The extent and significance of telomere loss with age

Annals of the New York Academy of Sciences

Volumn 1019, Issue , 2004, Pages 265-268

  Baird, Duncan M ^a   Kipling, David ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Aging; Senescence; Telomere

Indexed keywords

CELL PROLIFERATION; CELL TYPE; CONFERENCE PAPER; CORRELATION ANALYSIS; EROSION; GENETIC HETEROGENEITY; HUMAN; IN SITU HYBRIDIZATION; IN VIVO STUDY; LIFESPAN; MEDICAL TECHNOLOGY; MOLECULAR DYNAMICS; NONHUMAN; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; SENESCENCE; TELOMERE;

SAMBUCUS NIGRA CANADENSIS;

EID: 3242663389     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1297.044     Document Type: Conference Paper

References (10)

1. HARLEY, C.B., A.B. FUTCHER & C.W. GREIDER. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460.
2. FARAGHER, R.G. & D. KIPLING. 1998. How might replicative senescence contribute to human ageing? Bioessays 20: 985-991.
3. TAKUBO, K., N. IZUMIYAMA-SHIMOMURA, N. HONMA, et al. 2002. Telomere lengths are characteristic in each human individual. Exp. Gerontol. 37: 523-531.
4. CHANG, E. & C.B. HARLEY. 1995. Telomere length and replicative aging in human vascular tissues. Proc. Natl. Acad. Sci. USA 92: 11190-11194.
5. CRISTOFALO, V.J., R.G. ALLEN, R.J. PIGNOLO, et al. 1998. Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation. Proc. Natl. Acad. Sci. USA 95: 10614-10619.
6. KOLQUIST, K.A., L.W. ELLISEN, C.M. COUNTER, et al. 1998. Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. Nat. Genet. 19: 182-186.
7. FRENCK, R.W., JR., E.H. BLACKBURN & K.M. SHANNON. 1998. The rate of telomere sequence loss in human leukocytes varies with age. Proc. Natl. Acad. Sci. USA 95: 5607-5510.
8. TAKUBO, K., K. NAKAMURA, N. IZUMIYAMA, et al. 2000. Telomere shortening with aging in human liver. J. Gerontol. A Biol. Sci. Med. Sci. 55: B533-B536.
9. O'SULLIVAN, J.N., M.P. BRONNER, T.A. BRENTNALL, et al. 2002. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat. Genet. 32: 280-284.
10. BAIRD, D.M., J. ROWSON, D. WYNFORD-THOMAS, et al. 2003. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat. Genet. 33: 203-207.