Characterization of VHε gene expressed in PBL from children with atopic diseases: Detection of homologous VH1-69 derived transcripts from three unrelated patients

Immunology Letters

Volumn 94, Issue 1-2, 2004, Pages 99-106

  Bando, Yuki ^a,b   Shimizu, Akira ^c,d   Ra, Chisei ^e  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY HOSPITAL   (Japan)

^e NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Allergy; Antibodies; CDR; CM; complementarity determining region; cow's milk; D; diversity; FR; framework region; HDM; heavy chain variable region gene; house dust mite; J; joining; radioallergosorbent test; RAST; Repertoire development; VH

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN HEAVY CHAIN; COMPLEMENTARY DNA; MESSENGER RNA;

ARTICLE; ATOPIC DERMATITIS; CASE REPORT; CLONE; COMPLEMENTARITY DETERMINING REGION; DNA POLYMORPHISM; FOOD ALLERGY; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC VARIABILITY; HUMAN; MALE; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SOMATIC MUTATION; AMINO ACID SEQUENCE; GENETICS; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOLOGY; INFANT; MOLECULAR GENETICS; MONONUCLEAR CELL; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; BASE SEQUENCE; CHILD, PRESCHOOL; COMPLEMENTARITY DETERMINING REGIONS; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN EPSILON-CHAINS; IMMUNOGLOBULIN HEAVY CHAINS; INFANT; LEUKOCYTES, MONONUCLEAR; MALE; MOLECULAR SEQUENCE DATA; RNA, MESSENGER; SEQUENCE ALIGNMENT;

EID: 3242734675     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2004.04.006     Document Type: Article

References (28)

1. Sporik R., Holgate S.T., Platts-Mills T.A.E., Cogswell J.J. Exposure to house-dust mite allergen (Der p1) and the development of asthma in childhood. N Engl J Med. 325:1990;502-507
2. Arshed S.H., Hide D.W. Effect of environmental factors on the development of allergic disorders in infancy. J Allergy Clin Immunol. 90:1992;235-241
3. Kuehr J., Frischer W., Meinert R., Barth R., Forster J., Schroub S., Urbanek R., Karman W. Mite allergen exposure is a risk factor for the incidence of specific sensitization. J Alleregy Clin Immunol. 94:1994;44-52
4. Bacharier L.B., Jabara H., Geha R.S. Molecular mechanisma of immunoglobulin E regulation. Rev. Int Arch Allergy Immunol. 115:1998;257-269
5. Nakajima-Adachi H., Hachimura S., Ise W., Honma K., Nishiwaki S., Hirota M., Shimojo N., Katsuki T., Ametani A., Kohno Y., Kaminogawa S. Determinant analysis of IgE and IgG4 antibodies and T cells specific for bovine alpha(s)1-casein from the same patients allergic to cow's milk: existence of alpha(s)1-casein-specific B cells and T cells characteristic in cow's-milk allergy. J Allergy Clin Immunol. 101:1998;660-671
6. Ball G., Shelton M.J., Walsh B.J., Hill D.J., Hosking C.S., Howden M.E. A major continuous allergenic epitope of bovine β-lactoglobulin recognized by human IgE binding. Clin Exp Allergy. 24:1994;758-764
7. Ong E.K., Knox R.B., Singh M.B. Mapping of the antigenic and allergenic epitopes of Lol p VB using gene fragmentation. Mol Immunol. 32:1995;295-302
8. Steinberger P., Kraft D., Valenta R. Construction of a combinatorial IgE library from an allergic patient. J Biol Chem. 271:1996;10967-10972
9. Nishiyama C., Hatanaka H., Ichikawa S., Fukada M., Akagawa-Chihara M., Yuuki T., Yokota T., Inagaki F., Okumura Y. Analysis of IgE epitope of Der f 2 with anti-Der f 2 mouse monoclonal antibodies. Mol Immunol. 36:1999;53-60
10. Matsuda F., Shin E.K., Nagaoka H., Matsumura R., Haino M., Fukita Y., Takaishi S., Imai T., Riley J.H., Anand R., Soeda E., Honjo T. Structure and physical map of 64 variable segments in the 3' 0.8-megabase region of the human immunogloblin heavy-chain locus. Nature Genet. 3:1993;88-94
11. Matsuda F., Ishii K., Bourvagnet P., Kuma K., Hayashida H., Miyata T., Honjo T. The comlete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J. Exp. Med. 188:1998;2151-2162
12. van der Stoep N., van der Linden J., Logtenberg T. Molecular evolution of the human immunoglobulin E response: high incidence of shared mutations and clonal relatedness among εVH5 transcripts from three unrelated patients with atopic dermatitis. J Exp Med. 177:1993;99-107
13. Snow E.R., Chapman C.J., Frew A.J., Holgate S.T., Stevenson F.K. Analysis of Ig Vh region genes encoding IgE antibodies in splenic B lymphocytes of a patient with asthma. J Immunol. 154:1995;5576-5581
14. Tilgner J., Golembowski S., Kersten B., Sterry W., Jahn S. Vh genes expressed in peripheral blood IgE-producing B cells from patients with atopic dermatitis. Clin Exp Immunol. 107:1996;528-535
15. Eibensteiner E., Spitzauer S., Steinberger P., Kraft D., Valenta R. Imunoglobulin E antibodies of atopic individuals exhibit a broad usage of Vh-gene families. Immunology. 101:2000;112-119
16. Tomlinson I., Walter G., Marks J.D., Liewelyn M.B., Winter G. The repertoire of human germline Vh sequences reveals about 50 groups of Vh segment with different hypervariable loops. J Mol Biol. 227:1992;776-798
17. Corbett S.J., Tomlinson I.M., Sonnhammer E.L.L., Buck D., Winter G. Sequence of human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. J Mol Biol. 270:1997;587-597
18. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C. Sequence of proteins of immunological interest, fifth ed. Washington, DC: NIH Publications, 1991. p. 1137.
19. van der Stoep N., van der Linden J., Logtenberg T. Molecular evolution of the human immunoglobulin E response: high incidence of shared mutations and clonal relatedness among ε VH5 transcripts from three unrelated patients with atopic dermatitis. J Exp Med. 177:1993;99-107
20. Rundle C.H., Schtoeder H.W., Koopman W.J. In situ hybridization analysis of immunoglobulin heavy chain variable gene expression with family specific oligonucleotide probes. J Immunol Methods. 218:1998;31-52
21. Brezinschek H.P., Brezinschek R.I., Lipsky P.E. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol. 155:1995;190-202
22. Van der Stoep N., Korver W., Logtenberg T. In vivo and in vitro IgE isotype switching in human B lymphocytes: evidence for a predominantly direct IgM to IgE class switch program. Eur J Immunol. 24:1994;1307-1311
23. Baskin B., Islam K.B., Evengard B., Emtestam L., Smith C.I. Direct and sequential switching from mu to epsilon in patients with Schistosoma mansoni infection and atopic disease. Eur J Immunol. 27:1997;130-135
24. Simizu A., Honjo T. Synthesis and regulation of trans-mRNA encoding the immunoglobulin E heavy chain. FASEB J. 7:1993;149-154
25. Marshall A.J., Doyen N., Bentolila L.A., Paige C.J., Wu G.E. Terminal deoxynucleotidyl transferase expression during neonatal life alters Dh reading frame usage and Ig-receptors-dependent selection of V regions. J Immunol. 161:1998;6657-6663
26. Sasso E.H., Willem van Dijk K., Bull A.P., Milner E.C.B. A fetally expressed immunoglobulin Vh1 gene belongs to a complex set of alleles. J Clin Invest. 91:1992;2358-2367
27. Yang P.M., Olee T., Carson D.A., Chen P.P. Characterization of two highly homologous autoantibody-related Vh1 genes in humans. Scand J Immunol. 37:1993;504-508
28. McElveen J.E., Clark M.R., Smith S.J., Sewell H.F., Shakib F. Primary sequence and molecular model of the variable region of a mouse monoclonal anti-Der p 1 antibody showing a similar epitope specificity as human IgE. Clin Exp Allergy. 28:1998;1427-1434