Regulation of RhoGAP specificity by phospholipids and prenylation

Methods in Enzymology

Volumn 406, Issue , 2006, Pages 104-117

  Ligeti, Erzsébet ^a   Settleman, Jeffrey ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PHOSPHOLIPID; PROTEIN P190; RHO FACTOR;

ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME SPECIFICITY; IN VITRO STUDY; PRENYLATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REGULATORY MECHANISM; STANDARDIZATION;

EID: 32144447411     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(06)06009-5     Document Type: Review

References (29)

1. Agnel M., Roder L., Vola C., and Griffin-Shea R. A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins Mol. Cell Biol. 12 1992 5111 5122
2. Barfod E.T., Zheng Y., Kuang W.J., Hart M.J., Evans T., Cerione R.A., and Ashkenazi A. Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain J. Biol. Chem. 268 1993 26059 26062
3. Bernards A. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila Biochim. Biophys. Acta 1603 2003 47 82
4. Bernards A., and Settleman J. GAP control: Regulating the regulators of small GTPases Trends Cell Biol. 14 2004 377 385
5. Bourne H.R., Sanders D.A., and McCormick F. The GTPase superfamily: A conserved switch for diverse cell functions Nature 348 1990 125 132
6. Bourne H.R., Sanders D.A., and McCormick F. The GTPase superfamily: Conserved structure and molecular mechanism Nature 349 1991 117 127
7. Brown M.T., Andrade J., Radhakrishna H., Donaldson J.G., Cooper J.A., and Randazzo P.A. ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src Mol. Cell Biol. 18 1998 7038 7051
8. Chuang T.H., Xu X., Kaartinen V., Heisterkamp N., Groffen J., and Bokoch G.M. Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family Proc. Natl. Acad. Sci. USA 92 1995 10282 10286
9. Di-Poi N., Faure J., Grizot S., Molnar G., Pick E., and Dagher M.C. Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex Biochemistry 40 2001 10014 10022
10. Diekmann D., Brill S., Garrett M.D., Totty N., Hsuan J., Monfries C., Hall C., Lim L., and Hall A. Bcr encodes a GTPase-activating protein for p21rac Nature 351 1991 400 402
11. Finlayson C.A., Chappell J., Leitner J.W., Goalstone M.L., Garrity M., Nawaz S., Ciaraldi T.P., and Draznin B. Enhanced insulin signaling via Shc in human breast cancer Metabolism 52 2003 1606 1611
12. Goalstone M.L., Leitner J.W., Berhanu P., Sharma P.M., Olefsky J.M., and Draznin B. Insulin signals to prenyltransferases via the Shc branch of intracellular signaling J. Biol. Chem. 276 2001 12805 12812
13. Hildebrand J.D., Taylor J.M., and Parsons J.T. An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase Mol. Cell Biol. 16 1996 3169 3178
14. Jullien-Flores V., Dorseuil O., Romero F., Letourneur F., Saragosti S., Berger R., Tavitian A., Gacon G., and Camonis J.H. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity J. Biol. Chem. 270 1995 22473 22477
15. Lancaster C.A., Taylor-Harris P.M., Self A.J., Brill S., van Erp H.E., and Hall A. Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases J. Biol. Chem. 269 1994 1137 1142
16. Ligeti E., Dagher M.C., Hernandez S.E., Koleske A.J., and Settleman J. Phospholipids can switch the GTPase substrate preference of a GTPase-activating protein J. Biol. Chem. 279 2004 5055 5058
17. Minoshima Y., Kawashima T., Hirose K., Tonozuka Y., Kawajiri A., Bao Y.C., Deng X., Tatsuka M., Narumiya S., May W.S. Jr., Nosaka T., Semba K., Inoue T., Satoh T., Inagaki M., and Kitamura T. Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis Dev. Cell 4 2003 549 560
18. Moskwa P., Paclet M.H., Dagher M.C., and Ligeti E. Autoinhibition of p50 Rho GTPase-activating protein (GAP) is released by prenylated small GTPases J. Biol. Chem. 280 2005 6716 6720
19. Park S.H., and Weinberg R.A. A putative effector of Ral has homology to Rho/Rac GTPase activating proteins Oncogene 11 1995 2349 2355
20. Prakash S.K., Paylor R., Jenna S., Lamarche-Vane N., Armstrong D.L., Xu B., Mancini M.A., and Zoghbi H.Y. Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA Hum. Mol. Genet. 9 2000 477 488
21. Ren X.R., Du Q.S., Huang Y.Z., Ao S.Z., Mei L., and Xiong W.C. Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein J. Cell Biol. 152 2001 971 984
22. Richnau N., and Aspenstrom P. Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1 J. Biol. Chem. 276 2001 35060 35070
23. Ridley A.J., Self A.J., Kasmi F., Paterson H.F., Hall A., Marshall C.J., and Ellis C. Rho family GTPase activating proteins p190, Bcr and RhoGAP show distinct specificities in vitro and in vivo EMBO J. 12 1993 5151 5160
24. Scheffzek K., Ahmadian M.R., Kabsch W., Wiesmülller L., Lautwein A., Schmitz F., and Wittinghofer A. The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants Science 277 1997 333 338
25. Self A.J., and Hall A. Purification of recombinant Rho/Rac/G25K from Escherichia coli Methods Enzymol. 256 1995 3 10
26. Shibata H., Oishi K., Yamagiwa A., Matsumoto M., Mukai H., and Ono Y. PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family J. Biochem. (Tokyo) 130 2001 23 31
27. Toure A., Dorseuil O., Morin L., Timmons P., Jegou B., Reibel L., and Gacon G. MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells J. Biol. Chem. 273 1998 6019 6023
28. Voncken J.W., van Schaick H., Kaartinen V., Deemer K., Coates T., Landing B., Pattengale P., Dorseuil O., Bokoch G.M., Groffen J., and Heisterkamp N. Increased neutrophil respiratory burst in Bcr-null mutants Cell 80 1995 719 728
29. Wong K., Ren X.R., Huang Y.Z., Xie Y., Liu G., Saito H., Tang H., Wen L., Brady-Kalnay S.M., Mei L., Wu J.Y., Xiong W.C., and Rao Y. Signal transduction in neuronal migration: Roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway Cell 107 2001 209 221