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Volumn 3, Issue 9, 2002, Pages 965-984

Mercury induces cytotoxicity and transcriptionally activates stress genesin human liver carcinoma (HepG2) cells

Author keywords

Cytotoxicity; Gene expression; Mercury

Indexed keywords

(4,5 DIMETHYLTHIAZOL 2YL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BROMINE DERIVATIVE; CHLORAMPHENICOL ACETYLTRANSFERASE; MERCURY; MERCURY CHLORIDE; PROTEIN; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

EID: 3242768443     PISSN: 14220067     EISSN: None     Source Type: Journal    
DOI: 10.3390/i3090965     Document Type: Article
Times cited : (43)

References (71)
  • 1
    • 3242767230 scopus 로고    scopus 로고
    • Agency For Toxic Substance and Disease Registry. U. S. Department of Health and Human Services. on line
    • ATSDR/EPA. Priority List for 1999; Top 20 Hazardous Substances, Agency For Toxic Substance and Disease Registry. U. S. Department of Health and Human Services. 1999, on line at: http://www.atsdr.cdc.gov/99/list.html.
    • (1999) Priority List for 1999; Top 20 Hazardous Substances
  • 2
    • 0003891569 scopus 로고
    • National Academy of Science Press, Washington, D.C.
    • NAS. An assessment of mercury in the environment. National Academy of Science Press, Washington, D.C., 1978.
    • (1978) An Assessment of Mercury in the Environment
  • 6
    • 85039486139 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency, Office of Air Quality Planning & Standards and Office of Research and Development. EPA-452/R-97-005. NTIS number: PB98-124753, 1997
    • U.S. EPA (1997a). Mercury study report to congress, volume III: Fate and transport of mercury in the environment. U.S. Environmental Protection Agency, Office of Air Quality Planning & Standards and Office of Research and Development. EPA-452/R-97-005. NTIS number: PB98-124753, 1997.
    • (1997) Mercury Study Report to Congress, Volume III: Fate and Transport of Mercury in the Environment , vol.3
  • 7
    • 0025458893 scopus 로고
    • New source identification of mercury contamination in the Great Lakes
    • Glass, G.E.; Sorensen, J.A.; Schmidt, K.W.; Rapp, G. R. New source identification of mercury contamination in the Great Lakes. Environ. Sci. Technol.. 1990, 24:1059-1069.
    • (1990) Environ. Sci. Technol. , vol.24 , pp. 1059-1069
    • Glass, G.E.1    Sorensen, J.A.2    Schmidt, K.W.3    Rapp, G.R.4
  • 9
    • 0003936978 scopus 로고
    • U.S. Department of Health, Education, and Welfare Public Health Service National Institutes of Health DHEW Publication No. (NIH) 74-473
    • Trakhtenberg, L.M. Chronic effects of mercury on organisms. U.S. Department of Health, Education, and Welfare Public Health Service National Institutes of Health DHEW Publication No. (NIH) 74-473, 1974.
    • (1974) Chronic Effects of Mercury on Organisms
    • Trakhtenberg, L.M.1
  • 10
    • 0019294691 scopus 로고
    • Histochemical changes in the neurosecretory hypothalic nuclei as a result of an intoxification with mercury compounds
    • Kozik, M.B.; Gramza, G. Histochemical changes in the neurosecretory hypothalic nuclei as a result of an intoxification with mercury compounds. Acta Histochem. Suppl. 1980, 22, 367-380.
    • (1980) Acta Histochem. Suppl. , vol.22 , pp. 367-380
    • Kozik, M.B.1    Gramza, G.2
  • 11
    • 20244375676 scopus 로고
    • Urinary mercury, porphyrins, and neurobehavioral changes of Dental workers in Monterrey, Mexico
    • Gonzalez-Ramirez, D. et al; Urinary mercury, porphyrins, and neurobehavioral changes of Dental workers in Monterrey, Mexico. J. Pharmocology and Experimental Therapeutics. 1995, 272(1), 264-274.
    • (1995) J. Pharmocology and Experimental Therapeutics , vol.272 , Issue.1 , pp. 264-274
    • Gonzalez-Ramirez, D.1
  • 12
    • 0027944855 scopus 로고
    • Metals and free radicals in neurodegeneration
    • Olanow, C.W.; Arendash, G.W. Metals and free radicals in neurodegeneration. Curr. Opin. Neurol. 1994, 7(6), 548-558.
    • (1994) Curr. Opin. Neurol. , vol.7 , Issue.6 , pp. 548-558
    • Olanow, C.W.1    Arendash, G.W.2
  • 13
    • 0033801568 scopus 로고    scopus 로고
    • The possible role of gradual accumulation of copper, cadmium, lead, and iron depletion of zinc, magnesium, selenium, vitamins B2, B6, D, and E and essential fatty acids in multiple sclerosis
    • Johnson, S. The possible role of gradual accumulation of copper, cadmium, lead, and iron depletion of zinc, magnesium, selenium, vitamins B2, B6, D, and E and essential fatty acids in multiple sclerosis. Med Hypotheses. 2000, 55(3), 239-241.
    • (2000) Med. Hypotheses , vol.55 , Issue.3 , pp. 239-241
    • Johnson, S.1
  • 15
    • 0029166257 scopus 로고
    • Effects of SH-blocking compounds on the energy metabolism in isolated rat hepatocytes
    • Boot, J.H. Effects of SH-blocking compounds on the energy metabolism in isolated rat hepatocytes. Cell. Struct. Funct. 1995, 20(3), 233-238.
    • (1995) Cell. Struct. Funct. , vol.20 , Issue.3 , pp. 233-238
    • Boot, J.H.1
  • 16
    • 0025866988 scopus 로고
    • Toxic heavy metal ions inhibit reduction of disulfide bonds
    • Matts, R.L.; Schatz, J.R.; Hurst, R.; Kagen, R. Toxic heavy metal ions inhibit reduction of disulfide bonds. J. Biol Chem. 1991, 266(19), 12695-12703.
    • (1991) J. Biol. Chem. , vol.266 , Issue.19 , pp. 12695-12703
    • Matts, R.L.1    Schatz, J.R.2    Hurst, R.3    Kagen, R.4
  • 17
    • 3242760212 scopus 로고
    • Teratogenic and genetic effects of mercury toxicity
    • Khera et al. Teratogenic and genetic effects of mercury toxicity. Teratology. 1990, 8, 293-304.
    • (1990) Teratology , vol.8 , pp. 293-304
    • Khera1
  • 18
    • 0027183546 scopus 로고
    • Transition metals in control of gene expression
    • O'Halloran, T.V. Transition metals in control of gene expression. Science 1993, 261(5122), 715-725.
    • (1993) Science , vol.261 , Issue.5122 , pp. 715-725
    • O'Halloran, T.V.1
  • 19
    • 0028948037 scopus 로고
    • Nutrition and metal toxicity
    • Goyer, R.A. Nutrition and metal toxicity. Am. J. Clin. Nutr. 1995, 61(suppl 3), 545S-650S.
    • (1995) Am. J. Clin. Nutr. , vol.61 , Issue.SUPPL. 3
    • Goyer, R.A.1
  • 20
    • 0029655257 scopus 로고    scopus 로고
    • Autoimmune disease induced by mercuric chloride
    • Kubicka et al. Autoimmune disease induced by mercuric chloride. Int Arch Allergy Immunol. 1996, 109(1), 11-20.
    • (1996) Int. Arch. Allergy Immunol. , vol.109 , Issue.1 , pp. 11-20
    • Kubicka1
  • 21
    • 0030018709 scopus 로고    scopus 로고
    • Xenobiotic metabolism and adverse environmental response: Sulfur dependent detoxification pathways
    • McFadden, S.A. Xenobiotic metabolism and adverse environmental response: sulfur dependent detoxification pathways. Toxicology. 1996, 111(1-3), 43-65.
    • (1996) Toxicology , vol.111 , Issue.1-3 , pp. 43-65
    • McFadden, S.A.1
  • 22
    • 0014845875 scopus 로고
    • Studies on the metabolism of vitamin B6 in the small intestine. Purification and properties of monkey intestinal pyridoxal kinases
    • Srikantarah, M.V.; Radjakushnan, A. N. Studies on the metabolism of vitamin B6 in the small intestine. Purification and properties of monkey intestinal pyridoxal kinases. Indian J. Biochem. 1970, 7(3), 151-156.
    • (1970) Indian J. Biochem. , vol.7 , Issue.3 , pp. 151-156
    • Srikantarah, M.V.1    Radjakushnan, A.N.2
  • 23
    • 0022908021 scopus 로고
    • Alterations of heme cytochrome P-450, and steroid metabolism by mercury in rat adrenal gland
    • Veltman, J.C. Alterations of heme cytochrome P-450, and steroid metabolism by mercury in rat adrenal gland. Arch Biochem Biophys. 1986, 248(2), 467-478.
    • (1986) Arch. Biochem. Biophys. , vol.248 , Issue.2 , pp. 467-478
    • Veltman, J.C.1
  • 24
    • 3242746312 scopus 로고
    • Ferotoxicity of inorganic mercury: Distribution and effect of nutrient uptake by placenta and fetus
    • Danielson, B.R. Ferotoxicity of inorganic mercury: Distribution and effect of nutrient uptake by placenta and fetus. Neurotoxicol. Teratol. 1984, 18, 129-134.
    • (1984) Neurotoxicol. Teratol. , vol.18 , pp. 129-134
    • Danielson, B.R.1
  • 25
    • 0029655257 scopus 로고    scopus 로고
    • Systemic autoimmune disease induced by mercuric chloride
    • Kubicka-Murranyi, M. "Systemic autoimmune disease induced by mercuric chloride. Int Arch Allergy Immunol. 1996, 109(1), 11-20.
    • (1996) Int. Arch. Allergy Immunol. , vol.109 , Issue.1 , pp. 11-20
    • Kubicka-Murranyi, M.1
  • 26
    • 85039490657 scopus 로고    scopus 로고
    • U. S. Environmental Protection Agency, Office of Air Quality Planning and Standards and Office of Research and Development. EPA-452/R-97-005. NTIS number: PB98-12444753
    • U. S. EPA. Mercury study report to congress. Volume V: Health effects of mercury and mercury compounds. U. S. Environmental Protection Agency, Office of Air Quality Planning and Standards and Office of Research and Development. EPA-452/R-97-005. NTIS number: PB98-12444753, 1997.
    • (1997) Mercury Study Report to Congress. Volume V: Health Effects of Mercury and Mercury Compounds , vol.5
  • 27
    • 3242807758 scopus 로고
    • Geneva, Switzerland: World Health Organization
    • WHO. Inorganic mercury volume 118. Geneva, Switzerland: World Health Organization, 1991.
    • (1991) Inorganic Mercury Volume 118 , vol.118
  • 29
    • 0342576933 scopus 로고
    • Clinical and neurochemical aspects of inorganic mercury intoxification
    • Elsevier, Amsterdam
    • Kaik, P. Clinical and neurochemical aspects of inorganic mercury intoxification. In handbook of clinical neurology, Elsevier, Amsterdam, 36, 147-197, 1979.
    • (1979) Handbook of Clinical Neurology , vol.36 , pp. 147-197
    • Kaik, P.1
  • 30
    • 0001103592 scopus 로고
    • The epidemiology of mercury poisoning
    • Nriagu, J.O. eds Elsevier, Amsterdam
    • Takizawa, Y. The epidemiology of mercury poisoning. In the biogeochemistry of mercury in the environment, Nriagu, J.O. eds Elsevier, Amsterdam pp. 325-366, 1979.
    • (1979) The Biogeochemistry of Mercury in the Environment , pp. 325-366
    • Takizawa, Y.1
  • 31
    • 77957181404 scopus 로고
    • The CAT-Tox (L) assay: A sensitive and specific measure of stress induced transcription in transformed liver cells
    • Todd, M.D.; Lee, M.J.; Williams, J.L.; Nalenzy, J.M.; Gee, P.; Benjamin, M.B.; Farr, S.B. The CAT-Tox (L) assay: A sensitive and specific measure of stress induced transcription in transformed liver cells. Fundam. Appl. Toxicol. 1995, 28, 118-128.
    • (1995) Fundam. Appl. Toxicol. , vol.28 , pp. 118-128
    • Todd, M.D.1    Lee, M.J.2    Williams, J.L.3    Nalenzy, J.M.4    Gee, P.5    Benjamin, M.B.6    Farr, S.B.7
  • 32
    • 0002979341 scopus 로고    scopus 로고
    • Cytogenic assessment of arsenic trioxide toxicity in the Mutatox, Ames II and CAT-Tox assays
    • Tchounwou, P.B.; Wilson, B.A.; Schneider, J.; Ishaque, A. Cytogenic assessment of arsenic trioxide toxicity in the Mutatox, Ames II and CAT-Tox assays. Metal Ions Biol. Med. 2000, 6, 89-91.
    • (2000) Metal Ions Biol. Med. , vol.6 , pp. 89-91
    • Tchounwou, P.B.1    Wilson, B.A.2    Schneider, J.3    Ishaque, A.4
  • 33
    • 77957181404 scopus 로고
    • The CAT-Tox (L) assay: A sensitive and specific measure of stress induced transcription in transformed liver cells
    • Todd, M.D.; Lee, M.J.; Williams, J.L.; Nalenzy, J.M.; Gee, P.; Benjamin, M.B.; Farr, S.B. The CAT-Tox (L) assay: A sensitive and specific measure of stress induced transcription in transformed liver cells. Fundam. Appl. Toxicol. 1995, 28, 118-128.
    • (1995) Fundam. Appl. Toxicol. , vol.28 , pp. 118-128
    • Todd, M.D.1    Lee, M.J.2    Williams, J.L.3    Nalenzy, J.M.4    Gee, P.5    Benjamin, M.B.6    Farr, S.B.7
  • 34
    • 0002191589 scopus 로고    scopus 로고
    • Health risk assessment and management of arsenic and other hazardous metals in drinking water
    • Tchounwou, P.B. Health risk assessment and management of arsenic and other hazardous metals in drinking water. Metal Ions Biol. Med. 2000, 6, 21-23.
    • (2000) Metal Ions Biol. Med. , vol.6 , pp. 21-23
    • Tchounwou, P.B.1
  • 38
    • 0033957486 scopus 로고    scopus 로고
    • Mercury induces cell cytotoxicity and oxidative stress and increases β-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells
    • Olivieri, G.; Brack, C.; Muller-Spahn, F.; Stahelin, H.B.; Herrmann, M.; Renard, P.; Brockhaus, M.; Hock, C. Mercury induces cell cytotoxicity and oxidative stress and increases β-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells. Journal of Neurochemistry. 2000, 74, 231-236.
    • (2000) Journal of Neurochemistry , vol.74 , pp. 231-236
    • Olivieri, G.1    Brack, C.2    Muller-Spahn, F.3    Stahelin, H.B.4    Herrmann, M.5    Renard, P.6    Brockhaus, M.7    Hock, C.8
  • 39
    • 0033791432 scopus 로고    scopus 로고
    • Mercury induced apoptosis in human Lymphoid cells: Evidence that the apoptotic pathway is mercurial species dependent
    • Shenker, B.J.; Guo, T.L.; Shapiro, I.M. Mercury induced apoptosis in human Lymphoid cells: Evidence that the apoptotic pathway is mercurial species dependent. Environmental Research. 2000, 84, 89-99.
    • (2000) Environmental Research , vol.84 , pp. 89-99
    • Shenker, B.J.1    Guo, T.L.2    Shapiro, I.M.3
  • 41
    • 84856132103 scopus 로고
    • Mercury
    • Frieberg, G.R.; Norber, V.B.; Vouk, B. ed. New York:Elsevier Press
    • nd edition, Frieberg, G.R.; Norber, V.B.; Vouk, B. ed. New York:Elsevier Press. 1980.
    • (1980) nd Edition
    • Berlin, M.1
  • 45
    • 0027300033 scopus 로고
    • Glutathione S-transferases: Structure, regulation, and therapeutic implications
    • Rushmore, T.H.; Pickett, C.B. Glutathione S-transferases: structure, regulation, and therapeutic implications. J. Biol. Chem.. 1993, 268, 11475-11478.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11475-11478
    • Rushmore, T.H.1    Pickett, C.B.2
  • 46
    • 0025368036 scopus 로고
    • Regulation of glutathione S-transferase Ya subunit gene expression: Identification of a unique xenobiotic responsive element controlling inducible expression by planar aromatic compounds
    • Rushmore, T.H.; King, R.G.; Paulson, K.E.; Pickett, C.B. Regulation of glutathione S-transferase Ya subunit gene expression: Identification of a unique xenobiotic responsive element controlling inducible expression by planar aromatic compounds. Proc. Natl. Acad. Sci.. 1990, 87, 3826-3830.
    • (1990) Proc. Natl. Acad. Sci. , vol.87 , pp. 3826-3830
    • Rushmore, T.H.1    King, R.G.2    Paulson, K.E.3    Pickett, C.B.4
  • 47
    • 85173833953 scopus 로고    scopus 로고
    • Interactions between glutathione and mercury in the kidney, liver and blood
    • Chang, L.W., ed. Boca Raton: CRC Press
    • Zalups, R.K.; Lash, L.H. Interactions between glutathione and mercury in the kidney, liver and blood. In: Chang, L.W., ed. Toxicology of Metals. Boca Raton: CRC Press; 1996:145-163.
    • (1996) Toxicology of Metals , pp. 145-163
    • Zalups, R.K.1    Lash, L.H.2
  • 48
    • 0022555879 scopus 로고
    • Metallothionein
    • Hamer, D.H. Metallothionein. Ann. Rev. Biochem.. 1986, 55, 913-951.
    • (1986) Ann. Rev. Biochem. , vol.55 , pp. 913-951
    • Hamer, D.H.1
  • 49
    • 0023072503 scopus 로고
    • Analysis of detoxification of heavy metal ions by mouse metallothionein
    • Burman, D.M.; Palmiter, R.D. Analysis of detoxification of heavy metal ions by mouse metallothionein. EXS.. 1987, 52, 457-463.
    • (1987) EXS. , vol.52 , pp. 457-463
    • Burman, D.M.1    Palmiter, R.D.2
  • 50
    • 0031966275 scopus 로고    scopus 로고
    • Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury
    • Klassen, C.D.; Liu, J. Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury. Environ. Health Perspect.. 1998, 106, 297-300.
    • (1998) Environ. Health Perspect. , vol.106 , pp. 297-300
    • Klassen, C.D.1    Liu, J.2
  • 51
    • 0027202273 scopus 로고
    • The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by hsp70
    • Mosser, D.D.; Duchanie, J.; Massie, B. The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by hsp70. Mol. Cell. Biol.. 1993, 13, 5427-5438.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 5427-5438
    • Mosser, D.D.1    Duchanie, J.2    Massie, B.3
  • 52
    • 0023815651 scopus 로고
    • Coordinate changes in heat shock element binding activity and HSP70 gene transcription rates in human cells
    • Mosser, D.D.; Theodorakis, N.G.; Morimoto, R.I. Coordinate changes in heat shock element binding activity and HSP70 gene transcription rates in human cells. Mol. Cell. Biol.. 1988, 8, 3733-3736.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 3733-3736
    • Mosser, D.D.1    Theodorakis, N.G.2    Morimoto, R.I.3
  • 53
    • 0026773208 scopus 로고
    • Protein folding in the cell: The role of molecular chaperones HSP70 and HSP60
    • Hartl, F.U.; Martin, J.; Neupert, W. protein folding in the cell: The role of molecular chaperones HSP70 and HSP60. Annu. Rev. Biophys. Biomol. Struct.. 1992, 21, 293-322.
    • (1992) Annu. Rev. Biophys. Biomol. Struct. , vol.21 , pp. 293-322
    • Hartl, F.U.1    Martin, J.2    Neupert, W.3
  • 54
    • 0031939228 scopus 로고    scopus 로고
    • HSP72 mRNA production in cultured human cells submitted to non-lethal aggression by heat, ethanol, or propanol. Application to the detection of low concentration of chromium (VI) (potassium dichromate)
    • Delmas, R.; Schaak, S.; Gaubin, Y.; Croute, F.; Arrabit, C.; Murat, J. C. HSP72 mRNA production in cultured human cells submitted to non-lethal aggression by heat, ethanol, or propanol. Application to the detection of low concentration of chromium (VI) (potassium dichromate). Cell. Biol. Toxicol.. 1998, 14, 39-46.
    • (1998) Cell. Biol. Toxicol. , vol.14 , pp. 39-46
    • Delmas, R.1    Schaak, S.2    Gaubin, Y.3    Croute, F.4    Arrabit, C.5    Murat, J.C.6
  • 55
    • 0024446685 scopus 로고
    • 2 and methyl mercury in astrocytes: Selectivity and reversibility
    • 2 and methyl mercury in astrocytes: selectivity and reversibility. Journal of Neurochemistry. 1989, 53(4), 1228-1237.
    • (1989) Journal of Neurochemistry , vol.53 , Issue.4 , pp. 1228-1237
    • Brookes, N.1    Kristt, D.A.2
  • 56
    • 0026076021 scopus 로고
    • Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif, which interacts with CTF/NF-1
    • Wooden, S.K.; Li, L.J.; Navarro, D.; Qadri, I.; Pereira, L.; Lee, A.S. Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif, which interacts with CTF/NF-1. Mol. Cell. Biol.. 1991, 11, 5612-5623.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 5612-5623
    • Wooden, S.K.1    Li, L.J.2    Navarro, D.3    Qadri, I.4    Pereira, L.5    Lee, A.S.6
  • 57
    • 0023813266 scopus 로고
    • Activation of the c-fos gene by UV and phorbol ester: Different signal pathways converge to the same enhancer element
    • Buscher, M.; Rahmsdorf, M; Litfin, M.; Herrlich, P. Activation of the c-fos gene by UV and phorbol ester: different signal pathways converge to the same enhancer element. Oncogene. 1988, 3, 301-311.
    • (1988) Oncogene , vol.3 , pp. 301-311
    • Buscher, M.1    Rahmsdorf, M.2    Litfin, M.3    Herrlich, P.4
  • 58
    • 0023989346 scopus 로고
    • The c-fos serum response element responds to protein kinase c-dependent and independent signals but not to cyclic AMP
    • Gilman, M.Z. The c-fos serum response element responds to protein kinase c-dependent and independent signals but not to cyclic AMP. Genes Dev.. 1988, 2, 394-399.
    • (1988) Genes Dev. , vol.2 , pp. 394-399
    • Gilman, M.Z.1
  • 59
    • 0024431797 scopus 로고
    • Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter
    • Berkowitz, L.A.; Riabowal, K.T.; Gilman, M.Z. Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter. Mol. Cell. Biol.. 1989, 9, 4722-4731.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 4722-4731
    • Berkowitz, L.A.1    Riabowal, K.T.2    Gilman, M.Z.3
  • 60
    • 0024225850 scopus 로고
    • Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: Characterization of cAMP response element
    • Sassosne-Corsi, P; Visvander, J.; Ferland, L; Mellon, P.; Verma, L.N. Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of cAMP response element. Genes Dev.. 1988, 2, 1529-1538.
    • (1988) Genes Dev. , vol.2 , pp. 1529-1538
    • Sassosne-Corsi, P.1    Visvander, J.2    Ferland, L.3    Mellon, P.4    Verma, L.N.5
  • 61
    • 0027215902 scopus 로고
    • Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathway
    • Bading, H.; Ginty, D.D.; Greenbert, M.E. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathway. Science, 1993, 260, 181-186.
    • (1993) Science , vol.260 , pp. 181-186
    • Bading, H.1    Ginty, D.D.2    Greenbert, M.E.3
  • 62
    • 0028338460 scopus 로고
    • Nerve growth factor activates a Ras dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB
    • Ginty, D.D.; Bonni, A.; Greenberg, M.E. Nerve growth factor activates a Ras dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell. 1994, 77, 713-725.
    • (1994) Cell , vol.77 , pp. 713-725
    • Ginty, D.D.1    Bonni, A.2    Greenberg, M.E.3
  • 63
    • 0023034795 scopus 로고
    • Stimulation of neuronal acetylcholine receptors induce rapid gene transcription
    • Greenberg, M.E.; Ziff, E.B.; Green, L.A. Stimulation of neuronal acetylcholine receptors induce rapid gene transcription. Science. 1986, 234, 80-83.
    • (1986) Science , vol.234 , pp. 80-83
    • Greenberg, M.E.1    Ziff, E.B.2    Green, L.A.3
  • 64
    • 0025720735 scopus 로고
    • The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation
    • Angel, P. Karin, M. The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochem. Biophys. Acta. 1991, 1072, 129-157.
    • (1991) Biochem. Biophys. Acta , vol.1072 , pp. 129-157
    • Angel, P.1    Karin, M.2
  • 68
    • 0026760343 scopus 로고
    • Calcium ionophore A23178 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153
    • Bartlett, J.D.; Leuthy, J.D.; Carlson, S.G.; Sollott, S.J.; Holbrook, N.J. Calcium ionophore A23178 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153. J. Biol. Chem.. 1992, 267, 20465-20470.
    • (1992) J. Biol. Chem. , vol.267 , pp. 20465-20470
    • Bartlett, J.D.1    Leuthy, J.D.2    Carlson, S.G.3    Sollott, S.J.4    Holbrook, N.J.5
  • 70
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein, B.; Kinzler, K.W. p53 function and dysfunction. Cell 1992, 70, 523-526.
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 71
    • 0027298576 scopus 로고
    • Induction of cellular p53 activity by DNA-damaging agents and growth arrest
    • Zhan, Q.; Carrier, F.; Fornace, A.J. Induction of cellular p53 activity by DNA-damaging agents and growth arrest. Mol. Cell. Biol.. 1993, 13, 4242-4250.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4242-4250
    • Zhan, Q.1    Carrier, F.2    Fornace, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.