Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease

Biochemical and Biophysical Research Communications

Volumn 321, Issue 2, 2004, Pages 432-440

  Ohkura, Tsuyoshi ^a   Taniguchi, Shin Ichi ^a   Yamada, Kazuhiro ^b   Nishio, Naoko ^a   Okamura, Tomohisa ^a   Yoshida, Akio ^a   Kamijou, Keiichi ^c   Fukata, Shuji ^d   Kuma, Kanji ^d   Inoue, Yoichi ^e   Hisatome, Ichiro ^a   Senju, Satoru ^b   Nishimura, Yasuharu ^b   Shigemasa, Chiaki ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c Japan   (Japan)

^d KUMA HOSPITAL   (Japan)

^e Olympia Eye Hospital   (Japan)

Author keywords

Autoantigen; FRTL5; Graves' disease; Graves' ophthalmopathy; Ocular myopathy; Thyroid eye shared autoantigen; Uveal autoantigen with coiled coil domains and ankyrin repeats; Vogt Koyanagi Harada disease

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; UNCLASSIFIED DRUG; UVEAL AUTOANTIGEN WITH COILED COIL DOMAINS AND ANKYRIN REPEAT; UVEAL AUTOANTIGEN WITH COILED COIL DOMAINS AND ANKYRIN REPEATS ANTIBODY; IMMUNOGLOBULIN G; MESSENGER RNA; UACA ANTIGEN;

ADULT; ANIMAL CELL; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRAOCULAR MUSCLE; EYE DISEASE; FEMALE; GRAVES DISEASE; HASHIMOTO DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RAT; THYROID FOLLICLE CELL; THYROIDITIS; TISSUE DISTRIBUTION; BLOOD; CELL CULTURE; EYE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MUSCLE; PATHOLOGY; THYROID GLAND;

CANIS FAMILIARIS;

ADULT; AUTOANTIBODIES; AUTOANTIGENS; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE; FEMALE; GENE EXPRESSION REGULATION; GRAVES DISEASE; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; MUSCLES; RNA, MESSENGER; THYROID GLAND;

EID: 3242789426     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.06.162     Document Type: Article

References (31)

1. K. Yamada, S. Senju, T. Nakatsura, Y. Murata, M. Ishihara, S. Nakamura, S. Ohno, A. Negi and Y. Nishimura Identification of a novel autoantigen UACA in patients with panuveitis Biochem. Biophys. Res. Commun. 280 2001 1169 1176
2. F. Wilkin, V. Savonet, A. Radulescu, J. Petermans, J.E. Dumont and C. Maenhaut Identification and characterization of novel genes modulated in the thyroid of dogs treated with methimazole and propylthiouracil J. Biol. Chem. 271 1996 28451 28457
3. J. Kiljanski, V. Nebes and J.R. Wall The ocular muscle cell is a target of the immune system in endocrine ophthalmopathy Proc. Int. Arch. Allergy. Immunol. 106 1995 204 212
4. A.M. McGregor Has the autoantigen for Graves' ophthalmopathy been found? Lancet 352 1998 595 596
5. A.P. Weetman Thyroid-associated eye disease: pathophysiology Lancet 338 1991 28 35
6. J.R. Wall, M. Salvi, N. Bernard, A. Boucher and D. Haegert Thyroid-associated ophthalmopathy-A model for the association of organ-specific autoimmune disorder Immunol. Today 12 1991 150 153
7. H.B. Burch and L. Wartofsky Graves' ophthalmopathy: current concepts regarding pathogenesis and management Endocrinol. Rev. 14 1993 747 793
8. F. Karlsson, P. Dahlberg, P. Jansson, K. Westermark and P. Enoksson Importance of TSH receptor activation in the development of severe endocrine ophthalmopathy Acta Endocrinol. 121 1989 132 141
9. R.S. Bahn, C.M. Dutton, N. Natt, W. Joba, C. Spitzweg and E.A. Heufelder Thyrotropin receptor expression in Graves' orbital adipose/connective tissues: potential autoantigen in Graves' ophthalmopathy J. Clin. Endocrinol. Metab. 83 1998 998 1002
10. R. Paschke, A. Metcalfe, L. Alcalde, G. Vassart, A. Weetman and M. Ludgate Presence of nonfunctional thyrotropin receptor variant transcripts in retroocular and other tissues J. Clin. Endocrinol. Metab. 79 1994 1234 1238
11. R.S. Bahn Pathophysiology of Graves' ophthalmopathy: the cycle of disease J. Clin. Endocrinol. Metab. 88 2003 1939 1946
12. M. Salvi, A. Miller and J.R. Wall Human orbital tissue and thyroid membranes express a 64 kDa protein which is recognized by autoantibodies in the serum of patients with thyroid-associate ophthalmopathy FEBS Lett. 232 1988 135 139
13. Y. Hiromatsu, M. Sato, K. Tanaka, S. Shoji, K. Nonaka, M. Chinami and H. Fukazawa Significance of anti-eye muscle antibody in patients with thyroid-associated ophthalmopathy by quantitative Western blot Autoimmunity 14 1991 1 8
14. Y-J. Wu, S.E.M. Clarke and P. Shepherd Prevalence and significance of antibodies reactive with eye muscle membrane antigens in sera from patients with Graves' ophthalmopathy and other thyroid and nonthyroid disorders Thyroid 8 1998 167 174
15. S. Kubota, K. Gunji, C. Stolarski, J.S. Kennerdell and J.R. Wall Reevaluation of the prevalences of serum autoantibodies reactive with eye muscle antigens in patients with thyroid autoimmunity and ophthalmopathy Thyroid 8 1998 175 179
16. S. Kubota, K. Gunji, B.A.C. Ackrell, B. Cochran, C. Stolarski, S. Wengrowicz, J.S. Kennerdell, Y. Hiromatsu and J. Wall The 64-kDa eye muscle protein is the flavoprotein subunit of mitochondrial succinate dehydrogenase: the corresponding serum antibodies are good markers of an immune-medicated damage to the eye muscle in patients with Graves' hyperthyroidism J. Clin. Endocrinol. Metab. 83 1998 433 447
17. K. Gunji, A. De Bellis, S. Kubota, J. Swanson, S. Wengrowicz, B. Cochran, B.A. Ackrell, M. Salvi, A. Bellastella, A. Bizzarro, A.A. Sinisi and J.R. Wall Serum antibodies reactive against the flavoprotein subunit of succinate dehydrogenase are sensitive and specific markers of eye muscle autoimmunity in patients with Graves' hyperthyroidism J. Clin. Endocrinol. Metab. 84 1999 16 22
18. Q. Dong, M. Ludgate and G. Vassart Cloning and sequencing of a novel 64-kDa autoantigen recognized by patients with autoimmune thyroid disease J. Clin. Endocrinol. Metab. 72 1991 1375 1381
19. A. Barsouk, S. Wengrowicz, D. Scalise, C. Stolarski, V. Nebes, M. Sato and J.R. Wall New assays for the measurement of serum antibodies reactive with eye muscle membrane antigens confirm their significance in thyroid-associated ophthalmopathy Thyroid 5 1995 195 200
20. T.C. Chang, T.J. Chang, Y.S. Huang, K.M. Hua, R.J. Su and S.C.S. Kao Identification of autoantigen recognized by autoimmune ophthalmopathy sera with immunoblotting correlated with orbital computed tomography Clin. Immunol. Immunopathol. 65 1992 161 166
21. M. Salvi, N. Bernard, A. Miller, Z.G. Zhang, E. Gardini and J.R. Wal Prevalence of antibodies reactive with a 64 kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy Thyroid 1 1991 207 213
22. K. Gunji, A. De Bellis, A.W. Li, M. Yamada, S. Kubota, B. Ackrell, S. Wengrowicz, A. Bellastella, A. Bizzarro, A. Sinisi and J.R. Wall Cloning and characterization of the novel thyroid and eye muscle shared protein G2s: autoantibodies against G2s are closely associated with ophthalmopathy in patients with Graves' hyperthyroidism J. Clin. Endocrinol. Metab. 85 2000 1641 1647
23. M. Yamada, A.W. Li, K.A. West, C.H. Chang and J.R. Wall Experimental model for ophthalmopathy in BALB/c and outbred (CD-1) mice genetically immunized with G2s and the thyrotropin receptor Autoimmunity 35 2002 403 413
24. A. De Bellis, A. Bizzarro, M. Conte, C. Coronella, S. Solimeno, S. Perrino, D. Sansone, M. Guaglione, J.R. Wall and A. Bellastella Relationship between longitudinal behavior of some markers of eye autoimmunity and changes in ocular findings in patients with Graves' ophthalmopathy receiving corticosteroid therapy Clin. Endocrinol. (Oxf.). 59 2003 388 395
25. K.C. Ossoinig The role of standardized echography in Graves' disease Acta Ophthalmol. (Copenh) 204 1992 81
26. X.P. Pang, J.M. Hershman, M. Chung and A.E. Pekary Characterization of tumor necrosis factor-α receptors in human and rat thyroid cells and regulation of the receptors by thyrotropin Endocrinology 125 1989 1783 1788
27. T. Ito, T. Seyama, T. Hayashi, K. Dohi, T. Mizuno, K. Iwamoto, N. Tsuyama, N. Nakamura and M. Akiyama Establishment of two human thyroid carcinoma cell lines (8305C, 8505C) bearing p53 gene mutations Int. J. Oncol. 4 1994 583 586
28. M. Derwahl, M. Kuemmel, P. Goretzki, H. Schatz and M. Broecker Expression of the human TSH receptor in a human thyroid carcinoma cell line that lacks an endogenous TSH receptor Biochem. Biophys. Res. Commun. 191 1993 1131 1138
29. J.A. Fagin, K. Matsuo, A. Karmakar, D.L. Chen, S.H. Tang and H.P. Koeffler High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas J. Clin. Invest. 91 1993 179 184
30. T.P. Solovyeva Endocrine ophthalmopathies. Problems of rational classification Orbit 3 1989 193 198
31. S.E. Lux, K.M. John and V. Bennett Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins Nature 344 1990 36 42