Loxosceles deserta spider venom induces the expression of vascular endothelial growth factor (VEGF) in keratinocytes

Inflammation

Volumn 24, Issue 1, 2000, Pages 1-9

  Desai, Anjali ^a   Lankford, Heather A ^a   Warren, Jeffrey S ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; LYMPHOTOXIN; SPIDER VENOM; VASCULOTROPIN;

ARTICLE; BLOOD VESSEL PERMEABILITY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; KERATINOCYTE; LUNG ALVEOLUS EPITHELIUM; PROTEIN EXPRESSION; SKIN NECROSIS; VASODILATATION;

AORTA; CELLS, CULTURED; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-1; KERATINOCYTES; LUNG; LYMPHOKINES; MUSCLE, SMOOTH, VASCULAR; PHOSPHORIC DIESTER HYDROLASES; RECOMBINANT PROTEINS; RNA, MESSENGER; SPIDER VENOMS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ARACHNIDA; ARANEAE; LOXOSCELES;

EID: 0033952465     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006995023982     Document Type: Article

References (18)

1. Blackman, J. R. 1995. Spider Bites. J. Am. Board. Fam. Pract. 8, 4:288-294.
2. Wright, S. W., K. D. Wrenn, L. Murray, and D. Seger. 1997. Clinical presentation and outcome of brown recluse spider bite. Annals Emergency Med. 30, 1:28-32.
3. Gomez, H. F., M. J. Miller, A. Desai, and J. S. Warren. 1997. Loxosceles venom induces production of multiple chemokines by endothelial and epithelial cells. Clin. Toxicol. 35, 5:557.
4. Desai, A., M. J. Miller, H. F. Gomez, and J. S. Warren. 1999. Loxosceles deserta venom induces NF-κB dependent chemokine expression in endothelial cells. J. Tox. Clin. Tox. (In press).
5. Viac, J., S. Schnitt, and A. Claudy. 1997. Expression of vascular endothelial growth factor in normal epidermis, epithelial tumors and cultured keratinocytes. Arch. Dermatol. Res. 289:158-163.
6. Jaffe, E. A. Culture and identification of large vessel endothelial cells. In: Biology of endothelial cells. 1984. (Ed.) E. A. Jaffe, Martinus Nijhoff Publishers, Boston, p. 13.
7. Li, J., M. A. Perrella, J. Tsai, S. Yet, C. Hsieh, M. Yoshizumi, C. Patterson, W. O. Endege, F. Zou, and M. Lee. 1995. Induction of vascular endothelial growth factor gene expression by interleukin-1β in rat aortic smooth muscle cells. J. Biol. Chem. 270, 1:308-312.
8. Cao, Y., P. Linden, J. Farnebo, R. Cao, A. Eriksson, V. Kumar, J. Qi, L. Claesson-Welsh, and K. Alitalo. 1998. Vascular endothelial growth factor C induces angiogenesis in vivo. Proc. Natl. Acad. Sci. U.S.A. 95:14389-14394.
9. Patel., K. D., V. Modur, G. A. Zimmerman, S. M. Prescott, and T. M. McIntyre. 1994. The necrotic venom of the brown recluse spider induces dysregulated endothelial cell-dependent neutrophil activation. J. Clin. Invest. 94:631-642.
10. Futrell, J. M. 1992. Loxoscelism. Am. J. Med. Sci. 304, 4:261-267.
11. Plate, K. H., and P. C. Warnke. 1997. Vascular endothelial growth factor. J. Neuro-Oncology. 35:365-372.
12. Brown, L. F., K. Yeo, B. Berse, T. Yeo, D. Senger, H. Dvorak, and L. Van De Water. 1992. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J. Exp. Med. 176:1375-1379.
13. Connolly, D. T. 1997. Vascular permeability factor: a unique regulator of blood vessel function. J. Cell Biochem. 47:219-223.
14. Detmar, M., L. Brown, K. Claffey, K. Yeo, O. Kocher, R. Jackman, B. Berse, and H. Dvorak. 1994. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J. Exp. Med. 180:1141-1146.
15. Brown, L., T. Harrist, K. Yeo, M. Ståhle-Bäckdahl, R. Jackman, B. Berse, K. Tognazzi, H. Dvorak, and M. Detmar. 1995. Increased expression of vascular permeability factor (vascular endothelial growth factor) in bullous pemphigoid, dermatitis herpetiformis, and erythema multiforme. J. Invest. Dermatol. 104:744-749.
16. Barker, J. N. W. N., R. S. Mitra, C. E. M. Griffiths, V. M. Dixit, and B. J. Nickoloff. 1991. Keratinocytes as initiators of inflammation. The Lancet. 337:211-214.
17. Detmar, M., K. Yeo, J. Nagy, L. Van De Water, L. Brown, B. Berse, B. Elicker, S. Ledbetter, and H. Dvorak. 1995. Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells. J. Invest. Dermatol. 105:44-50.
18. Frank, S., G. Hübner, G. Breier, M. Longaker, D. Greenhalgh, and S. Werner. 1995. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. J. Biol. Chem. 270:12607-12613.