Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 1, 2004, Pages 240-246

  Wu, Hsiang En ^a   Thompson, Jonathan ^a   Sun, Han Sen ^a   Leitermann, Randy J ^a   Fujimoto, James M ^a   Tseng, Leon F ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHOXYNALTREXONE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; BETA ENDORPHIN; BETA ENDORPHIN ANTIBODY; BINALTORPHIMINE; CHOLECYSTOKININ; CHOLECYSTOKININ ANTIBODY; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; DELTORPHIN; DELTORPHIN II; DIZOCILPINE; DIZOCILPINE MALEATE; DYNORPHIN A; DYNORPHIN A ANTIBODY; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; KAPPA OPIATE RECEPTOR; LEUCINE ENKEPHALIN; LEUCINE ENKEPHALIN ANTIBODY; METENKEPHALIN; METENKEPHALIN ANTIBODY; MORPHINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALOXONE; NALTRINDOLE; SUBSTANCE P; SUBSTANCE P ANTIBODY; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANALGESIA; ARTICLE; ATTENUATION; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; LOW DRUG DOSE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; SPINAL CORD; TAIL FLICK TEST;

ANALGESIA; ANIMALS; BETA-ENDORPHIN; DIZOCILPINE MALEATE; DRUG INTERACTIONS; DRUG TOLERANCE; DYNORPHINS; ENKEPHALINS; MALE; MICE; MORPHINE; NALOXONE; NALTREXONE; OLIGOPEPTIDES; PAIN; PAIN MEASUREMENT; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; SPINAL CORD; SUBSTANCE P;

EID: 3042690201     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.065334     Document Type: Article

References (33)

1. Aksu F, Holmes BB, and Fujimoto JM (1993) Opioid antagonist: indirect antagonism of morphine analgesia by spinal dynorphin A. Pharmacol Biochem Behav 45:409-418.
2. Brown GP, Yang K, King MA, Rossi GC, leventhal L, Chang A, and Pasternak GW (1997) 3-Methoxynaltrexone, a selective heroin/morphine-6β-glucuronide antagonist. FEBS Lett 412:35-38.
3. Crain SM and Shen K (1990) Opioids can evoke direct receptor-mediated excitatory effects on sensory neurons. Trends Pharmacol Sci 11:77-81.
4. Crain SM and Shen K (1995) Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinocicetpive potency and attenuating tolerance/dependence during chronic treatment. Proc Natl Acad Sci USA 92:10540-10544.
5. Crain SM and Shen K (2000) Antagonists of excitatory opioid receptor functions enhance morphine's analgesic potency and attenuate opioid tolerance/dependence liability. Pain 84:121-131.
6. D'Amour FE and Smith DL (1941) A method for determining loss of pain sensation. J Pharmacol Exp Ther 72:74-79.
7. Eisenach JC (2000) Preemptive hyperalgesia, not analgesia? Anesthesiology 92:308-309.
8. Fujimoto JM, Arts KS, Rady JJ, and Tseng LF (1990) Spinal dynorphin A (1-17): possible mediator of antianalgesic action. Neuropharmacology 29:609-617.
9. Fujimoto JM and Rady JJ (1989) Intracerebroventricular physostigmine-induced analgesia: enhancement by naloxone, β-funaltrexamine and nor-binaltorphimine and antagonism by dynorphin A(1-17). J Pharmacol Exp Ther 251:1045-1052.
10. Holmes BB and Fujimoto JM (1993) Inhibiting a spinal dynorphin A component enhances intrathecal morphine antinociception in mice. Anesth Analg 77:1166-1173.
11. Hylden JL and Wilcox GL (1980) Intrathecal morphine in mice: a new technique. Eur J Pharmacol 167:313-316.
12. Iijima I, Minamikawa JI, Jacobsen AE, Brossi A, and Rice KE (1978) Studies in the (+)-morphine series-5. Synthesis and biological properties of (+)-naloxone. J Med Chem 21:398-400.
13. Leitermann RJ, Terashvili M, Mizoguchi H, Chen F, Clithero A, and Tseng LF (2003) Release of immunoreactive dynorphin A(1-17) from the spinal cord by intrathecal perfusion of endomorphin-2, but not endomorphin-1 in anesthetized rats. Soc Neurosci Abstr 33:908-12.
14. Malmberg AB and Yaksh TL (1992) hyperalgesia mediated by spinal glutamate or SP receptor blocked by spinal cyclooxygenase inhibition. Science (Wash DC) 257:1276-1279.
15. Mao J, Price DD, and Mayer DJ (1995) Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interaction. Pain 62:259-274.
16. Millan MJ (1999) The induction of pain: an integrative review. Prog Neurobiol 57:1-164.
17. Mizoguchi H, Narita M, Nagase H, and Tseng LF (1995) Antisense oligodeoxynucleotide to a δ-opioid receptor blocks the antinociception induced by cold water swimming. Regul Pept 59:255-259.
18. Ohsawa M, Mizoguchi H, Narita M, Nagase H, Kampine JP, and Tseng LF (2001) Different antinociception induced by spinally administered endomorphin-1 and endomorphin-2 in the mouse. J Pharmacol Exp Ther 298:592-597.
19. Pan ZZ, Tershner SA, and Fields HL (1997) Cellular mechanism for anti-analgesic action of agonists of the κ-opioid receptor. Nature (Lond) 389:382-385.
20. Rady JJ, Holmes BB, and Fujimoto JM (1998) Supraspinal flumazenil inhibits the antianalgesic action of spinal dynorphin A. Pharmacol Biochem Behav 60:1-10.
21. Rady JJ, Holmes BB, Tseng LF, and Fujimoto JM (2001) Inverse agonist action of Leu-enkephalin at δ2-opioid receptors mediates spinal antianalgesia. J Pharmacol Exp Ther 297:582-589.
22. Sakurada S, Hayashi T, Yuhki M, Fujimura T, Murayama K, Yonezawa A, Sakurada C, Takeshita M, Zadina JE, Kastin AJ, et al. (2000) Different antagonism of endomorphin-1 and endomorphin-2 spinal antinociception by naloxonazine and 3-methoxynaltrexone. Brain Res 881:1-8.
23. Salter MW and Henry JL (1991) Responses of functionally identified neurons in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin. Neuroscience 4:601-610.
24. Suh HH and Tseng LF (1988) Intrathecal β-funaltrexamine antagonizes intracerebroventricular β-endorphin- but not morphine-induced analgesia in mice. J Pharmacol Exp Ther 245:587-593.
25. Tseng LF and Collin KA (1993) Spinal involvement of both dynorphin A and metenkephalin in the antinociception induced by intracerebroventricularly administered bremazocine but not morphine in the mouse. J Pharmacol Exp Ther 266:1430-1438.
26. 5]enkephalin and cholecystokinin from the spinal cord by β-endorphin administered intraventricularly in the pentobarbital- anesthetized rat. Eur J Pharmacol 215:309-312.
27. Tseng LF, Narita M, Mizoguchi H, Kawai K, Mizusuna A, Kamei J, Suzuki T, and Nagase H (1997) Delta-1 opioid receptor-mediated antinociceptive properties of a nonpeptidic delta opioid receptor agonist, (-) TAN-67, in the mouse spinal cord. J Pharmacol Exp Ther 280:600-605.
28. Vanderah TW, Laughlin T, Lashbrook JM, Nichols ML, Wilcox GL, Ossipov MH, Malan TP, and Porreca F (1996) Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone. Pain 68:275-281.
29. Vanderah TW, Ossipov MH, Lai J, Malan TP, and Porreca F (2001) Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin. Pain 92:5-9.
30. Wang FS, Rady JJ, and Fujimoto JM (1994) Elimination of the antianalgesic action of dynorphin A (1-17) by spinal transsection in barbital anesthetized mice. J Pharmacol Exp Ther 268:873-880.
31. Wu H, Hung K, Mizoguchi H, Nagase H, and Tseng LF (2002) Roles of endogenous opioid peptides in modulation of nocifensive response to formalin. J Pharmacol Exp Ther 300:647-654.
32. Wu H, Sun H, Darpolar M, Leitermann JR, Kampine JP, and Tseng LF (2003) Dynorphinergic mechanism mediating endomorphin-2-induced anti-analgesia in the mouse spinal cord. J Pharmacol Exp Ther 307:1135-1141.
33. Xu JY and Tseng LF (1997) [Met]enkephalin in the spinal cord is involved in the antinociception induced by intracerebroventricularly-administered etorphine in the mouse. Neuroscience 80:579-585.