Discriminative stimulus effects of 5.6 mg/kg pregnanolone in DBA/2J and C57BL/6J inbred mice

Alcohol

Volumn 37, Issue 1, 2006, Pages 35-45

  Shannon, Erin E ^a   Purdy, Robert H ^b,c   Grant, Kathleen A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

C57BL 6J; DBA 2J; Drug discrimination; Neurosteroid; Pregnanolone

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; ELTANOLONE; MIDAZOLAM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROACTIVE STEROID; SEROTONIN 3 AGONIST; STEROID; UNCLASSIFIED DRUG; ZOLPIDEM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DISCRIMINATION; INBRED STRAIN; MALE; MOUSE; MOUSE STRAIN; NEUROMODULATION; NONHUMAN; STIMULUS RESPONSE;

ANIMALS; BARBITURATES; BENZODIAZEPINES; DISCRIMINATION (PSYCHOLOGY); DIZOCILPINE MALEATE; ETHANOL; GABA AGENTS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; PIPERIDINES; PREGNANOLONE; RECEPTORS, N-METHYL-D-ASPARTATE; SEROTONIN AGONISTS;

ANIMALIA;

EID: 32044469835     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.alcohol.2005.11.001     Document Type: Article

References (22)

1. N.A. Ator, K.A. Grant, R.H. Purdy, S.M. Paul, and R.R. Griffiths Drug discrimination analysis of endogenous neuroactive steroids in rats Eur J Pharmacol 241 1993 237 243
2. P. Bienkowski, and W. Kostowski Discriminative stimulus properties of ethanol in the rat: effects of neurosteroids and picrotoxin Brain Res 753 1997 348 352
3. C.A. Bowen, G.J. Gatto, and K.A. Grant Assessment of the multiple discriminative stimulus effects of ethanol using an ethanol-pentobarbital-water discrimination in rats Behav Pharmacol 8 1997 339 352
4. C.A. Bowen, and K.A. Grant Increased specificity of ethanol's discriminative stimulus effects in an ethanol-pentobarbital-water discrimination in rats Drug Alcohol Depend 55 1999 13 24
5. S.R. Engel, R.H. Purdy, and K.A. Grant Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone J Pharmacol Exp Ther 297 2001 489 495
6. A receptor Eur J Pharmacol Mol Pharmacol Sect 246 1993 283 287
7. K.A. Grant, and S.R. Engel Neurosteroids and behavior G. Biggio R.H. Purdy Neurosteroids and Brain Function 2001 Academic Press San Diego, CA 321 342
8. S.G. Holtzman Discriminative stimulus effects of drugs: relationship to potential for abuse M.W. Adler A. Cowan Modern Methods in Pharmacology, Testing and Evaluation of Drugs of Abuse 1990 Wiley-Liss New York 193 210
9. A receptor subunit levels in association with increased anxiety Brain Res 910 2001 55 66
10. W. Koek, M.S. Kleven, and F.C. Colpaert Effects of the NMDA antagonist, dizocilipine, in various drug discriminations: characterization of intermediate levels of drug lever selection Behav Pharmacol 6 1995 590 600
11. A receptor function Trends Pharmacol Sci 16 1995 295 303
12. A.L. Morrow, M.J. VanDoren, S.N. Penland, and D.B. Matthews The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence Brain Res Brain Rev 37 2001 98 109
13. M. Park-Chung, F.-S. Wu, and D.H. Farb 3α-Hydroxy-5β-pregnan- 20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons Mol Pharmacol 46 1994 146 150
14. A receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys J Pharmacol Exp Ther 313 2005 658 667
15. A receptor complex Neurosci Lett 135 1992 273 275
16. A receptors Neuropharmacology 32 1993 59 63
17. A receptor α5-subunit creates novel type II benzodiazepine receptor pharmacology J Neurochem 54 1990 1802 1804
18. A-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes J Med Chem 33 1990 1572 1581
19. E.E. Shannon, P. Porcu, R.H. Purdy, and K.A. Grant Characterization of the discriminative stimulus effects of neuroactive steroid pregnanolone in DBA/2J and C57BL/6J inbred mice J Pharmacol Exp Ther 314 2005 675 685
20. K.L. Shelton, and K.A. Grant Discriminative stimulus effects of ethanol in C57BL/6J and DBA/2J inbred mice Alcohol Clin Exp Res 26 2002 747 757
21. M.J. VanDoren, D.B. Matthews, G.C. Janis, A.C. Grobin, L.L. Devaud, and A.L. Morrow Neuroactive steroid 3α-hydroxy-5α-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol J Neurosci 20 2000 1982 1989
22. K.E. Vanover Discriminative stimulus effects of the endogenous neuroactive steroid pregnanolone Eur J Pharmacol 327 1997 97 101