Effects of levonorgestrel, medroxyprogesterone acetate, norethindrone, progesterone, and 17β-estradiol on thrombospondin-1 mRNA in Ishikawa cells

Fertility and Sterility

Volumn 82, Issue 1, 2004, Pages 220-222

  Mirkin, Sebastian ^a   Archer, David F ^a,b  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b The Jones Institute for Reproductive Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; ESTRADIOL; GESTAGEN; LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; MESSENGER RNA; NORETHISTERONE; PROGESTERONE; THROMBOSPONDIN 1;

ANGIOGENESIS; ARTICLE; CELL LINE; CELL TYPE; CONTRACEPTION; CONTROLLED STUDY; DISEASE MARKER; DRUG RESPONSE; ENDOMETRIAL DISEASE; HORMONE ACTION; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; UTERUS BLEEDING;

CELL LINE; CONTRACEPTIVE AGENTS, FEMALE; ENDOMETRIUM; EPITHELIAL CELLS; ESTRADIOL; FEMALE; HUMANS; PROGESTERONE; RNA, MESSENGER; THROMBOSPONDIN 1;

EID: 3242784131     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2004.02.100     Document Type: Article

References (21)

1. Glasier A. Implantable contraceptives for women effectiveness, discontinuation rates, return of fertility, and outcome of pregnancies. Contraception. 65:2002;29-37
2. d'Arcangues C. Management of vaginal bleeding irregularities induced by progestin-only contraceptives. Hum Reprod. 15:(Suppl 3):2000;24-29
3. Gargett C.E., Rogers P.A. Human endometrial angiogenesis. Reproduction. 121:2001;181-186
4. Hourihan M.A., Sheppard B.L., Brosen I.A. Endometrial hemostasis. d'Arcangues C., Fraser I.S., Newton J., Odlind V. Contraception and mechanisms of endometrial bleeding. 1990;95-114 Cambridge University Press, Cambridge
5. Laoag-Fernandez J.B., Maruo T., Pakarinen P., Spitz I.M., Johansson E. Effects of levonorgestrel-releasing intra-uterine system on the expression of vascular endothelial growth factor and adrenomedullin in the endometrium in adenomyosis. Hum Reprod. 18:2003;694-699
6. McGavigan C.J., Dockery P., Metaxa-Mariatou V., Campbell D., Stewart C.J., Cameron I.T., et al. Hormonally mediated disturbance of angiogenesis in the human endometrium after exposure to intrauterine levonorgestrel. Hum Reprod. 18:2003;77-84
7. Goodger A.M., Rogers P.A., Affandi B. Endometrial endothelial cell proliferation in long-term users of subdermal levonorgestrel. Hum Reprod. 9:1994;1647-1651
8. Rogers P.A., Au C.L., Affandi B. Endometrial microvascular density during the normal menstrual cycle and following exposure to long-term levonorgestrel. Hum Reprod. 8:1993;1396-1404
9. Hickey M., Fraser I.S. Surface vascularization and endometrial appearance in women with menorrhagia or using levonorgestrel contraceptive implants. Implications for the mechanisms of breakthrough bleeding. Hum Reprod. 17:2002;2428-2434
10. Archer DF, Leslie S, Navarro F, Mirkin S. Effects of levonorgestrel, medroxyprogesterone acetate, norethindrone and estradiol-17 beta on vascular epithelial growth factor isomers 121 and 165 in Ishikawa cells in vitro. Fertil Steril 2004;81:165-70
11. Smith S.K. Angiogenesis and reproduction. BJOG. 108:2001;777-783
12. DiPietro L.A., Nebgen D.R., Polverini P.J. Downregulation of endothelial cell thrombospondin-1 enhances in vitro angiogenesis. J Vasc Res. 31:1994;178-185
13. Lawler J. Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth. J Cell Mol Med. 6:2002;1-12
14. Iruela-Arispe ML, Porter P, Bornstein P, Sage EH. Thrombospondin-1, an inhibitor of angiogenesis, is regulated by progesterone in the human endometrium. Clin Invest 1996;97:403-12
15. Hague S., MacKenzie I.Z., Bicknell R., Rees M.C. In-vivo angiogenesis and progestogens. Hum Reprod. 17:2002;786-793
16. Ferenczy A. Pathophysiology of endometrial bleeding. Maturitas. 45:2003;1-14
17. Bein K., Simons M. Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity. J Biol Chem. 275:2000;32167-32173
18. Salamonsen L.A., Zhang J., Brasted M. Leukocyte networks and human endometrial remodelling. J Reprod Immunol. 57:2002;95-108
19. Salamonsen L.A., Zhang J., Hampton A., Lathbury L. Regulation of matrix metalloproteinases in human endometrium. Hum Reprod. 15:(Suppl 3):2000;112-119
20. Vincent A.J., Salamonsen L.A. The role of matrix metalloproteinases and leukocytes in abnormal uterine bleeding associated with progestin-only contraceptives. Hum Reprod. 15:(Suppl 3):2000;135-143
21. Vincent A.J., Zhang J., Ostor A., Rogers P.A., Affandi B., Kovacs G., et al. Matrix metalloproteinase-1 and -3 and mast cells are present in the endometrium of women using progestin-only contraceptives. Hum Reprod. 15:2000;123-130