Plasminogen activator inhibitor-1 deficiency enhances flow-induced smooth muscle cell migration

Thrombosis Research

Volumn 114, Issue 1, 2004, Pages 57-65

  Cullen, John P ^a   Nicholl, Suzanne M ^a   Sayeed, Shariq ^a   Sitzmann, James V ^a   Okada, S Steve ^a   Cahill, Paul A ^b   Redmond, Eileen M ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

EC; ECM; endothelial cells; extracellular matrix; human umbilical smooth muscle cells; HUSMC; matrix metalloproteinase; Matrix metalloproteinases; Migration; MMP; PA; PAI 1; plasminogen activator; Pulse pressure; TIMP 2; Vascular smooth muscle

Indexed keywords

BB 3103; MATRIX METALLOPROTEINASE INHIBITOR; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PULSATILE FLOW; SMOOTH MUSCLE FIBER; STATISTICAL SIGNIFICANCE; VASCULAR SMOOTH MUSCLE; WILD TYPE;

ANIMALS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CELL COMMUNICATION; CELL MOVEMENT; CELLS, CULTURED; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; ENZYME ACTIVATION; MATRIX METALLOPROTEINASES; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH, VASCULAR; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 3242670006     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2004.05.003     Document Type: Article

References (36)

1. Schwartz S.M. Smooth muscle migration in atherosclerosis and restenosis. J. Clin. Invest. 100(Suppl. 11):1997;87-89
2. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990's. Nature. 362:1993;801-809
3. Kenagy R.D., Vergel S., Mattsson E., Bendeck M., Reidy M.A., Clowes A.W. The role of plasminogen, plasminogen activators and matrix metalloproteinases in primate arterial smooth muscle migration. Arterioscler Thromb. Vasc. Biol. 16:1996;1373-1382
4. Clowes A.W., Clowes M.M., Au Y.P., Reidy M.A., Belin D. Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery. Circ. Res. 67:1990;61-67
5. Cho A., Reidy M.A. MMP-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury. Circ. Res. 91:2002;845-851
6. Lijnen H.R. Plasmin and matrix metalloproteinases in vascular remodeling. Thromb. Haemost. 86:2001;324-333
7. Carmeliet P., Bouche A., de Clercq C., Janssen S., Pollefeyt S., Wyns S., et al. Biological effects of disruption of the tissue-type plasminogen activator, urokinase-type plasminogen activator and plasminogen activator inhibitor-1 genes in mice. Ann. N. Y. Acad. Sci. 748:1995;367-381
8. Carmeliet P., Moons L., Lijen R., Janssens S., Lupu F., Collen D., et al. Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice. Circulation. 96:1997;3180-3191
9. Hasenstab D., Lea H., Clowes A.W. Local plasminogen activator inhibitor type 1 overexpression in rat carotid artery enhances thrombosis and endothelial regeneration while inhibiting intimal thickening. Arterioscler Thromb. Vasc. Biol. 20:2000;846-852
10. Dollery C.M., McEwan J.R., Henney A.M. Matrix metalloproteinases and cardiovascular disease. Circ. Res. 77:1995;863-868
11. Carmeliet P., Moons L., Herbert J., Crawley J., Lupu F., lijnen R., et al. Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice. Circ. Res. 81:1997;829-839
12. Bendeck M.P., Irvin C., Reidy M.A. Inhibition of matrix metalloproteinase activity inhibits smooth muscle cell migration but not neointimal thickening after arterial injury. Circ. Res. 78:1996;38-43
13. Wilson E., Sudhir K., Ives H.E. Mechanical strain induces growth of vascular smooth muscle cells via autocrine production of PDGF. J. Cell Biol. 123:1993;741-747
14. Cappadona C., Redmond E.M., Theodorakis N.G., McKillop I.H., Hendrickson R., Chhabra A., et al. Phenotype dictates the growth response of vascular smooth muscle cells to pulse pressure in vitro. Exp. Cell Res. 250:1999;174-186
15. Heistad D.D., Lopez J.A., Baumbach G.L. Hemodynamic determinants of vascular changes in hypertension and atherosclerosis. Hypertension. 17:1991;7-11
16. Redmond E.M., Cahill P.A., Hirsch M., Wang Y.-N., Sitzmann J.V., Okada S.S. Effect of pulse pressure on vascular smooth muscle cell migration: the role of urokinase and matrix metalloproteinase. Thromb. Haemost. 81:1999;293-300
17. Redmond E.M., Cullen J.P., Cahill P.A., Sitzmann J.V., Stefansson S., Lawrence D.A., et al. Endothelial cells inhibit flow-induced smooth muscle cell migration: role of plasminogen activator inhibitor-1. Circulation. 103:2001;597-603
18. Carmeliet P., Kieckens L., Schoojans L., Ream B., van Nuffelen A., Prendergast G., et al. Plasminogen activator inhibitor-1 gene-deficient mice. Generation by homologous recombination and characterization. J. Clin. Invest. 92:1993;2746-2755
19. Grobmyer S.R., Kuo A., Orishimo M., Okada S., Cines D.B., Barnathan E.S. Determinants of binding and internalization of tissue-type plasminogen activator by human vascular smooth muscle and endothelial cells. J. Biol. Chem. 268:1993;13291-13300
20. Ojeifo J.O., Su N., Ryan U.S., Verma U.N., Mazumder A., Zwiebel J.A. Towards endothelial-cell-directed cancer immunotherapy: in vitro expression of human recombinant cytokine genes by human and mouse primary endothelial cells. Cytokines Mol. Ther. 2(2):1996;89-101
21. Redmond E.M., Cahill P.A., Sitzmann J.V. Perfused transcapillary smooth muscle cell and endothelial cell co-culture: a novel in vitro model. In Vitro Cell. Dev. Biol. 31:1995;601-609
22. Redmond E.M., Cahill P.A., Sitzmann J.V. Flow-mediated regulation of endothelin receptors in co-cultured vascular smooth muscle cells: an endothelium-dependent effect. J. Vasc. Res. 34:1997;425-435
23. Schneiderman J., Sawdey M.S., Keeton M.R., Bordin G.M., Bernstein E.F., Dilley R.B., et al. Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. PNAS. 89:1992;6998-7002
24. Stefansson S., Lawrence D.A. The serpin PAI-1 inhibits cell migration by blocking integrin v3 binding to vitronectin. Nature. 383:1996;391-441
25. Tanaka S., Koyama H., Ichii T., Shioi A., Hosoi M., Raines E.W., et al. Fibrillar collagen regulation of plasminogen activator inhibitor-1 is involved in altered smooth muscle cell migration. Arterioscler Thromb. Vasc. Biol. 22:2002;1573-1578
26. Sjoland H., Eitzman D.T., Gordon D., Westrick R., Nabel E.G., Ginsburg D. Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1. Arterioscler Thromb. Vasc. Biol. 20:2000;846-852
27. Zhu Y., Farrehi P.M., Fay W.P. Plasminogen activator inhibitor type 1 enhances neointima formation after oxidative vascular injury in atherosclerosis-prone mice. Circulation. 103:2001;3105-3110
28. Eitzman D.T., Westrick R.J., Xu Z., Tyson J., Ginsburg D. Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery. Blood. 96:2000;4212-4215
29. Sobel B.E., Taatjes D.J., Schneider D.J. Intramural plasminogen activator inhibitor type-1 and coronary atherosclerosis. Arterioscler Thromb. Vasc. Biol. 23:2003;1979-1989
30. Lupu F., Bergonzelli G.E., Heim D.A., Cousin E., Genton C.Y., Bachmann F., et al. Localization and production of plasminogen activator inhibitor-1 in human healthy and atherosclerotic arteries. Arterioscler. Thromb. 13:1993;1090-1100
31. Salame M.Y., Samani N.J., Masood I., deBono D.P. Expression of the plasminogen activator system in the human vascular wall. Atherosclerosis. 152:2000;19-28
32. Schafer K., Muller K., Hecke A., Mounier E., Goebel J., Loskutoff D.J., et al. Enhanced thrombosis in atherosclerosis-prone mice is associated with increased arterial expression of plasminogen activator inhibitor-1. Arterioscler Thromb. Vasc. Biol. 23:2003;2097-2103
33. Proia R.R., Nelson P.R., Mulligan-Kehoe M.J., Wagner R.J., Kehas A.J., Powell R.J. The effect of endothelial cell overexpression of plasminogen activator inhibitor-1 on smooth muscle cell migration. J. Vasc. Surg. 36:2002;164-171
34. Kjoller L., Kanse S.M., Kirkegaard T., Rodenburg K.W., Ronne E., Goodman S.L., et al. PAI-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation. Exp. Cell Res. 232:1997;420-429
35. Hasenstab D., Forough R., Clowes A.W. Plasminogen activator inhibitor type 1 and tissue inhibitor of metalloproteinases-2 increase after arterial injury in rats. Circ. Res. 80:1997;490-496
36. Baker A.H., Zaltsman A.B., George S.J., Newby A.C. Divergent effects of TIMP-1, -2 or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation and death in vitro. J. Clin. Invest. 101:1998;1478-1487