inhibition of synaptic transmission in cultured hippocampal pyramidal neurons. J Neurophysiol 82:1286-1294.
26. Tocco G, Bi X, Vician L, Lim IK, Herschman H, Baudry M (1996) Two synaptotagmin genes, Syt1 and Syt4, are differentially regulated in adult brain and during postnatal development following kainic acid-induced seizures. Brain Res Mol Brain Res 40:229-239.
27. Ullrich B, Li C, Zhang JZ, McMahon H, Anderson RG, Geppert M, Sudhof TC (1994) Functional properties of multiple synaptotagmins in brain. Neuron 13:1281-1291.
28. Vician L, Lim IK, Ferguson G, Tocco G, Baudry M, Herschman HR (1995) Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain. Proc Natl Acad Sci USA 92:2164-2168.
29. Virmani T, Han W, Liu X, Sudhof TC, Kavalali ET (2003) Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling. EMBO J 22:5347-5357.
30. 2+ binding. J Biol Chem 272:14314-14319.
31. Wang CT, Grishanin R, Earles CA, Chang PY, Martin TF, Chapman ER, Jackson MB (2001) Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles. Science 294:1111-1115.
32. Wang CT, Lu JC, Bai J, Chang PY, Martin TF, Chapman ER, Jackson MB (2003) Different domains of synaptotagmin control the choice between kiss-and-run and full fusion. Nature 424:943-947.
33. Zhang Q, Fukuda M, Van Bockstaele E, Pascual O, Haydon PG (2004) Synaptotagmin IV regulates glial glutamate release. Proc Natl Acad Sci USA