Effects of octreotide on expression of L-type voltage-operated calcium channels and on intracellular Ca 2+ in activated hepatic stellate cells

Chinese Medical Journal

Volumn 117, Issue 6, 2004, Pages 913-916

  Ding, Hui Gou ^a,c   Wang, Bao En ^b   Jia, Ji Dong ^b   Harry Xia, Hua Xiang ^c   Benjamin Wong, Chun Yu ^c   Zhao, Chun Hui ^a   Xu, Yan Lin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Endothelin 1; Hepaticstellate cell; Immunocytochemistry; Intracellular Ca2+; L VOCC; LSCM; Octreotid; Portal hypertension

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; OCTREOTIDE; POTASSIUM CHLORIDE; SOMATOSTATIN; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL ACTIVATION; CELL DENSITY; CELL LINE; CELL STIMULATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; DRUG TARGETING; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; LIVER CELL; LIVER CIRRHOSIS; NONHUMAN; PORTAL HYPERTENSION; PROTEIN EXPRESSION; STELLATE CELL;

EID: 3242698812     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Li D, Friedman SL. Liver fibrogenisis and the role of hepatic stellate cells: new insights and prospects for therapy. J Gastroenterol Hepatol 1999;14:618-633.
2. Rockey DC. The cellular pathogenesis of portal hypertension: stellate cell contractility, endothelin, and nitric oxide. Hepatology 1997:25:2-5.
3. Ekataksin W, Kaneda K. Liver microvascular architecture: An insight into the pathophysiology of portal hypertension. Seminars in liver disease 1999;4:359-382.
4. Pinzani M, Marra F, Carloni V. Signal transduction in hepatic stellate cells. Liver 1998;18:2-13.
5. Reynaert H, Thompson MG, Thomas T, et al. Hepatic stellate cells: role in microcirculation and pathyophysiology of portal hypertension. Gut 2002;50:571-581.
6. Thimgan MS, Yee HF Jr. Quantitation of rat hepatic stellate cell contraction: stellate cell contribution to sinusoidal resistance. Am J Physiol 1999;277:G137-143.
7. Reichen J, Gerbes AL, Steiner ML, et al. The effect of endothelin and its antagonist Bosentan on hemodynamics and microvascular exchange in cirrhotic rat liver. J Hepatol 1998; 28:1020-1030.
8. Gorbig MN, Gines P, Bataller R, et al. Human hepatic stellate cella secrete adrenomedullin: potential autocrine factor in the regulation of cell contractility. J Hepatol 2001; 222-229.
9. Sakamoto M, Ueno T, Nakamura T, et al. Estrogen upregulates nitric oxide synthase expression in cultured rat hepatic sinusoidal endothelial cells. J Hepatol 2001;34:858-864.
10. Bataller R, Gines P, Nicolas JM, et al. Angiotension II induces contraction and proliferation of human hepatic stellate cells. Gastroenterology 2000;118:1149-1156.
11. 2+ and rho signaling pathways: two paths to hepatic stellate cell contraction. Hepatology 2001;33:1007-1008.
12. Bataller R, Gasull X, Gines P, et al. In vitro and in vivo activation of rat hepatic stellate cells results in De Novo expression of L-type voltage-operated calcium channels. Hepatology 2001;33:956-962.
13. Failli P, Ruocco C, De Franco R, et al. The mitogenic effect of platelet-derived growth factor on human hepatic stellate cells requires calcium influx. Am J Physiol 1995;269:C1133-C1139.
14. Abernethy DR, Schwartz JB. Calcium-antagonist drugs. N Engl J 1999;4:1447-1457.
15. Reynaert H, Vaeyens F, Qin H. Functionally active somatosatin receptor subtype1, 2 and 3 on activated hepatic stellate cells. In cells of the hepatic sinusoid. Editored by Wisse E. The Netherlands 2001;8:187-190.
16. Cui RT, Wang BE, Ding HG, et al. Usefulness of determining a protein induced by vitamin K absence in detection of hepatocellular carcinoma. Chin Med J 2002;1: 42-45.