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Volumn 40, Issue 3, 2006, Pages 781-787
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Evaluation of recombinant human interferon α-2b structure and stability by in-gel tryptic digestion, H/D exchange and mass spectrometry
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Author keywords
2D gel electrophoresis; H D exchange; MALDI TOF MS; Methionine oxidation; Recombinant human interferon 2b; Stability
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Indexed keywords
DEUTERIUM;
METHIONINE;
POLYACRYLAMIDE GEL;
RECOMBINANT ALPHA2B INTERFERON;
TRYPSIN;
ARTICLE;
CIRCULAR DICHROISM;
DEUTERIUM HYDROGEN EXCHANGE;
DIMERIZATION;
DISULFIDE BOND;
DRUG OXIDATION;
DRUG STABILITY;
DRUG STRUCTURE;
LIQUID CHROMATOGRAPHY;
MACROMOLECULE;
MASS SPECTROMETRY;
MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY;
PRIORITY JOURNAL;
PROTEIN DEGRADATION;
PROTEIN INTERACTION;
PROTEIN STRUCTURE;
TWO DIMENSIONAL GEL ELECTROPHORESIS;
ULTRAVIOLET RADIATION;
AMINO ACID SEQUENCE;
CHROMATOGRAPHY, GEL;
CHROMATOGRAPHY, LIQUID;
CIRCULAR DICHROISM;
DRUG STABILITY;
GELS;
HUMANS;
HYDROLYSIS;
INTERFERON ALFA-2B;
KINETICS;
LINEAR MODELS;
MASS SPECTROMETRY;
MOLECULAR CONFORMATION;
MOLECULAR SEQUENCE DATA;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;
SPECTROPHOTOMETRY, ULTRAVIOLET;
TRYPSIN;
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EID: 32444434628
PISSN: 07317085
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jpba.2005.10.024 Document Type: Article |
Times cited : (18)
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References (27)
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