Prediction of milk/plasma drug concentration (M/P) ratio using support vector machine (SVM) method

Pharmaceutical Research

Volumn 23, Issue 1, 2006, Pages 41-48

  Zhao, Chunyan ^a   Zhang, Haixia ^a   Zhang, Xiaoyun ^a   Zhang, Ruisheng ^a   Luan, Feng ^a   Liu, Mancang ^a   Hu, Zhide ^a   Fan, Botao ^b  

^a LANZHOU UNIVERSITY   (China)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Bootstrapping validation; Linear discriminant analysis (LDA); Milk plasma drug concentration (M P) ratio; Molecular descriptors; Support vector machine (SVM)

Indexed keywords

ALPRAZOLAM; AMOXICILLIN; AMPICILLIN; CARBENICILLIN; CEFALEXIN; CEFOXITIN; CEFTRIAXONE; CLEMASTINE; ESTRADIOL; IBUPROFEN; METHOTREXATE; METHYLDOPA; NITRAZEPAM; NORETHISTERONE; NOSCAPINE; OXAZEPAM; PENICILLIN V; PHENYTOIN; PREDNISOLONE; QUINAPRIL; ROSARAMICIN; ROXITHROMYCIN; SULFAMETHOXAZOLE; SUPROFEN; TEMAZEPAM; TOLMETIN; UNINDEXED DRUG; VALPROIC ACID; WARFARIN; ZOLPIDEM;

ACCURACY; ALGORITHM; ANALYTIC METHOD; ARTICLE; CLASSIFICATION; DISCRIMINANT ANALYSIS; DRUG BLOOD LEVEL; DRUG MILK LEVEL; INTERMETHOD COMPARISON; MATHEMATICAL MODEL; NURSING CARE; PREDICTION; PRIORITY JOURNAL; STATISTICAL MODEL; SUPPORT VECTOR MACHINE; VALIDATION PROCESS;

ALGORITHMS; ARTIFICIAL INTELLIGENCE; FEMALE; HUMANS; LINEAR MODELS; MILK, HUMAN; MODELS, STATISTICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PLASMA; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP; TERMINOLOGY;

EID: 32244431564     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-005-8716-4     Document Type: Article

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