Derivation of adipocytes from human embryonic stem cells

Stem Cells and Development

Volumn 14, Issue 6, 2005, Pages 671-675

  Xiong, Chen ^a,d   Xie, Chang Qing ^a   Zhang, Li ^a   Zhang, Jifeng ^a   Xu, Kefeng ^a   Fu, Mingui ^b   Thompson, Winston E ^a   Yang, Li Jun ^c   Chen, Yuqing E ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; FATTY ACID BINDING PROTEIN; LEPTIN; MOLECULAR MARKER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; ROSIGLITAZONE;

ADIPOCYTE; ADIPOGENESIS; ARTICLE; CELL DIFFERENTIATION; CELL SPECIFICITY; CONTROLLED STUDY; CYTOPLASM; EMBRYO CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID STORAGE; OBESITY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RISK FACTOR; STEM CELL;

ADIPOCYTES; ADIPOGENESIS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; CULTURE MEDIA; EMBRYO; EMBRYONIC DEVELOPMENT; HUMANS; STEM CELLS; THIAZOLIDINEDIONES;

EID: 32044446032     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2005.14.671     Document Type: Article

References (19)

1. Thomson JA, J Itskovitz-Eldor, SS Shapiro, MA Waknitz, JJ Swiergiel, VS Marshall and JM Jones. (1998). Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147.
2. Reubinoff BE, MF Pera, CY Fong, A Trounson and A Bongso. (2000). Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nature Biotechnol 18:399-404.
3. Reubinoff BE, P Itsykson, T Turetsky, MF Pera, E Reinhartz, A Itzik and T Ben-Hur. (2001). Neural progenitors from human embryonic stem cells. Nature Biotechnol 19:1134-1140.
4. Kehat I, D Kenyagin-Karsenti, M Snir, et al. (2001). Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest 108:407-414.
5. Kaufman DS, ET Hanson, RL Lewis, R Auerbach and JA Thomson. (2001). Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc Natl Acad Sci USA 98:10716-10721.
6. Levenberg S, JS Golub, M Amit, J Itskovitz-Eldor and R Langer. (2002). Endothelial cells derived from human embryonic stem cells. Proc Natl Acad Sci USA 99:4391-4396.
7. Segev H, B Fishman, A Ziskind, M Shulman and J Itskovitz-Eldor. (2004). Differentiation of Human Embryonic Stem Cells into Insulin-Producing Clusters. Stem Cells 22:265-274.
8. Ahima RS and JS Flier. (2000). Adipose tissue as an endocrine organ. Trends Endocrinol Metab 11:327-332.
9. Camp HS, D Ren and T Leff. (2002). Adipogenesis and fat-cell function in obesity and diabetes. Trends Mol Med 8:442-447.
10. Bernlohr DA, MA Bolanowski, TJ Kelly Jr and MD Lane. (1985). Evidence for an increase in transcription of specific mRNAs during differentiation of 3T3-L1 preadipocytes. J Biol Chem. 260:5563-5567.
11. Kim YC, FE Gomez, BG Fox and JM Ntambi. (2000). Differential regulation of the stearoyl-CoA desaturase genes by thiazolidinediones in 3T3-L1 adipocytes. J Lipid Res 41:1310-1316.
12. Xiong C, DQ Tang, CQ Xie, L Zhang, KF Xu, WE Thompson, W Chou, GH Gibbons, LJ Chang, LJ Yang and YE Chen. (2005). Genetic engineering of human embryonic stem cells with lentiviral vectors. Stem Cell Dev 14(4):367-377.
13. Dani C, AG Smith, S Dessolin, P Leroy, L Staccini, P Villageois, C Darimont and G Ailhaud. (1997). Differentiation of embryonic stem cells into adipocytes in vitro. J Cell Sci 110:1279-1285.
14. Zhang J, M Fu, T Cui, C Xiong, K Xu, W Zhong, Y Xiao, D Floyd, J Liang, E Li, Q Song and YE Chen. (2004). Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity. Proc Natl Acad Sci USA 101:10703-10708.
15. Donnelly R and KR Davis. (2000). Type 2 diabetes and atherosclerosis. Diabetes Obes Metab 2(Suppl 1):S21-S30.
16. Allison DB, KR Fontaine, JE Manson, J Stevens and TB VanItallie. (1999). Annual deaths attributable to obesity in the United States. J Am Med Assn 282:1530-1538.
17. Rosen ED and BM Spiegelman. (2000). Molecular regulation of adipogenesis. Annu Rev Cell Dev 16:145-171.
18. Rosen ED and BM Spiegelman. (2000). Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 16:145-171.
19. Kliewer SA, K Umesono, DJ Noonan, RA Heyman and RM Evans. (1992). Convergence of 9-cis retinoic acid and peroxisome proliferator signaling pathways through heterodimer formation of their receptors. Nature 358:771-774.