Regulation of K-Cl cotransport by protein phosphatase 1α in mouse erythrocytes

Pflugers Archiv European Journal of Physiology

Volumn 451, Issue 6, 2006, Pages 760-768

  De Franceschi, Lucia ^a   Villa Moruzzi, Emma ^b   Biondani, Andrea ^a   Siciliano, Angela ^a   Brugnara, Carlo ^c   Alper, Seth L ^d   Lowell, Clifford A ^e   Berton, Giorgio ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Membrane oxidative damage; Membrane transport; PP 1 ; Sickle cell disease; Src family kinases

Indexed keywords

CHLORINE; DITHIOTHREITOL; FGR PROTEIN; HEMATOPOIETIC CELL KINASE; ISOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 1ALPHA; POTASSIUM; PROTEIN TYROSINE KINASE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; ENZYME LOCALIZATION; ERYTHROCYTE; FEMALE; MALE; MEMBRANE TRANSPORT; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; REGULATORY MECHANISM; SICKLE CELL; STATISTICAL SIGNIFICANCE; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; CHLORIDES; ERYTHROCYTES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MICE; MICE, KNOCKOUT; POTASSIUM; PROTEIN ISOFORMS; PROTEIN PHOSPHATASE 1; PROTEIN SUBUNITS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-HCK; SRC-FAMILY KINASES; SYMPORTERS;

EID: 32444436470     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-005-1502-7     Document Type: Article

References (49)

1. Olivieri O, De Franceschi L, Capellini MD, Girelli D, Corrocher R, Brugnara C (1994) Oxidative damage and erythrocyte membrane transport abnormalities in thalassemias. Blood 84:315-320
2. Brugnara C, Bunn HF, Tosteson DC (1986) Regulation of erythrocyte cation and water content in sickle cell anemia. Science 232:388-390
3. Brugnara C, Bunn HF, Tosteson DC (1989) Ion content and transport and the regulation of volume in sickle cells. Ann NY Acad Sci 565:96-103
4. De Franceschi L, Villa-Moruzzi E, Fumagalli L, Brugnara C, Turrini F, Motta R et al (2001) K-Cl cotransport modulation by intracellular Mg in erythrocytes from mice bred for low and high Mg levels. Am J Physiol Cell Physiol 281:C1385-C1395
5. De Franceschi L, Saadane N, Trudel M, Alper SL, Brugnara C, Beuzard Y (1994) Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease. J Clin Invest 93:1670-1676
6. Brugnara C, De Franceschi L, Beuzard Y (2001) Erythrocyte-active agents and treatment of sickle cell disease. Semin Hematol 38:324-332
7. Joiner CH, Morris CL, Cooper ES (1993) Deoxygenation-induced cation fluxes in sickle cells. III. Cation selectivity and response to pH and membrane potential. Am J Physiol 264:C734-C744
8. Jennings ML, Schulz RK (1991) Okadaic acid inhibition of KCl cotransport. Evidence that protein dephosphorylation is necessary for activation of transport by either cell swelling or N-ethylmaleimide. J Gen Physiol 97:799-817
9. Jennings ML, Al-Rohil N (1990) Kinetics of activation and inactivation of swelling-stimulated K+/Cl- transport. The volume-sensitive parameter is the rate constant for inactivation. J Gen Physiol 95:1021-1040
10. Lauf PK, Bauer J, Adragna NC, Fujise H, Zade-Oppen AM, Ryu KH et al (1992) Erythrocyte K-Cl cotransport: properties and regulation. Am J Physiol 263:C917-C932
11. Lauf PK, Adragna NC (2000) K-Cl cotransport: properties and molecular mechanism. Cell Physiol Biochem 10:341-354
12. Lauf PK (1992) Incorporation of 3H- N-ethylmaleimide into sheep red cell membrane thiol groups following protection by diamide-induced oxidation. Mol Cell Biochem 114:13-20
13. Brugnara C, Van Ha T, Tosteson DC (1989) Role of chloride in potassium transport through a K-Cl cotransport system in human red blood cells. Am J Physiol 256:C994-C1003
14. Brugnara C, de Franceschi L (1993) Effect of cell age and phenylhydrazine on the cation transport properties of rabbit erythrocytes. J Cell Physiol 154:271-280
15. Dunham PB, Klimczak J, Logue PJ (1993) Swelling activation of K-Cl cotransport in LK sheep erythrocytes: a three-state process. J Gen Physiol 101:733-765
16. Fabry ME, Romero JR, Buchanan ID, Suzuka SM, Stamatoyannopoulos G, Nagel RL et al (1991) Rapid increase in red blood cell density driven by K:Cl cotransport in a subset of sickle cell anemia reticulocytes and discocytes. Blood 78:217-225
17. Canessa M, Spalvins A, Nagel RL (1986) Volume-dependent and NEM-stimulated K+,Cl- transport is elevated in oxygenated SS, SC and CC human red cells. FEBS Lett 200:197-202
18. Canessa M, Fabry ME, Blumenfeld N, Nagel RL (1987) Volume-stimulated, Cl(-)-dependent K+ efflux is highly expressed in young human red cells containing normal hemoglobin or HbS. J Membr Biol 97:97-105
19. Franco RS, Thompson H, Palascak M, Joiner CH (1997) The formation of transferrin receptor-positive sickle reticulocytes with intermediate density is not determined by fetal hemoglobin content. Blood 90:3195-3203
20. Franco RS, Palascak M, Thompson H, Joiner CH (1995) KCl cotransport activity in light versus dense transferrin receptor-positive sickle reticulocytes. J Clin Invest 95:2573-2580
21. Bize I, Munoz P, Canessa M, Dunham PB (1998) Stimulation of membrane serine-threonine phosphatase in erythrocytes by hydrogen peroxide and staurosporine. Am J Physiol 274:C440-C446
22. Bize I, Guvenc B, Robb A, Buchbinder G, Brugnara C (1999) Serine/threonine protein phosphatases and regulation of K-Cl cotransport in human erythrocytes. Am J Physiol 277:C926-C936
23. Bize I, Guvenc B, Buchbinder G, Brugnara C (2000) Stimulation of human erythrocyte K-Cl cotransport and protein phosphatase type 2A by n-ethylmaleimide: role of intracellular Mg++. J Membr Biol 177:159-168
24. Bize I, Taher S, Brugnara C (2003) Regulation of K-Cl cotransport during reticulocyte maturation and erythrocyte aging in normal and sickle erythrocytes. Am J Physiol Cell Physiol 285:C31-C38
25. Puntoni F, Villa-Moruzzi E (1997) Protein phosphatase-1 alpha, gamma 1, and delta: changes in phosphorylation and activity in mitotic HeLa cells and in cells released from the mitotic block. Arch Biochem Biophys 340:177-184
26. Tognarini M, Villa-Moruzzi E (1998) Analysis of the isoforms of protein phosphatase 1 (PP1) with polyclonal peptide antibodies. Methods Mol Biol 93:169-183
27. Hashikawa T, Nakazawa K, Mikawa S, Shima H, Nagao M (1995) Immunohistochemical localization of protein phosphatase isoforms in the rat cerebellum. Neurosci Res 22:133-136
28. Villa-Moruzzi E, Puntoni F (1996) Phosphorylation of phosphatase-1alpha in cells expressing v-src. Biochem Biophys Res Commun 219:863-867
29. Ouimet CC, da Cruz e Silva EF, Greengard P (1995) The alpha and gamma 1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines. Proc Natl Acad Sci USA 92:3396-3400
30. Shima H, Haneji T, Hatano Y, Kasugai I, Sugimura T, Nagao M (1993) Protein phosphatase 1 gamma 2 is associated with nuclei of meiotic cells in rat testis. Biochem Biophys Res Commun 194:930-937
31. Bollen M (2001) Combinatorial control of protein phosphatase-1. Trends Biochem Sci 26:426-431
32. Cohen P (1989) The structure and regulation of protein phosphatases. Annu Rev Biochem 58:453-508
33. De Franceschi L, Fumagalli L, Olivieri O, Corrocher R, Lowell CA, Berton G (1997) Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport. J Clin Invest 99:220-227
34. Merciris P, Hardy-Dessources MD, Giraud F (2001) Deoxygenation of sickle cells stimulates Syk tyrosine kinase and inhibits a membrane tyrosine phosphatase. Blood 98:3121-3127
35. Merciris P, Claussen WJ, Joiner CH, Giraud F (2003) Regulation of K-Cl cotransport by Syk and Src protein tyrosine kinases in deoxygenated sickle cells. Pflugers Arch 446:232-238
36. De Franceschi L, Beuzard Y, Brugnara C (1995) Sulfhydryl oxidation and activation of red cell K(+)-Cl- cotransport in the transgenic SAD mouse. Am J Physiol 269:C899-C906
37. Su W, Shmukler BE, Chernova MN, Stuart-Tilley AK, de Franceschi L, Brugnara C et al (1999) Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. Am J Physiol 277:C899-912
38. De Franceschi L, Beuzard Y, Jouault H, Brugnara C (1996) Modulation of erythrocyte potassium chloride cotransport, potassium content, and density by dietary magnesium intake in transgenic SAD mouse. Blood 88:2738-2744
39. De Franceschi L, Brugnara C, Rouyer-Fessard P, Jouault H, Beuzard Y (1999) Formation of dense erythrocytes in SAD mice exposed to chronic hypoxia: evaluation of different therapeutic regimens and of a combination of oral clotrimazole and magnesium therapies. Blood 94:4307-4313
40. Joiner CH (1993) Cation transport and volume regulation in sickle red blood cells. Am J Physiol 264:C251-C270
41. Armsby CC, Stuart-Tilley AK, Alper SL, Brugnara C (1996) Resistance to osmotic lysis in BXD-31 mouse erythrocytes: association with upregulated K-Cl cotransport. Am J Physiol 270:C866-C877
42. Brugnara C, Hipp MJ, Irving PJ, Lathrop H, Lee PA, Minchello EM et al (1994) Automated reticulocyte counting and measurement of reticulocyte cellular indices. Evaluation of the Miles H*3 blood analyzer. Am J Clin Pathol 102:623-632
43. Bain J, McLauchlan H, Elliott M, Cohen P (2003) The specificities of protein kinase inhibitors: an update. Biochem J 371:199-204
44. Bordin L, Brunati AM, Donella-Deana A, Baggio B, Toninello A, Clari G (2002) Band 3 is an anchor protein and a target for SHP-2 tyrosine phosphatase in human erythrocytes. Blood 100:276-282
45. Sasaki K, Shima H, Kitagawa Y, Irino S, Sugimura T, Nagao M (1990) Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas. Jpn J Cancer Res 81:1272-1280
46. Jennings ML (1999) Volume-sensitive K(+)/Cl(-) cotransport in rabbit erythrocytes. Analysis of the rate-limiting activation and inactivation events. J Gen Physiol 114:743-758
47. Sachs JR, Martin DW (1993) The role of ATP in swelling-stimulated K-Cl cotransport in human red cell ghosts. Phosphorylation-dephosphorylation events are not in the signal transduction pathway. J Gen Physiol 102:551-573
48. Hubbard MJ, Cohen P (1993) On target with a new mechanism for the regulation of protein phosphorylation. Trends Biochem Sci 18:172-177
49. Kim HS, Song MC, Kwak IH, Park TJ, Lim IK (2003) Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. J Biol Chem Sci 278:37497-37510