Sympatho-modulatory therapies in perioperative medicine

British Journal of Anaesthesia

Volumn 93, Issue 1, 2004, Pages 53-62

  Zaugg, Michael ^a,b   Schulz, C ^a   Wacker, J ^a   Schaub, M C ^b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Agonists, alpha2 agonists; Anaesthetic techniques; Antagonists, beta adrenergic antagonists; Heart, perioperative cardioprotection; Receptors, adrenergic; Regional; Sympathetic nervous system

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANESTHETIC AGENT; ATENOLOL; ATROPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISOPROLOL; BUCINDOLOL; CARVEDILOL; CELIPROLOL; CLONIDINE; DEXMEDETOMIDINE; ESMOLOL; METOPROLOL; MIVAZEROL; MOXONIDINE; NEBIVOLOL; NORADRENALIN; PLACEBO; PROPRANOLOL;

ACUTE KIDNEY FAILURE; ADRENERGIC ACTIVITY; ANESTHESIOLOGY; BLOOD PRESSURE REGULATION; BRADYCARDIA; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; CLINICAL PRACTICE; CLINICAL TRIAL; CONGESTIVE CARDIOMYOPATHY; CORONARY ARTERY DISEASE; CORONARY ARTERY SURGERY; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; DRUG SELECTIVITY; DRUG SOLUBILITY; ELDERLY CARE; EPIDURAL ANESTHESIA; HEART ARREST; HEART INFARCTION; HUMAN; HYPOTENSION; LUNG DISEASE; PERIOPERATIVE PERIOD; PEROPERATIVE COMPLICATION; PRACTICE GUIDELINE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; REGIONAL ANESTHESIA; REVIEW; SPINAL ANESTHESIA; STROKE; SURGICAL TECHNIQUE; SYMPATHETIC TONE;

EID: 3242797425     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aeh158     Document Type: Article

References (85)

1. Amar D, Fleisher M, Oantuck CB, et al. Persistent alterations of the autonomic nervous system after noncardiac surgery. Anesthesiology 1998; 89: 30-42
2. Auerbach AD, Goldman L. Beta-blockers and reduction of cardiac events in norcardiac surgery. JAMA 2002; 287: 1435-47
3. Aybek T, Kessler P, Dogan S, et al. Awake coronary artery bypass grafting: utopia or reality? Ann Thorac Surg 2003; 75: 1165-70
4. Ballantyne J, Carr D, de Ferranti S, et al. The comparative effects of postoperative analgesic therapies on pulmonary outcome: cumulative meta-analysis of randomized, controlled trials. Anesth Analg 1998; 86: 598-612
5. Beattie W, Badner N, Choi P. Epidural analgesia reduces postoperative myocardial infarction: a meta-analysis. Anesth Analg 2001; 93: 853-8
6. BEST Trial Investigators. A trial of the beta-adrenergic blocker bucindolol in patients with advanced heart failure. N Engl J Med 2001; 344: 1659-67
7. Billinger M, Seiler C, Fleisch M, Eberli FR, Meier B, Hess OM. Do beta-adrenergic blocking agents increase coronary flow reserve? J Am Coll Cardiol 2001; 38: 1866-71
8. Blomberg S, Curelaru I, Emanuelsson H, Herlitz J, Ponten J, Ricksten SE. Thoracic epidural anaesthesia in patients with unstable angina pectoris. Eur Heart J 1989; 10: 437-44
9. Blomberg S, Emanuelsson H, Kvist H, et al. Effects of thoracic epidural anesthesia on coronary arteries and arterioles in patients with coronary artery disease. Anesthesiology 1990; 73: 840-7
10. Blomberg S, Ricksten SE. Effects of thoracic epidural anaesthesia on central haemodynamics compared to cardiac beta adrenoceptor blockade in conscious rats with acute myocardial infarction. Acta Anaesthesiol Scand 1990; 34: 1-17
11. Bonica JJ, Kennedy WF, Akamatsu TJ, et al. Circulatory effects of peridural block: III. Effects of acute blood loss. Anesthesiology 1972; 36: 219-27
12. Bristow MR. Antiadrenergic therapy of chronic heart failure. Surprises and new opportunities. Circulation 2003; 107: 1100-2
13. Bristow MR. Beta-adrenergic receptor blockade in chronic heart failure. Circulation 2000; 101: 558-69
14. Carpenter RL, Caplan RA, Brown DL, Stephenson C, Wu R. Incidence and risk factors for side effects of spinal anesthesia. Anesthesiology 1992; 76: 906-16
15. Chamberlain DP, Chamberlain BDL. Changes in skin temperature of the trunk and their relationship to sympathetic blockade during spinal anesthesia. Anesthesiology 1986; 65: 139-43
16. Cleophas TJ, Grabowsky I, Niemeyer MG, Mäkel WM, van der Wall EE, Nebivolol Follow-Up Study Group. Paradoxical pressor effects of beta-blockers in standing elderly patients with mild hypertension. A beneficial side effect. Circulation 2002; 105: 1669-71
17. Coats AJ. Heart failure 99; the MOXCON story. Int J Cardiol 1999; 71: 109-11
18. Dawood MM, Gutpa DK, Southern J, et al. Pathology of fatal perioperative myocardial infarction: implications regarding pathophysiology and prevention. Int J Cardiol 1996; 57: 37-44
19. Dobrydnjov I, Axelsson K, Samarütel J, Holmström B. Postoperative pain relief following intrathecal bupivacaine combined with intrathecal or oral clonidine. Acta Anesthesiol Scand 2002; 46: 806-14
20. Eagle KA, Berger PB, Calkins H, et al. ACC/AHA guideline update on perioperative cardiovascular evaluation for noncardiac surgery: a report of the ACC/AHA Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Circulation 2002; 105: 1257-67
21. Ebert TJ. Is gaining control of the autonomic nervous system important to our specialty? Anesthesiology 1999; 90: 651-53
22. Favarel-Garrigues JF, Sztark F, Petitjean ME, Thicoipe M, Lassie P, Dabadie P. Hemodynamic effects of spinal anesthesia in the elderly: single dose versus titration through catheter. Anesth Analg 1996; 82: 312-6
23. Fleisher LA, Eagle KA, Shaffer T, Anderson GF. Perioperative- and long-term mortality rates after major vascular surgery: the relationship to preoperative testing in the medicare population. Anesth Analg 1999; 89: 849-55
24. Fung JW, Chan SK, Yeung LY, Sanderson JE. Is beta-blockade useful in heart failure patients with atrial fibrillation? An analysis of data from two previously completed prospective trials. Eur J Heart Fail 2002; 4: 489-94
25. Gaffney TE, Braunwald EB. Importance of the adrenergic nervous system in the support of circulatory function in patients with congestive heart failure. Am J Med 1963; 34: 320-4
26. Gottlieb SS, Fisher ML, Kjekshus J, et al. Tolerability of beta-blocker initiation and titration in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF). Circulation 2002; 105: 1182-8
27. Gregorini L, Marco J, Farah B, et al. Effects of alpha1- and alpha2-adrenergic blockade on coronary flow reserve after coronary stenting. Circulation 2002; 106: 2901-9
28. Groeben H. Effects of high thoracic epidural anesthesia and local anesthetics on bronchial hyperreactivity. J Clin Monit Comp 2000; 16: 457-63
29. Hall JA, Kaumann AJ, Brown MJ. Selective α1-adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through β2-adrenoceptors in human atrial myocardium. Circ Res 1990; 66: 1610-23
30. Hayashi Y, Maze M. Drugs affecting adrenoceptors: alpha2-agonists. In: Bowdle TA, Horita A, Kharasch ED, eds. The Phormacologic Basis of Anaesthesiology. New York: Churchill Livingstone, 1994; 602-23
31. Jonkers RE, Koopmans RP, Portier EJ, van Boxtel CJ. Debrisoquine phenotype and the pharmacokinetics and beta-2 receptor pharmacodynamics of metoprolol and its enantiomers. J Pharmacol Exp Ther 1991; 256: 959-66
32. Kamibayashi T, Maze M. Clinical uses of alpha2-adrenergic agonists. Anesthesiology 2000; 93: 1345-9
33. Kertai MD, Bax JJ, Klein J, Poldermans D. Is there any reason to withhold β-blockers from high-risk patients with coronary artery disease during surgery? Anesthesiology 2004; 100: 4-7
34. Khan ZP, Ferguson CN, Jones RM. Alpha-2 and imidazoline receptor agonists. Anaesthesia 1999; 54: 146-65
35. Klassen G. The effect of acute sympathectomy by epidural anesthesia on the canine coronary circulation. Anesthesiology 1980; 52: 8-15
36. Kleinman B. Perioperative beta-blockade requires further study - not standard of care. APSF Newslett 2002; 17: 55
37. Lee TWR, Grocott HP, Schwinn D, Jacobsohn E, for the Winnipeg High-Spinal Anesthesia Group. High spinal anesthesia for cardiac surgery. Effects on beta-adrenergic receptor function, stress response, and hemodynamics. Anesthesiology 2003; 98: 499-510
38. Leopold G. Balanced pharmacokinetics and metabolism of bisoprolol. J Cardiovasc Pharmacol 1986; 8: S16-20
39. Lilja M, Jounela AJ, Justila H, Mattilla MJ. Interactions of clonidine and beta-blockers. Acta Med Scand 1980; 207: 173-6
40. Liu SS, McDonald SB. Current issues in spinal anesthesia. Anesthesiology 2001; 94: 888-906
41. Loick HM, Schmidt C, Van Aken H, et al. High thoracic epidural anesthesia, but not clonidine, attenuates the perioperative stress response via sympatholysis and reduces the release of troponin T in patients undergoing coronary artery bypass grafting. Anesth Analg 1999; 88: 701-9
42. London MJ, Zaugg M, Schaub MC, Spahn DR. Perioperative beta-blockade: physiological foundations and clinical controversies. Anesthesiology 2004; 100: 170-5
43. Mangano DT, Layug EL, Wallace A, Tateo I, for the Multicenter Study of Perioperative Ischemia Research Group. Effects of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. N Engl J Med 1996; 335: 1713-20
44. Mathias CJ, Wing LM, Frankel HL, Christensen NJ. Antihypertensive effects of clonidine in tetraplegic subjects devoid of central sympathetic control. Clin Sci 1979; 57: 425-8
45. McCallum JB, Boban N, Hogan Q, Schmeling WT, Kampine JP, Bosnjak ZJ. The mechanism of alpha2-adrenergic inhibition of sympathetic ganglionic transmission. Anesth Analg 1998; 87: 503-10
46. McSPI-EUROPE Research Group. Perioperative Sympatholysis. Beneficial effects of the alpha2-adrenoceptor agonist mivazerol on hemodynamic stability and myocardial ischemia. Anesthesiology 1997; 86: 346-63
47. Meissner A, Rolf N, Van Aken H. Thoracic epidural anesthesia and the patient with heart disease: benefits, risks, and controversies. Anesth Analg 1997; 85: 517-28
48. Morita K, Mori H, Tsujioka K, et al. Alpha-adrenergic vasoconstriction reduces systolic retrograde coronary blood flow. Am J Physiol 1997; 273: 21-12746-55
49. Nishikawa T, Dohi S. Oral clonidine blunts the heart rate response to intravenous atropine in humans. Anesthesiology 1991; 75: 217-22
50. Nishikawa T, Kimura T, Taguchi N, Dohi S. Oral clonidine preanesthetic medication augments the pressor response to intravenous ephedrine in awake or anesthetized patients. Anesthesiology 1991; 74: 705-10
51. Nishina K, Mikawa K, Uesugi T, et al. Efficacy of clonidine for prevention of perioperative myocardial ischemia. A critical appraisal and meta-analysis of the literature. Anesthesiology 2002; 96: 323-9
52. Norris EJ, Beattie C, Perler BA, et al. Double-masked randomized trial comparing alternate combinations of intraoperative anesthesia and postoperative analgesia in abdominal aortic surgery. Anesthesiology 2001; 95: 1054-67
53. O'Hara DA, Duff A, Berlin JA, et al. The effect of anesthetic technique on postoperative outcomes in hip fracture repair. Anesthesiology 2000; 92: 47-57
54. Oliver MF, Goldman L, Julian DG, Holme I. Effects of mivazerol on perioperative cardiac complications during non-cardiac surgery in patients with coronary heart disease: the European Mivazerol Trial (EMIT). Anesthesiology 1999; 91: 951-61
55. Paris A, Philipp M, Tonner PH, et al. Activation of α2B-adrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology 2003; 99: 889-95
56. Park WY Thompson JS, Lee KK. Effect of epidural anesthesia and analgesia on perioperative outcome: a randomized, controlled Veterans Affairs Cooperative Study. Ann Surg 2001; 234: 560-71
57. Parlow JL, Bégou G, Sagnard P, et al. Cardiac baroreflex during the postoperative period in patients with hypertension. Anesthesiology 1999; 90: 681-92
58. Peyton PJ, Myles PS, Silbert BS, et al. Perioperative epidural analgesia and outcome after major abdominal surgery in high risk patients. Anesth Analg 2003; 96: 548-54
59. Poldermans D, Boersma E, Bax JJ, et al. The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group. N Engl J Med 1999; 341: 1789-94
60. Pollard JB. Cardiac arrest during spinal anesthesia: common mechanisms and strategies for prevention. Anesth Analg 2001; 92: 252-6
61. Ponhold H, Vicenzi MN. Incidence of bradycardia during recovery from spinal anaesthesia: influence of patient position. Br J Anaesth 1998; 81: 7223-6
62. Priebe HJ. Perioperative beta-blocker therapy. Anesth Analg 2003; Review Course Lectures Supplement: 60-5
63. Raby KE, Brull SJ, Timimi F, et al. The effect of heart rate control on myocardial ischemia among high-risk patients after vascular surgery. Anesth Analg 1999; 88: 477-82
64. Reid JL, Wing LM, Mathias CJ, Frankel HL, Neill E. The central hypotensive effects of clonidine - studies in tetraplegic subjects. Clin Pharmacol Ther 1977; 21: 375-81
65. Rigg JRA, Jamrozik K, Myles PS, et al. Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial. Lancet 2002; 359: 1276-82
66. Rodgers A, Walker N, McKee A, et al. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. BMJ 2000; 321: 1-12
67. Saada M, Catoire P, Bonnet F, et al. Effect of thoracic epidural anesthesia combined with general anesthesia on segmental wall motion assessed by transesophageal echocardiography. Anesth Analg 1992; 75: 329-35
68. Saada M, Duval AM, Bonnet F, et al. Abnormalities in myocardial segmental wall motion during lumbar epidural anesthesia. Anesthesiology 1989; 71: 26-32
69. Sabbah HN, Stanley WC, Sharov VG, et al. Effects of dobutamine beta-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Circulation 2002; 102: 1990-5
70. Salpeter SR, Ormiston TM, Salpeter EE. Cardioselective beta-blockers in patients with reactive airway disease: a meta-analysis. Ann Intern Med 2002; 137: 715-25
71. Scott NB, Turfrey DJ, Ray DAA, et al. Prospective randomized study of the potential benefits of thoracic epidural anesthesia and analgesia in patients undergoing coronary artery bypass grafting. Anesth Analg 2001; 93: 528-35
72. Shyong EQ, Lucchinetti E, Tagliente TM, Hossain S, Silverstein JH, Zaugg M. Interleukin balance and early recovery from anesthesia in elderly surgical patients exposed to beta-adrenergic antagonism. J Clin Anesth 2003; 15: 170-8
73. Sivarajan M, Amory DM, Lindbloom LE. Systemic and regional blood flow during epidural anesthesia without epinephrine in the rhesus monkey. Anesthesiology 1976; 45: 300-10
74. Smiley RM, Kwatra MM, Schwinn DA. New developments in cardiovascular adrenergic receptor pharmacology: molecular mechanisms and clinical relevance. J Cardiothorac Vasc Anesth 1998; 12: 80-95
75. Soriano JB, Hoes AW, Meems L, Grobbee DE. Increased survival with β-blockers: importance of ancillary properties. Prog Cardiovasc Dis 1997; 39: 445-56
76. Stenseth R, Berg EM, Bjella L, Christensen O, Levang OW, Gisvold SE. The influence of thoracic epidural analgesia alone and in combination with general anesthesia on cardiovascular function and myocardial metabolism in patients receiving beta-adrenergic blockers. Anesth Analg 1993; 77: 463-8
77. Talke P, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT. The Study of Perioperative Ischemia Research Group. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. Anesthesiology 1995; 82: 620-33
78. Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE. Heterozygous alpha2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists. Proc Natl Acad Sci USA 2002; 99: 12471-6
79. Theodorou AE, Mistry H, Davies SL, Yamaguchi Y, Horton RW. Platelet alpha2-adrenoceptor binding and function during the menstrual cycle. J Psychiatr Res 1987; 21: 163-9
80. Urban MK, Markowitz SM, Gordon MA, Urquhart BL, Kligfield P. Postoperative prophylactic administration of beta-adrenergic blockers in patients at risk for myocardial ischemia. Anesth Analg 2000; 90: 1257-61
81. Urwin SC, Parker MJ, Griffiths R. General versus regional anaesthesia for hip fracture surgery: a meta-analysis of randomized trials. Br J Anaesth 2000; 84: 450-5
82. Wijeysundera DN, Naik JS, Beattie WS. Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: a meta-analysis. Am J Med 2003; 114: 742-4
83. Zaugg M, Schaub MC, Pasch T, Spahn DR. Modulation of β-adrenergic receptor subtype activities in perioperative medicine: mechanisms and sites of action. Br J Anaesth 2002; 88: 101-23
84. Zaugg M, Tagliente T, Lucchinetti E, et al. Beneficial effects from β-adrenergic blockade in elderly patients undergoing noncardiac surgery. Anesthesiology 1999; 91: 1674-86
85. Zaugg M, Tagliente T, Silverstein JH, Lucchinetti E. Atenolol may not modify anesthetic depth indicators in elderly patients - a second look at the data. Can J Anesth 2003; 50: 638-42