Endocrine toxicology - Contributions of in vitro methods to the 3R concept

Altex

Volumn 21, Issue SUPPL. 3, 2004, Pages 20-27

  Freyberger, Alexius ^a   Scholz, Gabriele ^b  

^a BAYER PHARMA AG   (Germany)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Endocrine toxicology; In vitro methods; PALM cells; Sex hormone receptor binding assay; Transactivation assay

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; ALDOSTERONE; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANDROSTENEDIONE; CIMETIDINE; CORTICOSTERONE; CYPROTERONE ACETATE; CYTOSOL RECEPTOR; DETERGENT; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN; ESTRONE; FLUTAMIDE; HORMONE RECEPTOR; HYBRID PROTEIN; LINURON; LUCIFERASE; LUCIFERIN; METHOXYCHLOR; METRIBOLONE; PROCYMIDONE; PROGESTERONE; RECEPTOR PROTEIN; SEX HORMONE; TESTOSTERONE; THIOREDOXIN; UNINDEXED DRUG; VINCLOZOLIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CELL STRAIN; CORRELATION ANALYSIS; CYTOTOXICITY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENDOCRINE DISEASE; ESTROGEN ACTIVITY; HORMONE INHIBITION; HORMONE STRUCTURE; HUMAN; IN VITRO STUDY; METABOLIC CAPACITY; NONHUMAN; PREDICTION; RAT; RECEPTOR BINDING; RELIABILITY; STRUCTURE ANALYSIS; TRANSACTIVATION; VALIDATION PROCESS;

ANDROGEN ANTAGONISTS; ANIMAL TESTING ALTERNATIVES; ANIMALS; BIOLOGICAL ASSAY; CELL LINE; ENDOCRINE SYSTEM; GENES, REPORTER; HUMANS; PROTEIN BINDING; RECEPTORS, ANDROGEN; RECEPTORS, DRUG; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS;

EID: 3242781725     PISSN: 09467785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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