Participation of cyclin D1 deregulation in TNP-470-mediated cytostatic effect: Involvement of senescence

Biochemical Pharmacology

Volumn 68, Issue 4, 2004, Pages 729-738

  Lien, Wen Huei ^a   Chen, Chi Kuan ^a   Lai, Ling Ya ^a   Chen, Ya Huey ^b   Wu, Ming Ping ^c,d   Wu, Li Wha ^a  

^a Institute of Molecular Medicine   (Taiwan)

^b Institute of Basic Medical Sciences   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d CHI MEI FOUNDATION HOSPITAL   (Taiwan)

Author keywords

basic fibroblast growth factors; bFGF; CDK; CDK inhibitor; CKI; cyclin dependent kinase; dimethyl sulfoxide; DMSO; FBS; fetal bovine serum; GAPDH; human umbilical vein endothelial cells; HUVECs; PCNA; proliferation cell nuclear antigen; Rb; retinoblastoma

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; BETA GALACTOSIDASE; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; FUMAGILLOL CHLOROACETYLCARBAMATE; MESSENGER RNA; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ARTICLE; CELL CYCLE G1 PHASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOSTASIS; DEREGULATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENESCENCE; SENSITIVITY ANALYSIS; STATISTICAL SIGNIFICANCE; UMBILICAL VEIN;

ANTIBIOTICS, ANTINEOPLASTIC; CDC2-CDC28 KINASES; CELL AGING; CELL CYCLE; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; CYCLOHEXANES; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; HUMANS; PROTO-ONCOGENE PROTEINS; SESQUITERPENES; SUBCELLULAR FRACTIONS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 3242663393     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.05.020     Document Type: Article

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