Assessment of a cellular vaccination approach consisting of Crawling Dendritic Cells (CDCs) transduced with HSV-1-Δpac vectors

Immunologic Research

Volumn 30, Issue 1, 2004, Pages 105-124

  Nuñez, Rafael ^a,b,c   Fraefel, Cornel ^a   Suter, Mark ^a   Nuñez Liman, Anne ^d   Liou, Hsiou Chi ^e   Ackerman, Mathias ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Amplicon HSV 1; CDC priming; Cellular vaccine; Dendritic cells; Infection; Transduction

Indexed keywords

ANTIBODY; BETA GALACTOSIDASE; GREEN FLUORESCENT PROTEIN; HERPESVIRUS VECTOR; VIRUS GLYCOPROTEIN;

AMPLICON; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CELL ACTIVITY; CELL BASED GENE THERAPY; CELL STIMULATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HUMORAL IMMUNITY; LYMPHOCYTE ACTIVATION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; TRANSGENE; VACCINATION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, VIRAL; CELLS, CULTURED; CYTOKINES; CYTOPATHOGENIC EFFECT, VIRAL; DENDRITIC CELLS; FLOW CYTOMETRY; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HERPESVIRUS 1, HUMAN; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES; TRANSGENES; VACCINATION;

EID: 3242891352     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:30:1:105     Document Type: Article

References (32)

1. Steinman RM: The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991;9:271-296.
2. Katz SI, Cooper KD, Iijima M, Tsuchida T: The role of Langerhans cells in antigen presentation. J Invest Dermatol 1985;85:96-98.
3. Cella M, Sallusto F, Lanzavecchia A: Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 1997;9:10-16.
4. Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature 1998;392:245-252.
5. Bender A, Sapp M, Schuler G, Steinman RM, Bhardwaj N: Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J Immunol Methods 1996;196:121-135.
6. Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, Steinman RM, Nussenzweig MC: The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen presentation. Nature 1995;375(6527):151-155.
7. Hock BD, Sterling GC, Daniel PB, Hart DN: Characterization of CMRF-44, a novel monoclonal antibody to an activation antigen expressed by allostimulatory cells within peripheral blood, including dendritic cells. Immunology 1994;83(4):573-581.
8. Sallusto F, Lanzavecchia A: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994;179:1109.
9. Geissmann F, Prost C, Monnet J-P, Dy M, Brousse N, Hermine O: Transforming Growth factor beta1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic langerhans cells. J Exp Med 1998;187:961-966.
10. Richters CD, Hoekstra MJ, van Baare J, Du Pont JS, Hoefsmit EC, Kamperdijk EW: Isolation and characterization of migratory human skin dendritic cells. Clin Exp Immunol 1994;98(2):330-336.
11. Steinman R, Hoffman L, Pope M: Maturation and migration of cutaneous dendritic cells. J Invest Dermatol 1995;105(1 Suppl):2S-7S.
12. Ortner U, Inaba K, Koch F, Heine M, Miwa M, Schuler G, Romani N: An improved isolation method for murine migratory cutaneous dendritic cells. J Immunol Methods 1996;193(1):71-79.
13. Nuñez R, Grob P, Baumann S, Zuniga A, Ackermann M, Suter M: Immortalized cell lines derived from mice lacking both type I and type II interferon receptors unify some functions of immature and mature dendritic cells. Immunol Cell Biol 1999;77:153-163.
14. Bouloc A, Walker P, Grivel JC, Vogel JC, Katz SI: Immunization through dermal delivery of protein-encoding DNA: a role for migratory dendritic cells. Eur J Immunol 1999;29(2):446-454.
15. Bot A, Stan AC, Inaba K, Steinman R, Bona C: Dendritic cells at a DNA vaccination site express the encoded influenza nucleoprotein and prime MHC class I-restricted cytolytic lymphocytes upon adoptive transfer. Int Immunol 2000;12(6):825-832.
16. Saeki H, Wu MT, Olasz E, Hwang ST: A migratory population of skin-derived dendritic cells expresses CXCR5, responds to B lymphocyte chemoattractant in vitro, and co-localizes to B cell zones in lymph nodes in vivo. Eur J Immunol 2000;30(10):2808-2814.
17. Perry LJ, McGeoch DJ: The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1. J Gen Virol 1988;69:2831-2846.
18. McGeoch DJ, Dalrymple MA, Davison AJ, Dolan A, Frame MC, McNab D, et al.: The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J Gen Virol 1988;69:1531-1574.
19. McGeoch DJ, Dalrymple MA, Dolan A, McNab D, Perry LJ, Taylor P, Challberg MD: Structures of herpes simplex virus type 1 genes required for replication of virus DNA. J Virol 1988;62:444-453.
20. Spaete RR, Frenkel N: The herpes simplex virus amplicon: a new eucaryotic defective-virus cloning-amplifying vector. Cell 1982;30:295-304.
21. Geller AI, Breakefield XO: A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons. Science 1988;241:1667-1669.
22. Fraefel C, Song S, Lim F, Lang P, Yu L, Wang Y, Wild P, Geller AI: Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells. J Virol 1996;70:7190-7197.
23. Fraefel C, Jacoby DR, Lage C, Hilderbrand H, Chou JY, Alt FW, et al.: Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors. Mol Med 1997;3:813-825.
24. Aboody-Guterman KS, Pechan PA, Rainov NG, Sena-Esteves M, Jacobs A, Snyder EY, et al.: Green fluorescent protein as a reporter for retrovirus and helper virus-free HSV-1 amplicon vector-mediated gene transfer into neural cells in culture and in vivo. Neuroreport 1997;8:3801-3808.
25. Wang X, Appukuttan B, Ott S, Patel R, Irvine J, Song J. et al.: Efficient and sustained transgene expression in human corneal cells mediated by a lentiviral vector. Gene Ther 2000;7:196-200.
26. Saeki Y, Ichikawa T, Saeki A, Chiocca EA, Tobler K, Ackermann M, et al.: Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors. Hum Gene Ther 1998;9:2787-2794.
27. Stavropoulos TA, Strathdee CA: An enhanced packaging system for helper-dependent herpes simplex virus vectors. J Virol 1998;72:7137-7143.
28. Saeki Y, Fraefel C, Ichikawa T, Breakefield XO, Chiocca EA: Improved helper virus-free packaging system for HSV amplicon vectors using an ICP27-deleted, over-sized HSV-1 DNA in a bacterial artificial chromosome. Mol Ther 2001;3(4):591-601.
29. Nuñez R, Ackermann M, Saeki Y, Ciocca A, Fraefel C: Flow cytometry assesment of transduction efficiency and cytotoxicity of Herpes Simplex Virus type 1 (HSV-1)-based amplicon vectors. Cytometry 2001;44:93-99.
30. Kamau S, Hurtado M, Müller-Doblies U, Grimm F, Nunez R: Flow Cytometric assessment of allopurinol susceptibility in Leishmania infantum promastigotes. Cytometry 2000;40:353-360.
31. Nuñez R: Assessment of surface markers and functionality of dendritic cells, in Current Protocols in Cytometry. Robinson JP, et al., eds. John Wiley & Sons, Inc., New York, 2001, pp. 9.17.1-9.17.15.
32. Suter M, Lew AM, Grob P, Adema GJ, Ackermann M, Shortman K, Fraefel C: BAC-VAC, a novel generation of (DNA) vaccines: a bacterial artificial chromosome (BAC) containing a replication-competent, packaging-defective virus genome induces protective immunity against herpes simplex virus 1. Proc Natl Acad Sci USA 1999;96:12697-12702.