In heavy drinkers fatty acid ethyl esters in the serum are increased for 44 hr after ethanol consumption

Alcoholism: Clinical and Experimental Research

Volumn 28, Issue 7, 2004, Pages 1102-1106

  Borucki, Katrin ^a,c   Kunstmann, Steffen ^b   Dierkes, Jutta ^a   Westphal, Sabine ^a   Diekmann, Silvia ^a   Bogerts, Bernhard ^a   Luley, Claus ^a  

^a UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

^b Richter   (Germany)

^c Inst fur Klin Chem Pathobiochemie   (Germany)

Author keywords

Ethanol; Fatty Acid Ethyl Esters; Lipoproteins

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; FATTY ACID ESTER; GAMMA GLUTAMYLTRANSFERASE; LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; FATTY ACID BLOOD LEVEL; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GAS CHROMATOGRAPHY; HOSPITAL ADMISSION; HUMAN; HYPERTRIGLYCERIDEMIA; LIPID STORAGE; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; SERUM; TIME;

ADULT; ALCOHOL DRINKING; ALCOHOLIC INTOXICATION; FATTY ACIDS; FEMALE; HUMANS; LIPOPROTEINS; MALE; STATISTICS, NONPARAMETRIC; TIME FACTORS;

EID: 3242660940     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000130791.20186.4D     Document Type: Article

References (17)

1. Arndt T, Kropf J (2002) Alcohol abuse and carbohydrate-deficient transferrin analysis: are screening and confirmatory analysis required? Clin Chem 48:2072-2074.
2. Auwärter V, Sporkert F, Hartwig S, Pragst F, Vater H, Diefenbacher A (2001) Fatty acid ethyl esters in hair as markers of alcohol consumption. Segmental hair analysis of alcoholics, social drinkers, and teetotalers. Clin Chem 47:2114-2123.
3. Bernhardt TG, Cannistraro PA, Bird DA, Doyle KM, Laposata M (1996) Purification of fatty acid ethyl esters by solid phase extraction and high-performance liquid chromatography. J Chromatogr B Biomed Appl 675:189-196.
4. Bird DA, Kabakibi A, Laposata M (1997) The distribution of fatty acid ethyl esters among lipoproteins and albumin in human serum. Alcohol Clin Exp Res 21:602-605.
5. 13C NMR study. J Lipid Res 37:1449-1358.
6. Doyle KM, Bird DA, al-Salihi S, Hallaq Y, Cluette-Brown JE, Goss KA, Laposata M (1994) Fatty acid ethyl esters are present in human serum after ethanol ingestion J Lipid Res 35:428-437.
7. Doyle KM, Cluette-Brown JE, Dube DM, Bernhardt TG, Morse CR, Laposata M (1996) Fatty acid ethyl esters in the blood as markers for ethanol intake. JAMA 276:1152-1156.
8. Lange LG, Bergmann SR, Sobel BE (1981) Identification of fatty acid ethyl esters as products of rabbit myocardial ethanol metabolism. J Biol Chem 256:12968-12973.
9. Laposata EA, Lange LG (1986) Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science 31:497-499.
10. Laposata M (1999) Fatty acid ethyl esters: current facts and speculations (review). Prostaglandins Leukot Essent Fatty Acids 60:313-315.
11. Laposata M, Hasaba A, Best CA, Yoerger DM, McQuillan BM, Salem RO, Refaai MA, Soderberg BL (2002) Fatty acid ethyl esters: recent observations. Prostaglandins Leukot Essent Fatty Acids 67:193-196.
12. Lesch OM, Walter H, Freitag H, Heggli DE, Leitner A, Mader R, et al. (1996) Carbohydrate-deficient transferrin as a screening marker for drinking in a general hospital population. Alcohol 31:249-256.
13. Moore C, Jones J, Lewis D, Buchi K (2003) Prevalence of fatty acid ethyl esters in meconium specimens. Clin Chem 49:133-136.
14. Saghir M, Werner J, Laposata M (1997) Rapid in vivo hydrolysis of fatty acid ethyl esters, toxic nonoxidative ethanol metabolites. Am J Physiol 273:G184-G190.
15. Soderberg BL, Laposata M (2001) Fatty acid ethyl esters: markers of ethanol intake (review). Am Clin Lab 20:18-20.
16. Werner J, Laposata M, Fernandez-del Castillo C, Saghir M, Iozzo RV, Lewandrowski KB, Warshaw AL (1997) Pancreatic injury induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol. Gastroenterology 113:286-294.
17. Yersin B, Nicolet JF, Dercrey H, Burnier M, van Melle G, Pecoud A (1995) Screening for excessive alcohol drinking. Comparative value of carbohydrate-deficient transferrin, gamma- glutamyltransferase, and mean corpuscular volume, Arch Intern Med 25:1907-1911.