Gemcitabine and continuous infusion of 5-fluorouracil in locally advanced and metastatic pancreatic cancer: A phase I-II study

Anticancer Research

Volumn 24, Issue 3 B, 2004, Pages 2107-2112

  Oliani, Cristina ^a,b   Padovani, M ^a   Manno, P ^a   Barana, D ^a   Falconi, M ^a   Bassi, C ^a   Cavallini, G ^a   Pederzoli, P ^a   Cetto, G L ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

5 fluorouracil; Gemcitabine; Pancreatic cancer

Indexed keywords

CISPLATIN; DEXAMETHASONE; DOXIFLURIDINE; EPIRUBICIN; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IRINOTECAN; METOCLOPRAMIDE;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASTHENIA; BLOOD TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER PATIENT; CANCER SURVIVAL; CHEMOTHERAPY INDUCED EMESIS; CLINICAL PROTOCOL; CLINICAL TRIAL; DIARRHEA; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG INFUSION; DRUG TOLERABILITY; ERYSIPELAS; FOLLOW UP; HUMAN; HUMAN TISSUE; KIDNEY COLIC; LEG EDEMA; LIVER TOXICITY; METASTASIS; MUCOSA INFLAMMATION; NEUTROPENIA; PANCREAS CANCER; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SKIN TOXICITY; STOMATITIS; THROMBOCYTOPENIA; TREATMENT OUTCOME; VOMITING;

ADENOCARCINOMA; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DEOXYCYTIDINE; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS;

EID: 3242704256     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. American Cancer Society. Cancer Facts and Figures New York, NY: National Media Office; 1995. Brochure.
2. Talamini G, Bassi C, Falconi M, Sartori N, Salvia R, Rigo L, Castagnini A, Di Francesco V, Frulloni L, Bovo P, Vaona B, Angelini G, Vantini I, Cavallini G and Pederzoli P: Alcohol and smoking as risk factors in chronic pancreatitis and pancreatic cancer. Dig Dis Sci 44(7): 1303-11, 1999.
3. De Vita VT, Hellman S and Rosenberg SA: Cancer: Principles and Practice of Oncology. 4th ed. Philadelphia, PA: J.B. Lippincott Co 2708-2710, 1993.
4. Casper ES, Green MR, Kelsen DP, Heelan RT, Brown TD, Flombaum CD, Trochanowski B and Tarassoff PG: Phase II trial of gemcitabine (2,2'-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas. Invest New Drugs 12(1): 29-34, 1994.
5. Carmichael J, Fink U, Russell RC et al: Phase II study of gemcitabine in patients with advanced pancreatic cancer. Proc ASCO 12 (A698), 1993.
6. Burris HA, Moore MJ, Andersen J, Green MR, Rothembergh L, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, Nelson R, Dorr FA, Stephens CD and Von Hoff DD: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreatic cancer: a randomized trial. J Clin Oncol 15: 2403-2413, 1997.
7. Rothemberg ML, Moore MJ, Cripps, Andersen JS, Portenoy RK, Burris HA, Green MR, Tarassoff PG, Brown TD, Casper ES, Storniolo AM and Von Hoff DD: A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer. Ann Oncol 7: 347-353, 1996.
8. Hansen R, Quebbeman E et al: Continuous 5-fluorouracil infusion in carcinoma of the pancreas: A phase II study. AM J Med Sci 295: 91-93, 1988.
9. Hidalgo M, Castellano D, Paz-Ares L, Gravalos C et al: Phase I-II study of gemcitabine and fluorouracil as a continuous infusion in patients with pancreatic cancer. J Clin Oncol 17(2): 585-592,1999.
10. Abbasi K: Di Bella's miracle method. BMJ 316(7144): 1617, 1998.
11. Lionetto R, Pugliese V, Bruzzi et al: No standard treatment is available for advanced pancreatic cancer. Eur J Cancer 31A(6): 882-887, 1995.
12. Ischia S, Polati E, Finco G and Gottin L: Celiac block for the treatment of pancreatic pain. Curr Rev Pain 4(2): 127-33, 2000.
13. Philip PA, Zalupski MM, Vaitkevicius VK, Arlauskas P, Chaplen R, Heilbrun LK, Adsay V et al: Phase II study of gemcitabine and cisplatin in the treatment of patients with advanced pancreatic carcinoma. Cancer 92(3): 569-77, 2001.
14. Heinemann V, Wilke H, Possinger K, Nergenthaler K, Clemens M, Konig HI et al: Gemcitabine and cisplatin in the treatment of advanced and metastatic pancreatic cancer. Final results of a Phase II study. Proc Am Soc Clin Oncol 18: 1052, 1999.
15. Lokich J: Infusional 5-FU: historical evolution, rationale, and clinical experience. Oncology 12(10 suppl 7): 19-22, 1998.
16. Roila F: Risposte obiettive e clinical benefit da chemioterapia: avrei qualcosa da dire. Tumori 87(3 suppl 1): S42, 2001.
17. Marantz A, Jovtis S, Almira E, Balbiani L et al: Phase II study of gemcitabine, 5-fluorouracil, and leucovorin in patients with pancreatic cancer. Semin Oncol 28(3 suppl 10): 44-49, 2001.
18. Cascinu S, Siva R, Barni S, Labianca R, Frontini L, Piazza E et al: A combination of gemcitabine and 5-fluorouracil in advanced pancreatic cancer, a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD). Br J Cancer 80: 1595-8, 1999.
19. Louvet C, Andrè T, Hammel P, Selle F et al: Phase II trial of bimonthly leucovorin, 5-fluorouracil and gemcitabine for advanced pancreatic adenocarcinoma (FOLFUGEM). Annals Oncol 12: 675-679, 2001.
20. Berlin JD, Catalano P, Thomas JP, Kugler JW, Haller DG and Benson AB 3rd: Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 20(15): 3270-5, 2002.
21. Scheithauer W, Schüll B, Ulrich-Pur H, Shimd K, Raderer M et al: Gemcitabine alone or in combination with capecitabine in patients with advanced pancreatic adenocarcinoma. Proc ASCO Abs 500, 2002.
22. Gonzalez-Baron M, Mel R, Bolanos M, Lopez Gomez L, Feliu J, Escudero MP et al: Phase II study of a fixed-dose infusion of gemcitabine associated to UFT in advanced pancreatic cancer. Proc ASCO Abs 601, 2002.
23. Sherman WH and Fine RL: Combination gemcitabine and docetaxel therapy in advanced adenocarcinoma of the pancreas. Oncology 60: 316-321, 2001.
24. Rougier P, Adenis A, Ducreux M, De Forni M, Bonneterre J, Dembak M, Clouet P, Lebecq A, Baille P, Lefresne-Soulas F, Blanc C and Armand JP: A Phase II study: docetaxel as first-line chemotherapy for advanced pancreatic adenocarcinoma. Eur J Cancer 36: 1016-1025, 2000.
25. Rocha Lima CM, Sherman CA, Brescia FJ, Brunson CY and Green MR: Irinotecan/gemcitabine combination chemotherapy in pancreatic cancer. Oncology 15(3 suppl 5): 46-51, 2001.
26. Louvet C, Andre T, Lledo G, Hammel P, Bleiberg H, Bouleuc C, Gamelin E, Flesch M, Cvitkovic E and De Gramont A: Gemcitabine combined with oxaliplatin in advanced pancreatic adenocarcinoma: final results of a GERCOR multicenter phase II study. J Clin Oncol 20(6): 1512-8, 2002.
27. Reni M, Passoni P, Panucci MG, Nicoletti R, Galli L, Balzano G, Zerbi A, Di Carlo V and Villa E: Definitive results of a phase II trial of cisplatin, epirubicin, continuous-infusion fluorouracil, and gemcitabine in stage IV pancreatic adenocarcinoma. J Clin Oncol 19(10): 2679-86, 2001.
28. Cantore M, Pederzoli P, Cornalba G, Fiorentini G, Guadagni S, Miserocchi L, Frassoldati A, Ceravolo C, Smerieri F and Muchmore JH: Intra-arterial chemotherapy for unresectable pancreatic cancer. Ann Oncol 11(5): 569-73, 2000.
29. Boz G, De Paoli A, Innocente R, Rossi C, Tosolini G, Pederzoli P, Talamini R and Trovo MG: Radiotherapy and continuous infusion 5-fluorouracil in patients with nonresectable pancreatic carcinoma. Int J Radiat Oncol Biol Phys 51(3): 736-40, 2001.
30. Klapdor R, Muller C, Seutter R, Bahlo M, Peters W and Fenner C: Improvement of survival by efficacy orientated sequential polychemotherapy of exocrine pancreatic cancer. Anticancer Res 20: 5201-5208, 2000.
31. Cantore M, Rabbi C, Cavazzini G, Oliani C and Aitini E: Irinotecan and oxaliplatin combination therapy in patients with advanced pre-treated pancreatic cancer. Proc ASCO Abs 2197, 2002.
32. Pelzer U, Hempel C, Stieler J, Köneke D, Riess H, Oettle H et al: Oxaliplatin (OXA) in combination with high dose 5-FU (24h)/folinic acid (FA) as salvage therapy in patients with gemzar-refractory advanced pancreatic cancer. Proc ASCO Abs 684, 2002.
33. Storniolo AM, Enas NH, Brown CA, Voi M, Rothenberg ML and Schilsky R: An investigational new drug treatment program for patients with gemcitabine: results for over 3000 patients with pancreatic carcinoma. Cancer 85(6): 1261-8, 1999.