Differential effect of glyburide (glibenclamide) and metformin on qt dispersion: A potential adenosine triphosphate sensitive k+ channel effect

American Journal of Cardiology

Volumn 90, Issue 10, 2002, Pages 1103-1106

  Najeed, Syed A ^a   Khan, Ijaz A ^a   Molnar, Janos ^c   Somberg, John C ^b,d  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RUSH UNIVERSITY   (United States)

^c The Chicago Medical College   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLIBENCLAMIDE; HEMOGLOBIN A1C; METFORMIN; POTASSIUM CHANNEL;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET THERAPY; DRUG EFFECT; ELECTROCARDIOGRAPHY; GROUPS BY AGE; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL; RR INTERVAL;

ADMINISTRATION, ORAL; ADULT; AGED; ARRHYTHMIA; DIABETES MELLITUS, TYPE 2; ELECTROCARDIOGRAPHY; GLYBURIDE; HEART CONDUCTION SYSTEM; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; MALE; METFORMIN; MIDDLE AGED; TREATMENT OUTCOME;

EID: 0037111936     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(02)02776-5     Document Type: Article

References (20)

1. Meinert C.L., Knatterud G.L., Prout T.E., Klimt C.R. A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes II. Mortality results. Diabetes. 19:(suppl I):1970;789-830.
2. + channel in insulin secreting cells. Biochem Biophys Res Commun. 146:1987;21-25.
3. Ikeda T. QT prolongation in type 2 diabetes mellitus treated with glibenclamide. Diabetes Metab. 20:1994;565-567.
4. Schouten E.G., Dekker J.M., Meppelink P., Kok F.J., Vandenbroucke J.P., Pool J. QT interval prolongation predicts cardiovascular mortality in an apparently healthy population. Circulation. 84:1991;1516-1523.
5. Schwartz P.J., Wolf S. QT interval prolongation as predictor of sudden death in patients with myocardial infarction. Circulation. 57:1978;1074-1077.
6. Moss A.J. Measurement of the QT interval and the risk associated with QTc interval prolongation. Am J Cardiol. 72:1993;23B-25B.
7. Franz M.R., Bargheer K., Rafflenbeul W., Haverich A., Lichtlen P.R. Monophasic action potential mapping in human subjects with normal electrocardiograms: Direct evidence for the genesis of the T wave . Circulation. 75:1987;379-386.
8. Day C.P., McComb J.M., Campbell R.W. QT dispersion in sinus beats and ventricular extrasystoles in normal hearts. Br Heart J. 67:1992;39-41.
9. Pye M., Quinn A.C., Cobbe S.M. QT interval dispersion: A non-invasive marker of susceptibility to arrhythmia in patients with sustained ventricular arrhythmias? Br Heart J. 71:1994;511-514.
10. Barr C.S., Naas A., Freeman M., Lang C.C., Struthers A.D. QT dispersion and sudden unexpected death in chronic heart failure. Lancet. 343:1994;327-329.
11. Day C.P., McComb J.M., Campbell R.W. QT dispersion an indication of arrhythmia risk in patients with long QT intervals . Br Heart J. 63:1990;342-344.
12. Zareba W., Moss A.J., le Cessie S. Dispersion of ventricular repolarization and arrhythmic cardiac death in coronary artery disease. Am J Cardiol. 74:1994;550-553.
13. Higham P.D., Furniss S.S., Campbell R.W. QT dispersion and components of the QT interval in ischaemia and infarction. Br Heart J. 73:1995;32-36.
14. Glancy J.M., Garratt C.J., Woods K.L., de Bono D.P. QT dispersion and mortality after myocardial infarction. Lancet. 345:1995;945-948.
15. Ichkhan K., Molnar J., Somberg J. Relation of left ventricular mass and QT dispersion in patients with systematic hypertension. Am J Cardiol. 79:1997;508-511.
16. Buja G., Miorelli M., Turrini P., Melacini P., Nava A. Comparison of QT dispersion in hypertrophic cardiomyopathy between patients with and without ventricular arrhythmias and sudden death. Am J Cardiol. 72:1993;973-976.
17. Tun A., Khan I.A., Wattanasauwan N., Win M.T., Hussain A., Hla T.A., Cherukuri V.L., Vasavada B.C., Sacchi T.J. Increased regional and transmyocardial dispersion of ventricular repolarization in end-stage renal disease. Can J Cardiol. 15:1999;53-56.
18. Mirvis D.M. Spatial variation of QT intervals in normal persons and patients with acute myocardial infarction. J Am Coll Cardiol. 5:1985;625-631.
19. Gavrilescu S., Luca C. Right ventricular monophasic action potentials in patients with long QT syndrome. Br Heart J. 40:1978;1014-1018.
20. Pogatsa G., Koltai M.Z., Jermendy G., Simon J., Aranyi Z., Ballagi-Pordany G. The effect of sulphonylurea therapy on the outcome of coronary heart diseases in diabetic patients. Acta Med Hung. 49:1992-1993;39-51.