A review of the reference dose for chlorpyrifos

Regulatory Toxicology and Pharmacology

Volumn 44, Issue 2, 2006, Pages 111-124

  Zhao, Qiyu ^a   Dourson, Michael ^a   Gadagbui, Bernard ^a  

^a Toxicology Excellence for Risk Assessment   (United States)

Author keywords

ChE inhibition; Chlorpyrifos; Fetal development; Reference Dose; Risk assessment

Indexed keywords

CHLORPYRIFOS; CHOLINESTERASE;

ARTICLE; BRAIN; BRAIN DEVELOPMENT; CHOLINESTERASE INHIBITION; DOSE RESPONSE; FETUS WEIGHT; HUMAN; MEDICAL LITERATURE; NONHUMAN; PRIORITY JOURNAL; PUBLICATION; REFERENCE VALUE; RISK ASSESSMENT; TOXICITY TESTING; WEIGHT REDUCTION;

ANIMALS; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDEMIOLOGIC STUDIES; ERYTHROCYTES; HUMANS; INSECTICIDES; NO-OBSERVED-ADVERSE-EFFECT LEVEL; REFERENCE VALUES; RISK ASSESSMENT;

ANIMALIA;

EID: 32544436086     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yrtph.2005.10.003     Document Type: Article

References (60)

1. J.E. Aldridge, F.J. Seidler, A. Meyer, I. Thillai, and T.A. Slotkin Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods Environ. Health Perspect. 111 14 2003 1736 1743
2. G. Amitai, D. Moorad, R. Adani, and B.P. Doctor Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon Biochem. Pharmacol. 56 1998 293 299
3. ATSDR (Agency for Toxic Substances and Disease Registry), 1997. Toxicological Profile for Chlorpyrifos. U.S. Department of Health & Human Services, Public Health Service, Atlanta, GA.
4. Barker, M.H., 1989. Chlorpyrifos oral toxicity study in Beagle dogs (repeated daily dosage for 13 weeks. Unpublished report from Huntingdon Research Centre, Ltd. England. Study No. MBS 31/88999, May 3, 1989. MRID No. 42172801.
5. D.G. Barnes, and M.L. Dourson Reference dose (RfD): description and use in health risk assessments Reg. Toxicol. Pharm. 8 1988 471 486
6. G.S. Berkowitz, J.G. Wetmur, E. Birman-Deych, J. Obel, R.H. Lapinski, J.H. Godbold, I.R. Holzman, and M.S. Wolff In utero pesticide exposure, maternal paraoxonase activity, and head circumference Environ. Health Perspect. 112 3 2004 388 391
7. C.F. Brayton Dimethyl sulfoxide (DMSO): a review Cornell Vet. 76 1986 61 90
8. Breslin, W.J., Liberacki, A.B., Dittenber, D.A., Brzak, K.A., Quast, J.F., 1991. Chlorpyrifos: Two-generation dietary reproduction study in Sprague-Dawley rats. Unpublished report N0. K-044793-088 from the Toxicology Research Laboratory, Dow Chemical Co., Midland, Michigan, USA. Submitted to WHO by Dow AgroSciences, Indianapolis, Indiana, USA. MRID No. 41930301.
9. W.J. Breslin, A.B. Liberacki, D.A. Dittenber, and J.F. Quast Evaluation of the developmental and reproductive toxicity of chlorpyrifos in the rat Fundam. Appl. Toxicol. 29 1996 119 130
10. C.G. Campbell, F.J. Seidler, and T.A. Slotkin Chlorpyrifos interferes with cell development in rat brain regions Brain Res. Bull. 43 2 1997 179 189
11. G. Cavaletti, N. Oggioni, F. Sala, G. Pezzoni, E. Cavalletti, P. Marmiroli, M.G. Petruccioli, L. Frattola, and G. Tredici Effect on the peripheral nervous system of systemically administered dimethylsulfoxide in the rat: a neurophysiological and pathological study Toxicol. Lett. 118 2000 103 107
12. D. Clegg, and M. van Gemert Determination of the reference dose for chlorpyrifos: proceedings of an expert panel J. Toxicol. Environ. Health 2 1999 211 255
13. Coulston, F., Golberg, L., Griffin, T., 1972. Safety evaluation of Dowco 179 in human volunteers. Unpublished report from the Institute of Experimental Pathology and Toxicology, Albany Medical College. Albany, NY. MRID No. 00030754, 00095175.
14. K. Dam, F.J. Sedler, and T.A. Slotkin Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration Develop. Brain Res. 108 1998 39 45
15. M.M. Deacon, J.S. Murray, M.K. Pilny, K.S. Rao, D.A. Dittenber, T.R. Hanley, and J.A. John Embryotoxicity and fetotoxicity of orally administered chlorpyrifos in mice Toxicol. Appl. Pharmacol. 54 1980 31 40
16. M.L. Dourson Methods for establishing oral reference doses (RfDs) W. Mertz C.O. Abernathy S.S. Olin Risk Assessment of Essential Elements 1994 ILSI Press Washington, DC 51 61
17. J.A. Edwards, and S. Brimijoin Effects on hypophysectomy on acetylcholinesterase and butyrylcholinesterase in the rat Biochem. Pharmacol. 32 1983 1183 1189
18. B. Eskenazi, K. Harley, A. Bradman, E. Weltzien, N. Jewell, D. Barr, C. Furlong, and N. Holland Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population Environ. Health Perspect. 112 2004 1116 1124
19. P. Fenner-Crisp The FQPA 10x safety factor-How much is science? How much is sociology? HERA 7 1 2001 107 116
20. L.H. Fossom, R.B. Messing, and S.B. Sparber Long lasting behavioral effects of dimethyl sulfoxide and the "peripheral" toxicant p-bromophenylacetylurea Neurotoxicology 6 1985 17 28
21. L.T. Haber, J.S. Dollarhide, A. Maier, and M.L. Dourson Noncancer risk assessment: principles and practice in environmental and occupational settings E. Bingham B. Cohrssen C.H. Powell Patty's Toxicology fifth ed. 2001 Wiley New York, NY 169 232
22. Health Canada, 2003. Proposed acceptability for continuing registration: Phase 2 of the re-evaluation of chlorpyrifos. Ottawa, Canada. PACR2003-03.
23. IPCS (International Programme on Chemical Safety, 1999. Pesticide residues in food: Toxicological evaluation. http://www.inchem.org/documents/ jmpr/jmpmono/v99pr03.htm.
24. IPCS, 2001. Guidance document for the use of data in development of chemical-specific adjustment factors (CSAFs) for interspecies differences and human variability in dose/concentration-response assessment. WHO/PCS/01.4.
25. James, P., Stubbs, A., Parker, C.A., Offer, J.M., Anderson, A., 1988. The effect of Pyrinex (chlorpyrifos) on reproductive function of two generations in the rat. Unpublished report No. MBS 29/881452 from Huntingdon Research Centre, Ltd., Huntingdon, United Kingdom. Submitted to WHO by Makteshim Chemical Works, Beer-Sheva, Israel.
26. D.E. Johnson, F.J. Seidler, and T.A. Slotkin Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chlorpyrifos Brain Res. Bull. 45 2 1998 143 147
27. C.D. Klaassen Casarett & Doull's Toxicology: The Basic Science of Poisons sixth ed. 2001 McGraw-Hill New York, NY
28. Kisciki, J.C., Seip, C.W., Combs, M.L., 1999. A rising dose toxicology study to determine the no-observable-effect-levels (NOEL) for erythrocyte acetylcholinesterase (AchE) inhibition and cholinergic signs and symptoms of chlorpyrifos at three dose levels. Unpublished report from MDS Harris. MRID No. 44811002.
29. J. Liu, K. Olivier, and C.N. Pope Comparative neurochemical effects of repeated methyl parathion or chlorpyrifos exposures in neonatal and adult rats Toxicol. Appl. Pharmacol. 158 1999 186 196
30. J.L. Mattsson, P.J. Maurissen, R.J. Nolan, and K.A. Brzak Lack of differential sensitivity to cholinesterase inhibition in fetuses and neonates compared to dams treated perinatally with chlorpyrifos Toxicol. Sci. 53 2000 438 446
31. J.L. Mattsson, L. Holden, D.L. Eisenbrandt, and J.E. Gibson Reanalysis with optimized power of red blood cell acetylcholinesterase activity from a 1-year dietary treatment of dogs to chlorpyrifos Toxicology 160 2001 155 164
32. S.B. McCollister, R.J. Kociba, C.G. Humiston, D.D. McCollister, and P.J. Gehring Studies of the acute and long-term oral toxicity of chlorpyrifos (O,O-diethyl-O-3,5,6-trichloro-2-pyridyl phosphorothioate Food Cosmet. Toxicol. 12 1974 45 61
33. S.R. Mortensen, M.J. Hooper, and S. Padilla Rat brain acetylcholinesterase actvitiy: developmental profile and maturational sensitivity to carbamate and organophosphorus inhibitors Toxicology 125 1998 13 19
34. V.C. Moser, and S. Padilla Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats Toxicol. Appl. Pharmacol. 149 1998 107 119
35. R.J. Nolan, D.L. Rick, N.L. Freshour, and J.H. Saunders Chlorpyrifos, pharmacokinetics in human volunteers Toxicol. Appl. Pharmacol. 73 1984 8 15
36. A.C. Nordstrandt, S. Padilla, and V.C. Moser The relationship of oral chlorpyrifos effects on behavior, cholinesterase inhibition and muscarinic receptor density in rats Pharmacol. Biochem. Behav. 58 1997 15 23
37. C.N. Pope, T.K. Chakraborti, M.L. Chapman, J.D. Farrar, and D. Arthun Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides Toxicology 68 1991 51 61
38. D. Qiao, F.J. Seidler, S. Padilla, and T.A. Slotkin Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period? Environ. Health. Perspect. 110 11 2002 1097 1103
39. D. Qiao, F.J. Seidler, C.A. Tate, M.M. Cousins, and T.A. Slotkin Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood Environ. Health Perspect. 111 4 2003 536 544
40. D.B. Resnik, and C. Portier Pesticide testing on human subjects: weighing benefits and risks Environ. Health Perspect. 113 7 2005 813 817
41. J.R. Richardson, and J.E. Chambers Effects of gestational exposure to chlorpyrifos on postnatal central and peripheral cholinergic neurochemistry J. Toxicol. Environ. Health, Part A 66 2003 275 289
42. J.R. Richardson, and J.E. Chambers Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing rats Toxicol. Sci. 77 2004 83 90
43. Rubin, Y., Gal, N., Waner, T., Nyska, A., 1987a. Pyrinex. Teratogenicity study in the rat, Unpublished report No. MAK/101/PYR from Life Science Research Israel Ltd., Ness Ziona, Israel. Submitted to WHO by Makteshim Chemical Works, Beer-Sheva, Israel [cited in IPCS, 1999]. MRID No. 40436407.
44. Rubin, Y., Nyska, A., Waner, T., 1987b. Pyrinex teratogenicity study in the rabbit. Unpublished report No. MAK/103/PYR from Life Science Research Israel Ltd., Ness Ziona, Israel. Submitted to WHO by Makteshim Chemical Works, Beer-Sheva, Israel [cited in IPCS, 1999]. MRID No. 40436408.
45. G. Scarsella, G. Toschi, S.R. Bareggi, and E. Giacobini Molecular forms of cholinesterase in cerebrospinal fluid, blood plasma, and brain tissue of the beagle dog J. Neurosci. Res. 4 1979 19 24
46. X. Song, J.D. Violin, F.J. Seidler, and T.A. Slotkin Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells Toxicol. Appl. Pharmacol. 151 1998 182 191
47. C. Timchalk, A. Kousba, and T.S. Poet Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model Toxicol. Lett. 135 2002 51 59
48. UK ACP (Advisory Committee on Pesticides, 2003. Chlorpyrifos human health review: evaluation of further papers requested by the ACP, York, UK. ACP 6 (299/03).
49. US EPA (U.S. Environmental Protection Agency), 2000a. Human Health Risk Assessment: Chlorpyrifos. Health Effects Division, Office of Pesticide Programs, Washington, DC. June 8.
50. US EPA (U.S. Environmental Protection Agency), 2000b. Office of Pesticide Programs Science Policy on The Use of Data on Cholinesterase Inhibition for Risk Assessments of Organophosphorus and Carbamate Pesticides. Office of Pesticide Programs, Washington, DC. August 18.
51. USEPA (U.S. Environmental Protection Agency), 2002a. A Review of the Reference Dose and Reference Concentration Processes. Risk Assessment Forum, Washington, DC. May. EPA/630/P-02/002A.
52. US EPA (U.S. Environmental Protection Agency), 2002b. Determination of the appropriate FQPA safety factor(s) in tolerance assessment. Office of Pesticide Programs, Washington, DC. February, 28.
53. USEPA (U.S. Environmental Protection Agency, 2004. Integrated Risk Information System (IRIS. Glossary of Terms. Office of Research and Development, Washington, DC. Available online: http://www.epa.gov/iris.
54. M. van Gemert, M. Dourson, A. Moretto, and M. Watson Use of human data for the derivation of a reference dose for chlorpyrifos Reg. Toxicol. Pharmacol. 33 2001 110 116
55. D.D. Whitney, F.J. Seidler, and T.A. Slotkin Developmental neurotoxicity of chlorpyrifos: cellular mechanisms Toxicol. Appl. Pharmacol. 134 1995 53 62
56. WHO (World Health Organization), 2004. Chlorpyrifos in drinking-water: Background document for development of WHO Guidelines for Drinking-water Quality. World Health Organization, Geneva. WHO/SDE/WSH/03.04/87.
57. R.M. Whyatt, V. Rauh, D.B. Barr, D.E. Camann, H.F. Andrews, R. Garfinkel, L.A. Hoepner, D. Diaz, J. Dietrich, A. Reyes, D. Tang, P.L. Kinney, and F.P. Perera Prenatal insecticide exposures and birth weight and length among an urban minority cohort Environ. Health Perspect. 112 2004 1125 1132
58. B.L. Yano, J.T. Young, and J.L. Mattsson Lack of carcinogenicity of chlorpyrifos insecticide in a high-dose, 2-year dietary toxicity study in Fischer 344 rats Toxicol. Sci. 53 2000 135 144
59. Q. Zheng, K. Olivier, Y.K. Won, and C.N. Pope Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweaning and adult rats Toxicol. Sci. 55 2000 124 132
60. Q. Zhao, B. Gadagbui, and M. Dourson Lower birth weight as a critical effect of chlorpyrifos: a comparison of human and animal data Reg. Toxicol. Pharmacol. 42 1 2005 55 63