Exposure levels of asthmatic children to allergens, endotoxins, and serine proteases in a tropical environment

Journal of Asthma

Volumn 41, Issue 4, 2004, Pages 485-496

  Montealegre, Federico ^a   Fernández, Blanca ^a   Delgado, Alexie ^a   Fernández, Lisa ^a   Román, Ayleen ^a   Chardón, Domingo ^a   Rodríguez Santana, José ^b   Medina, Vivian ^b   Zavala, Diego ^a   Bayona, Manuel ^c  

^a PONCE SCHOOL OF MEDICINE   (Puerto Rico)

^b Pediatric Pulmonary Program of San Juan   (Puerto Rico)

^c UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

Allergen levels; Endotoxins; Indoor environmental risk factors; Pediatric asthma; Puerto Rico; Serine proteases

Indexed keywords

ALLERGEN; ELASTASE; ENDOTOXIN; SERINE PROTEINASE; TRYPSIN;

ADOLESCENT; AMBIENT AIR; ARTICLE; ASTHMA; BUILDING; CAT; CHILD; COCKROACH; CONCENTRATION RESPONSE; CORRELATION ANALYSIS; DISEASE EXACERBATION; DISEASE SEVERITY; DOG; DUST EXPOSURE; ENVIRONMENTAL EXPOSURE; FEMALE; HOME; HUMAN; MAJOR CLINICAL STUDY; MALE; MITE; MOULD; PUERTO RICO; QUANTITATIVE ANALYSIS; QUESTIONNAIRE; RISK FACTOR; ROOM VENTILATION; SAMPLING; SYMPTOM;

ADOLESCENT; AIR POLLUTION, INDOOR; ALLERGENS; ASTHMA; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; ENDOTOXINS; ENVIRONMENTAL MONITORING; FEMALE; HUMANS; INFANT; MALE; PUERTO RICO; SERINE ENDOPEPTIDASES; TROPICAL CLIMATE;

EID: 3242698742     PISSN: 02770903     EISSN: None     Source Type: Journal    
DOI: 10.1081/JAS-120033993     Document Type: Article

References (58)

1. Abramson M, Kutin JJ, Raven J, Lanigan A, Czarny D, Walters EH. Risk factors for asthma among young adults in Melbourne. Respirology 1996; 1(4):291-297.
2. Sarpong SB, Karrison T. Sensitization to indoor allergens and the risk for asthma hospitalization in children. Ann Allergy Asthma Immunol 1997; 79(5):455-459.
3. CDC. Self-reported asthma prevalence among adults-Unites States. MMWR 2000; 50(32):682-686.
4. Montealegre F, Bayona M. An estimate of the prevalence, severity and seasonality of asthma in visitors to a Ponce Shopping Center. PR Health Sci J 1996; 15(2):113-117.
5. Orengo JC, Loyo NI, Serrano RA, Mercado HE, Horta H. Prevalence of Respiratory and Allergic Problems Among School Children in the Cataño Air Basin. Presented at the Cataño Workshop, San Juan, Puerto Rico, 1996.
6. Pérez-Perdomo R, Suárez-Pérez E, Torres D, Morell C. Prevalencia de asma y utilización de servicios médicos en asegurados de una compañía de servicios de salud en Puerto Rico, 1996-1997. Bol Asoc Med Puerto Rico 1999; 91(7-12):91-97.
7. Montealegre F, Sepúlveda A, Quiñones C, Bayona M, Fernández-Caldas E. Identification of the domestic fauna of Puerto Rico. PR Health Sci J 1997; 16(2):109-116.
8. Montealegre F, Quiñones C, Michelen V, Bayona M, Fernández-Caldas E, Vázquez O, Colón F, Chardón D, García M. Prevalence of skin reactions to aeroallergens in asthmatics of Puerto Rico. PR Health Sci J 1998; 16(4):359-367.
9. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R. Proteinase-activated receptors. Pharmacol Rev 2001; 53(2):245-282.
10. Cicala C, Bucci M, De Dominicis G, Harriot P, Sorrentino L, Cirino G. Bronchoconstrictor effect of thrombin and thrombin receptor activating peptide in guinea-pigs in vivo. Br J Pharmacol 1999; 126(2):478-484.
11. Standardization of spirometry-1987 update. Statement of the American Thoracic Society. Am Rev Respir Dis 1987; 136(5):1285-1298.
12. Dean AG, Dean JA, Coulmbier D, Brendel KA, Smith DC, Burton AH, Dicker RC, Sullivan K, Fagan RF, Amer TG. Epi Info, Version 6: A Word Processing, Database, and Statistics Program for Epidemiology on Microcomputers. Centers for Disease Control And Prevention: Atlanta, GE, USA, 1994.
13. Methods in Observational Epidemiology. Kelsey J, Thompson W, Douglas EA, eds. Oxford Press: New York, 1986:222.
14. Milton D, Feldman DS, Neuberg RJ, Bruckner RJ, Greaves IA. Environmental endotoxin measurement; the kinetic Limulus assay with resistant-parallel-line estimation. Environ Res 1992; 57(2):212-230.
15. Finney DL. Statistical Method in Biological Assay. Charles Griffin and Co., Ltd.: London, 1978, 69-104.
16. Exterkate FA. Differences in short peptide-substrate cleveage by two cell envelope proteinases of Lactococcus lactis subs.cremoris are related to specificity. Appl Microbiol Biotechnol 1990; 33(4):401-406.
17. Platts-Mills TAE, Thomas WR, Alberse RC, Vervolet D, Chapman MD. Dust mite allergens and asthma: report of the second international workshop. J Allergy Clin Immunol 1992; 89(5):1046-1060.
18. Eggleston PA, Rosenstreich D, Lynn H, Gergen P, Baker D, Kattan M, Mortimer KM, Mitchell H, Ownby D, Slavin R, Malveaux F. Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma. J Allergy Clin Immunol 1998; 102(4 Pt 1):563-570.
19. Park JH, Gold DR, Spiegelman DL, Burge HA, Milton DK. House dust endotoxin and wheeze in the first year of life. Am J Respir Crit Care Med 2001; 163(2):322-328.
20. National Asthma Education and Prevention Program. Expert Panel Report: Guidelines for the Diagnosis and Management of Asthma. NIH Publication No. 91-3042. Bethesda, MD: National Heart, Lung and Blood Institute, 1991.
21. Barnes KC, Femández-Caldas E, Trudeau WL, Milne DE, Brenner RJ. Spatial and temporal distribution of house dust mite (Astigmata, Pyroglyphidae), allergens Der p1 and Der f1 in Barbadian homes. J Med Entomol 1997; 34(2):212-218.
22. Fernández-Caldas E, Codina R, Ledford DK, Trudeau WL, Lockey RF. House dust mite, cat and cockroach allergen concentrations in daycare centers in Tampa, Florida. Ann Allergy Asthma Immunol 2001; 87(3):196-200.
23. Wickens K, Mason K, Fitzharris P, Siebers R, Hearfiels M, Cunningham M, Crane J. The importance of housing characteristics in determining Der p1 levels in carpets in New Zeland homes. Clin Exp Allergy 2001; 31(6):803-805.
24. Raunio P, Pasanen AL, Reiman M, Virtanen T. Cat, dog, and house-dust-mite allergen levels of house dust in Finnish apartments. Allergy 1998; 53(2):195-199.
25. Litonjua AA, Carey VJ, Burge HA, Weiss ST, Gold DR. Exposure to cockroach allergen in the home is associated with incident doctor-diagnosed asthma and recurrent wheezing. J Allergy Clin Immunol 2001; 107(1):41-47.
26. Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, Mitchell H, McNiff-Mortimer K, Lynn H, Ownby D, Malveaux F. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among innercity children with asthma. N Engl J Med 1997; 337:1356-1363.
27. Sears MR, Herbison GP, Holdaway MD, Hewitt CJ, Flannery EM, Silva PA. The relative risk of sensitivity to grass pollen, house dust mite and cat dander in the development of childhood asthma. Clin Exp Allergy 1989; 9(4):419-424.
28. Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, Mitchell H, McNiff-Mortimer K, Lynn H, Ownby D, Malveaux F. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med. 1997; 336(19):1356-1363.
29. Sears MR, Herbison GP, Holdaway MD, Hewitt CJ, Flannery EM, Silva PA. The relative risk of sensitivity to grass pollen, house dust mite and cat dander in the development of childhood asthma. Clin Exp Allergy 1989; 9(4):419-424.
30. Ronchetti R, Bonci E, Cutrera R, De Castro G, Indinnmemeo L, Midulla F, Tancredi G, Martinez FD. Enhanced allergic sensitization related to parental smoking. Arch Dis Child 1992; 67(4):496-500.
31. Wahn U, Lau S, Bergmann R, Kulig M, Forster J, Bergmann K, Bauer CP, Guggenmoos-Holzmann I. Indoor allergen exposure is a risk factor for sensitization during the first three years of life. J Allergy Clin Immunol 1997; 99(6 Pt 1):763-769.
32. Lindfors A, Wickman M, Hedlin G, Pershagen G, Rietz H, Nordvall SL. Indoor environmental risk factors in young asthmatics: a case-control study. Arch Dis. Child 1995; 73(5):408-412.
33. Travis J, Salvesen GS. Human serum protease inhibitors. Ann Rev Biochem 1983;(52):655-709.
34. Hutchison DC. The role of proteases and anti-proteases in bronchial secretions. Eur J Respir Dis Suppl. 1987; 153:78-85.
35. Thompson PJ. Unique role of allergens and the epithelium in asthma. Clin Exp Allergy 1998; 28(suppl. 5):110-116.
36. 1-antitrypsin. Arch Int Med 1990; 150(11):2349-2354.
37. Michel O, Dentener M, Corazza F, Buurman W, Rylander R. Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy. J Allergy Clin Immunol 2001; 107(5):797-804.
38. Michel O, Kips J, Duchateau J, Vertongen F, Robert L, Collet H, Pauwels R, Sergysels R. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996; 154(6 Pt 1):1641-1646.
39. Michel O, Duchateau J, Plat G, Cantinieaux B, Hotimsky A, Gerain J, Sergysels R. Blood inflammatory response to inhaled endotoxin in normal subjects. Clin Exp Allergy 1995; 25(1):73-79.
40. Michel O, Ginanni R, Le Bon B, Content J, Duchateau J, Sergysels R. Inflammatory response to acute inhalation of endotoxin in asthmatic patients. Am Rev Respir Dis 1992; 146(2):352-357.
41. Thorn J, Rylander R. Inflammatory response after inhalation of bacterial endotoxin assessed by the induced sputum technique. Thorax 1998; 53(12):1047-1052.
42. Zock JP, Hollander A, Heederik D, Douwes J. Acute lung function changes and low endotoxin exposures in the potato processing industry. Am J Ind Med 1998; 33(4):384-391.
43. Park JH, Spiegelman DL, Gold DR, Burge HA, Milton DK. Predictors of airborne endotoxin in the home. Environ Health Perspect 2001; 109(8):859-864.
44. Reed CE, Milton DK. Endotoxin-stimulated innate immunity: a contributing factor for asthma. J Allergy Clin Immunol 2000; 108(2):157-166.
45. Gereda JE, Klinnert MD, Price MR, Leung DY, Liu AH. Metropolitan home living conditions associated with indoor endotoxin levels. J Allergy Clin Immunol 2001; 107(5):790-796.
46. Riedler J, Braun-Fahrlander C, Eder W, Schreuer M, Waser M, Maisch S, Carr D, Schierl R, Nowak D, von Mutius E, ALEX Study Team E. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001; 358(9288):1129-1133.
47. Von Mutius E, Braun-Fahrlander C, Schierl R, Riedler J, Ehlermann S, Maisch S, Waser M, Nowak D. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 2000; 30(9):1230-1234.
48. Braun-Fahrlander C, Riedler J, Herz U, Eder W, Waser M, Grize L, Maisch S, Carr D, Gerlach F, Bufe A, Lauener RP, Schierl R, Renz H, Nowak D, von Mutius E, Allergy and Endotoxin Study Team. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347(12):869-877.
49. Douwes J, Pearce N, Heederik D. Does environmental endotoxin exposure prevent asthma? Thorax 2002; 57:86-90.
50. Meijer G, van der Heide S, Postma DS, de Reus DM, Koeter GH, van Aalderen WH. House dust mite exposure in asthmatic and healthy children: the difference is carpeting. Pediatr Allergy Immunol 1995; 6(4):187-191.
51. Beer SI, Kannai YI, Waron MJ. Acute exacerbation of bronchial asthma in children associated with afternoon weather changes. Am Rev Respir Dis 1991; 144(1):31-35.
52. Ito S, Kawaoi T, Kondo Y, Hiruma F, Togo T, Takashima H, Kondo T. Outbreaks of asthma attack and meteorological parameters-comparison between two areas Arerugi. 1992; 41(4):475-484.
53. Garty BZ, Kosman E, Ganor E, Berger V, Garty L, Wietzen T, Waisman Y, Mimouni M, Waisel Y. Emergency room visits of asthmatic children, relation to air pollution, weather, and airborne allergens. Ann Allergy Asthma Immunol 1998; 81(6):563-570.
54. Ross MA, Curtis L, Scheff PA, Hryhorczuk DO, Ramakrishnan V, Wadden RA, Persky VW. Association of asthma symptoms and severity with indoor bioaerosols. Allergy 2000; 55(8):705-711.
55. Htut T, Higenbottam TW, Gill GW, Darwin R, Anderson PB, Syed N. Eradication of house dust mite from homes of atopic asthmatic subjects: a double-blind trial. J Allergy Clin Immunol 2001; 107(1):55-60.
56. Harving H, Korsgaard J, Dahl R. House-dust mite exposure reduction in specially designed, mechanically ventilated healthy homes. Allergy 1994; 49(9):713-718.
57. Leaderer BP, Belanger K, Triche E, Holford T, Gold DR, Kim Y, Jankun T, Ren P, McSharry Je JE, Platts-Mills TA, Chapman MD, Bracken MB. Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States: impact of socio-economic factors and population density. Environ Health Perspect 2002; 110(4):419-425.
58. Munir AK, Einarsson R, Schou C, Dreborg SK. Mite (Der p1, Derp1), and cat (Fel d1), allergens in the homes of babies with a family history of allergy. Allergy 1993; 91(5):1067-1074.