Iron accumulation during cellular senescence

Annals of the New York Academy of Sciences

Volumn 1019, Issue , 2004, Pages 365-367

  Killilea, David W ^a,b   Wong, Stephanie L ^b   Cahaya, Hendry S ^b   Atamna, Hani ^a   Ames, Bruce N ^a,b  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^b University of California Berkeley   (United States)

Author keywords

Cellular senescence; Fibroblasts; Hydroxylamine; Iron; Oxidative stress

Indexed keywords

HYDROGEN PEROXIDE; HYDROXYLAMINE; IRON;

CELL ACTIVITY; CELL AGING; CELL CULTURE; CELL IMMORTALIZATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONFERENCE PAPER; FIBROBLAST; HUMAN; HUMAN CELL; OXIDATIVE STRESS; SUPPLEMENTATION;

EID: 3242666078     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1297.063     Document Type: Conference Paper

References (10)

1. WALTER, P.B, K.B. BECKMAN & B.N. AMES. 1999. The role of iron and mitochondria in aging. In Understanding the Process of Aging. E. Cadenas & L. Packer, Eds.: 203-227. Marcel Dekker. New York.
2. HALLIWELL, B. & J.M.C. GUTTERIDGE. 1999. Free radicals in biology and medicine. Oxford University Press. Oxford.
3. BECKMAN, K.B. & B.N. AMES. 1998. The free radical theory of aging matures. Physiol. Rev. 78: 547-581.
4. KILLILEA, D.W., H. ATAMNA, C. LIAO & B.N. AMES. 2003. Iron accumulation during cellular senescence in human fibroblasts in vitro. Antioxid. Redox Signal. 5: 507-516.
5. MASSIE, H.R., V.R. AIELLO & T.R. WILLIAMS. 1985. Iron accumulation during development and ageing of Drosophila. Mech. Ageing Dev. 29: 215-220.
6. MASSIE, H.R., V.R. AIELLO & T.R. WILLIAMS. 1993. Inhibition of iron absorption prolongs the life span of Drosophila. Mech. Ageing Dev. 67: 227-237.
7. ATAMNA, H., A. PALER-MARTINEZ & B.N. AMES. 2000. N-t-Butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts. J. Biol. Chem. 275: 6741-6748.
8. PANTOPOULOS, K. & M.W. HENTZE. 1995. Rapid responses to oxidative stress mediated by iron regulatory protein. EMBO J. 14: 2917-2924.
9. ATAMNA, H., D.W. KILLILEA, A.N. KILLILEA & B.N. AMES. 2002. Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging. Proc. Natl. Acad. Sci. USA 99: 14807-14812.
10. BRUNK, U.T. & A. TERMAN. 2002. Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic. Biol. Med. 33: 611-619.