T cell replicative senescence: Pleiotropic effects on human aging

Annals of the New York Academy of Sciences

Volumn 1019, Issue , 2004, Pages 123-126

  Effros, Rita B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Immune system; Replicative senescence; T cells

Indexed keywords

CD8 ANTIGEN; CYTOKINE;

AGING; ANTIGEN EXPRESSION; BONE METABOLISM; CELL AGING; CELL DIVISION; CELL SECRETION; CONFERENCE PAPER; CYTOKINE PRODUCTION; HOMEOSTASIS; HUMAN; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; LYMPHOCYTE CULTURE; PLEIOTROPY; SENESCENCE; T LYMPHOCYTE;

EID: 3242680602     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1297.022     Document Type: Conference Paper

References (10)

1. EFFROS, R.B. & G. PAWELEC. 1997. Replicative senescence of T lymphocytes: does the Hayflick Limit lead to immune exhaustion? Immunology Today 18: 450-454.
2. VALENZUELA, H.F. & R.B. EFFROS. 2002. Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus. Clin. Immunol. 105: 117-125.
3. EFFROS, R.B. 1997. Loss of CD28 expression on T lymphocytes: a marker of replicative senescence. Dev. Comp. Immunol. 21: 471-478.
4. FRAUWIRTH, K.A., J.L. RILEY, M.H. HARRIS, et al. 2002. The CD28 signaling pathway regulates glucose metabolism. Immunity 16: 769-777.
5. EFFROS, R.B., R. ALLSOPP, C.P. CHIU, et al. 1996. Shortened telomeres in the expanded CD28-CD8+ subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 10: F17-F22.
6. POSNETT, D.N., J.W. EDINGER, J.S. MANAVALAN, et al. 1999. Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+ CD28- cytotoxic effector clones. Int. Immunol. 11: 229-241.
7. SAURWEIN-TEISSL, M., T.L. LUNG, F. MARX, et al. 2002. Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J. Immunol. 168: 5893-5899.
8. PIETSCHMANN, P., J. GRISAR, R. THIEN, et al. 2001. Immune phenotype and intracellular cytokine production of peripheral blood mononuclear cells from postmenopausal patients with osteoporotic fractures. Exp. Gerontol. 36: 1749-1759.
9. WIKBY, A., B. JOHANSSON, J. OLSSON, et al. 2002. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp. Gerontol. 37: 445-453.
10. DAGARAG, M.D., H. NG, R. LUBONG, et al. 2003. Differential impairment of lytic and cytokine functions in senescent HIV-1-specific cytotoxic T lymphocytes. J. Virol. 77: 3077-3083.