Site-directed mutagenesis of the rat β1-adrenoceptor. Involvement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol binding

European Journal of Medicinal Chemistry

Volumn 39, Issue 7, 2004, Pages 625-631

  Rezmann Vitti, Linda A ^a   Louis, Simon N S ^a   Nero, Tracy L ^a   Jackman, Graham P ^a   Machida, Curtis A ^b   Louis, William J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

1 Adrenoceptor; (+ ) 4 3 (t butylamino 3 (2 cyano indoloxy) 2 propanolol; (+ ) 125Iodo cyanopindolol; (+ ) 125Iodo cyanopindolol; (+ )cyanopindolol; Molecular modelling; Mutagenesis

Indexed keywords

ALANINE; BETA 1 ADRENERGIC RECEPTOR; CYANOPINDOLOL; CYANOPINDOLOL I 125; MUTANT PROTEIN; PHENYLALANINE; PROPRANOLOL DERIVATIVE; TYROSINE;

ARTICLE; BINDING AFFINITY; IODINATION; MEMBRANE; MOLECULAR INTERACTION; MUTATION; NONHUMAN; RAT; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; IODINE RADIOISOTOPES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PINDOLOL; PROTEIN BINDING; PROTEIN CONFORMATION; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, BETA-1; TYROSINE;

EID: 3242680792     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.03.009     Document Type: Article

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