Tyr199 in transmembrane domain 5 of the β2-adrenergic receptor interacts directly with the pharmacophore of a unique fluorenone-based antagonist

Biochemical Journal

Volumn 354, Issue 3, 2001, Pages 485-491

  Wu, Z ^a   Thiriot, D S ^a   Ruoho, A E ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Antagonist binding site; Photoaffinity labelling

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; PHOTOREACTIVITY;

ADRENERGIC RECEPTOR; BINDING PHARMACOPHORE;

MUTAGENESIS;

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CONCANAMYCIN A; FLUORENONE DERIVATIVE; IODOAMINOFLISOPOLOL I 125; TRYPSIN; TYROSINE; UNCLASSIFIED DRUG; 4 (2 HYDROXY 3 ISOPROPYLAMINOPROPOXY) 7 AMINO 6 IODOFLUORENONE; 4-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY)-7-AMINO-6-IODOFLUORENONE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; FLUORENE DERIVATIVE; METALLOPROTEINASE; PEPTIDE; PEPTIDYL LYS METALLOENDOPEPTIDASE; PEPTIDYL-LYS METALLOENDOPEPTIDASE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BACULOVIRUS; DRUG BINDING SITE; DRUG RECEPTOR BINDING; LEPIDOPTERA; MOLECULAR CLONING; NONHUMAN; PHARMACOPHORE; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; ANIMAL; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; GLYCOSYLATION; METABOLISM; PROTEIN TERTIARY STRUCTURE;

LEPIDOPTERA; MYTHIMNA UNIPUNCTA; SPODOPTERA FRUGIPERDA; UNIDENTIFIED BACULOVIRUS;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BINDING SITES; COMPUTER SIMULATION; FLUORENES; GLYCOSYLATION; METALLOENDOPEPTIDASES; PEPTIDES; PHOTOAFFINITY LABELS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ADRENERGIC, BETA-2; TRYPSIN; TYROSINE;

EID: 0035866516     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3540485     Document Type: Article

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