메뉴 건너뛰기




Volumn 46, Issue 6, 2005, Pages 1236-1242

The prothrombotic paradox of hypertension: Role of the renin-angiotensin and kallikrein-kinin systems

Author keywords

Blood pressure; Kallikrein kinin systems; Renin angiotensin system

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ATENOLOL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRBESARTAN; KALLIKREIN; KININ; LOSARTAN; PERINDOPRIL; RAMIPRIL; RENIN; THROMBOPLASTIN;

EID: 31944445388     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000193538.20705.23     Document Type: Short Survey
Times cited : (91)

References (63)
  • 1
    • 0033755029 scopus 로고    scopus 로고
    • Hypertension and the prothrombotic state
    • Lip GY. Hypertension and the prothrombotic state. J Hum Hypertens. 2000;14:687-690.
    • (2000) J Hum Hypertens , vol.14 , pp. 687-690
    • Lip, G.Y.1
  • 2
    • 0037318286 scopus 로고    scopus 로고
    • Hypertension, platelets, and the endothelium: The "thrombotic paradox" of hypertension (or "Birmingham paradox") revisited
    • Lip GY. Hypertension, platelets, and the endothelium: the "thrombotic paradox" of hypertension (or "Birmingham paradox") revisited. Hypertension. 2003;41:199-200.
    • (2003) Hypertension , vol.41 , pp. 199-200
    • Lip, G.Y.1
  • 3
    • 0030463369 scopus 로고    scopus 로고
    • Endothelial function in different organs
    • Bassenge E. Endothelial function in different organs. Prog Cardiovasc Dis. 1996;39:209-228.
    • (1996) Prog Cardiovasc Dis , vol.39 , pp. 209-228
    • Bassenge, E.1
  • 6
    • 0023154874 scopus 로고
    • Cell biology of endothelial cells
    • Jaffe EA. Cell biology of endothelial cells. Hum Pathol. 1987;18:234-239.
    • (1987) Hum Pathol , vol.18 , pp. 234-239
    • Jaffe, E.A.1
  • 7
    • 0031727620 scopus 로고    scopus 로고
    • Some thoughts about localization and expression of tissue factor
    • Nemerson Y, Giesen PL. Some thoughts about localization and expression of tissue factor. Blood Coagul Fibrinolysis. 1998;9(suppl 1):S45-S47.
    • (1998) Blood Coagul Fibrinolysis , vol.9 , Issue.1 SUPPL.
    • Nemerson, Y.1    Giesen, P.L.2
  • 11
    • 0344630172 scopus 로고    scopus 로고
    • The blood coagulation system as a molecular machine
    • Spronk HM, Govers-Riemslag JW, ten Cate H. The blood coagulation system as a molecular machine. BioEssays. 2003;25:1220-1228.
    • (2003) BioEssays , vol.25 , pp. 1220-1228
    • Spronk, H.M.1    Govers-Riemslag, J.W.2    Ten Cate, H.3
  • 12
    • 0024327242 scopus 로고
    • Interaction of type 1 plasminogen activator inhibitor with the enzymes of the contact activation system
    • Berrettini M, Schleef RR, Espana F, Loskutoff DJ, Griffin JH. Interaction of type 1 plasminogen activator inhibitor with the enzymes of the contact activation system. J Biol Chem. 1989;264:11738-11743.
    • (1989) J Biol Chem , vol.264 , pp. 11738-11743
    • Berrettini, M.1    Schleef, R.R.2    Espana, F.3    Loskutoff, D.J.4    Griffin, J.H.5
  • 14
    • 0036154210 scopus 로고    scopus 로고
    • Angiotensin and vascular fibrinolytic balance
    • Vaughan DE. Angiotensin and vascular fibrinolytic balance. Am J Hypertens. 2002;15:3S-8S.
    • (2002) Am J Hypertens , vol.15
    • Vaughan, D.E.1
  • 16
    • 0028912882 scopus 로고
    • Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis
    • Vaughan DE, Lazos SA, Tong K. Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis. J Clin Invest. 1995;95:995-1001.
    • (1995) J Clin Invest , vol.95 , pp. 995-1001
    • Vaughan, D.E.1    Lazos, S.A.2    Tong, K.3
  • 19
    • 0033064882 scopus 로고    scopus 로고
    • Secondary endothelial dysfunction: Hypertension and heart failure
    • Boulanger CM. Secondary endothelial dysfunction: hypertension and heart failure. J Mol Cell Cardiol. 1999;31:39-49.
    • (1999) J Mol Cell Cardiol , vol.31 , pp. 39-49
    • Boulanger, C.M.1
  • 21
    • 0034808298 scopus 로고    scopus 로고
    • Clinically important factors influencing endothelial function
    • Vapaatalo H, Mervaala E. Clinically important factors influencing endothelial function. Med Sci Monit. 2001;7:1075-1085.
    • (2001) Med Sci Monit , vol.7 , pp. 1075-1085
    • Vapaatalo, H.1    Mervaala, E.2
  • 22
    • 0036120563 scopus 로고    scopus 로고
    • The plasma kallikrein-kinin system counterbalances the renin-angiotensin system
    • Schmaier AH. The plasma kallikrein-kinin system counterbalances the renin-angiotensin system. J Clin Invest. 2002;109:1007-1009.
    • (2002) J Clin Invest , vol.109 , pp. 1007-1009
    • Schmaier, A.H.1
  • 23
    • 18244391184 scopus 로고    scopus 로고
    • Angiotensin-(1-7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats
    • Walters PE, Gaspari TA, Widdop RE. Angiotensin-(1-7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats. Hypertension. 2005;45:960-966.
    • (2005) Hypertension , vol.45 , pp. 960-966
    • Walters, P.E.1    Gaspari, T.A.2    Widdop, R.E.3
  • 24
    • 0029957146 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor mRNA expression in the developing cardiopulmonary system of the rat
    • Shanmugam S, Corvol P, Gasc JM. Angiotensin II type 2 receptor mRNA expression in the developing cardiopulmonary system of the rat. Hypertension. 1996;28:91-97.
    • (1996) Hypertension , vol.28 , pp. 91-97
    • Shanmugam, S.1    Corvol, P.2    Gasc, J.M.3
  • 25
    • 0030807119 scopus 로고    scopus 로고
    • Angiotensin II increases plasminogen activator inhibitor-1 and tissue factor mRNA expression without changing that of tissue type plasminogen activator or tissue factor pathway inhibitor in cultured rat aortic endothelial cells
    • Nishimura H, Tsuji H, Masuda H, Nakagawa K, Nakahara Y, Kitamura H, Kasahara T, Sugano T, Yoshizumi M, Sawada S, Nakagawa M. Angiotensin II increases plasminogen activator inhibitor-1 and tissue factor mRNA expression without changing that of tissue type plasminogen activator or tissue factor pathway inhibitor in cultured rat aortic endothelial cells. Thromb Haemost. 1997;77:1189-1195.
    • (1997) Thromb Haemost , vol.77 , pp. 1189-1195
    • Nishimura, H.1    Tsuji, H.2    Masuda, H.3    Nakagawa, K.4    Nakahara, Y.5    Kitamura, H.6    Kasahara, T.7    Sugano, T.8    Yoshizumi, M.9    Sawada, S.10    Nakagawa, M.11
  • 28
    • 0036100587 scopus 로고    scopus 로고
    • Angiotensin II and IV stimulate expression and release of plasminogen activator inhibitor-1 in cultured human coronary artery endothelial cells
    • Mehta JL, Li DY, Yang H, Raizada MK. Angiotensin II and IV stimulate expression and release of plasminogen activator inhibitor-1 in cultured human coronary artery endothelial cells. J Cardiovasc Pharmacol. 2002;39:789-794.
    • (2002) J Cardiovasc Pharmacol , vol.39 , pp. 789-794
    • Mehta, J.L.1    Li, D.Y.2    Yang, H.3    Raizada, M.K.4
  • 29
    • 0032868908 scopus 로고    scopus 로고
    • Comparative effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on plasma fibrinolytic balance in humans
    • Brown NJ, Agirbasli M, Vaughan DE. Comparative effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on plasma fibrinolytic balance in humans. Hypertension. 1999;34:285-290.
    • (1999) Hypertension , vol.34 , pp. 285-290
    • Brown, N.J.1    Agirbasli, M.2    Vaughan, D.E.3
  • 30
    • 0036899135 scopus 로고    scopus 로고
    • ACE inhibition versus angiotensin type 1 receptor antagonism: Differential effects on PAI-1 over time
    • Brown NJ, Kumar S, Painter CA, Vaughan DE. ACE inhibition versus angiotensin type 1 receptor antagonism: differential effects on PAI-1 over time. Hypertension. 2002;40:859-865.
    • (2002) Hypertension , vol.40 , pp. 859-865
    • Brown, N.J.1    Kumar, S.2    Painter, C.A.3    Vaughan, D.E.4
  • 31
    • 0028802190 scopus 로고
    • Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV
    • Kerins DM, Hao Q, Vaughan DE. Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV. J Clin Invest. 1995;96:2515-2520.
    • (1995) J Clin Invest , vol.96 , pp. 2515-2520
    • Kerins, D.M.1    Hao, Q.2    Vaughan, D.E.3
  • 32
    • 0036892390 scopus 로고    scopus 로고
    • Activation of the bradykinin-forming cascade on endothelial cells: A role for heat shock protein 90
    • Joseph K, Tholanikunnel BG, Kaplan AP. Activation of the bradykinin-forming cascade on endothelial cells: a role for heat shock protein 90. Int Immunopharmacol. 2002;2:1851-1859.
    • (2002) Int Immunopharmacol , vol.2 , pp. 1851-1859
    • Joseph, K.1    Tholanikunnel, B.G.2    Kaplan, A.P.3
  • 33
    • 0037125229 scopus 로고    scopus 로고
    • Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator
    • Moreira CR, Schmaier AH, Mahdi F, da Motta G, Nader HB, Shariat-Madar Z. Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator. FEBS Lett. 2002;523:167-170.
    • (2002) FEBS Lett , vol.523 , pp. 167-170
    • Moreira, C.R.1    Schmaier, A.H.2    Mahdi, F.3    Da Motta, G.4    Nader, H.B.5    Shariat-Madar, Z.6
  • 34
    • 0037636471 scopus 로고    scopus 로고
    • The kallikrein-kinin and the renin-angiotensin systems have a multilayered interaction
    • Schmaier AH. The kallikrein-kinin and the renin-angiotensin systems have a multilayered interaction. Am J Physiol Regul Integr Comp Physiol. 2003;285:R1-R13.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285
    • Schmaier, A.H.1
  • 35
    • 0037417843 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin
    • Pretorius M, Rosenbaum D, Vaughan DE, Brown NJ. Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin. Circulation. 2003;107:579-585.
    • (2003) Circulation , vol.107 , pp. 579-585
    • Pretorius, M.1    Rosenbaum, D.2    Vaughan, D.E.3    Brown, N.J.4
  • 36
    • 0029070675 scopus 로고
    • Studies on the acute release of tissue-type plasminogen activator from human endothelial cells in vitro and in rats in vivo: Evidence for a dynamic storage pool
    • Van den Eijnden-Schrauwen Y, Kooistra T, de Vries RE, Emeis JJ. Studies on the acute release of tissue-type plasminogen activator from human endothelial cells in vitro and in rats in vivo: evidence for a dynamic storage pool. Blood. 1995;85:3510-3517.
    • (1995) Blood , vol.85 , pp. 3510-3517
    • Van Den Eijnden-Schrauwen, Y.1    Kooistra, T.2    De Vries, R.E.3    Emeis, J.J.4
  • 37
    • 0025874052 scopus 로고
    • Factor XI activation in a revised model of blood coagulation
    • Gailani D, Braze GJ Jr. Factor XI activation in a revised model of blood coagulation. Science. 1991;253:909-912.
    • (1991) Science , vol.253 , pp. 909-912
    • Gailani, D.1    Braze Jr., G.J.2
  • 38
    • 0031964489 scopus 로고    scopus 로고
    • Levels of activated FXII in survivors of myocardial infarction - Association with circulating risk factors and extent of coronary artery disease
    • Kohler HP, Carter AM, Stickland MH, Grant PJ. Levels of activated FXII in survivors of myocardial infarction - association with circulating risk factors and extent of coronary artery disease. Thromb Haemost. 1998;79:14-18.
    • (1998) Thromb Haemost , vol.79 , pp. 14-18
    • Kohler, H.P.1    Carter, A.M.2    Stickland, M.H.3    Grant, P.J.4
  • 40
    • 0842325878 scopus 로고    scopus 로고
    • Activated factor 12 (FXIIa) predicts recurrent coronary events after an acute myocardial infarction
    • Grundt H, Nilsen DW, Hetland O, Valente E, Fagertun HE. Activated factor 12 (FXIIa) predicts recurrent coronary events after an acute myocardial infarction. Am Heart J. 2004;147:260-266.
    • (2004) Am Heart J , vol.147 , pp. 260-266
    • Grundt, H.1    Nilsen, D.W.2    Hetland, O.3    Valente, E.4    Fagertun, H.E.5
  • 41
    • 0029029679 scopus 로고
    • Alterations of coagulation and fibrinolytic and kallikrein-kinin systems in the acute and postacute phases in patients with unstable angina pectoris
    • Hoffmeister HM, Jur M, Wendel HP, Heller W, Seipel L. Alterations of coagulation and fibrinolytic and kallikrein-kinin systems in the acute and postacute phases in patients with unstable angina pectoris. Circulation. 1995;91:2520-2527.
    • (1995) Circulation , vol.91 , pp. 2520-2527
    • Hoffmeister, H.M.1    Jur, M.2    Wendel, H.P.3    Heller, W.4    Seipel, L.5
  • 42
    • 0030980764 scopus 로고    scopus 로고
    • Factor XIIa activation of plasminogen is enhanced by contact activating surfaces and Zn2+
    • Schousboe I. Factor XIIa activation of plasminogen is enhanced by contact activating surfaces and Zn2+. Blood Coagul Fibrinolysis. 1997;8:97-104.
    • (1997) Blood Coagul Fibrinolysis , vol.8 , pp. 97-104
    • Schousboe, I.1
  • 44
    • 0032753040 scopus 로고    scopus 로고
    • Effects of angiotensin converting enzyme and angiotensin II receptor inhibition on impaired fibrinolysis in systemic hypertension
    • Erdem Y, Usalan C, Haznedaroglu IC, Altun B, Arici M, Yasavul U, Turgan C, Caglar S. Effects of angiotensin converting enzyme and angiotensin II receptor inhibition on impaired fibrinolysis in systemic hypertension. Am J Hypertens. 1999;12:1071-1076.
    • (1999) Am J Hypertens , vol.12 , pp. 1071-1076
    • Erdem, Y.1    Usalan, C.2    Haznedaroglu, I.C.3    Altun, B.4    Arici, M.5    Yasavul, U.6    Turgan, C.7    Caglar, S.8
  • 45
    • 0029814343 scopus 로고    scopus 로고
    • Bradykinin and its metabolite, Arg-Pro-Pro-Gly-Phe, are selective inhibitors of alpha-thrombin-induced platelet activation
    • Hasan AA, Amenta S, Schmaier AH. Bradykinin and its metabolite, Arg-Pro-Pro-Gly-Phe, are selective inhibitors of alpha-thrombin-induced platelet activation. Circulation. 1996;94:517-528.
    • (1996) Circulation , vol.94 , pp. 517-528
    • Hasan, A.A.1    Amenta, S.2    Schmaier, A.H.3
  • 46
    • 11144291216 scopus 로고    scopus 로고
    • Mapping the interaction of bradykinin 1-5 with the exodomain of human protease activated receptor 4
    • Nieman MT, Pagan-Ramos E, Warnock M, Krijanovski Y, Hasan AA, Schmaier AH. Mapping the interaction of bradykinin 1-5 with the exodomain of human protease activated receptor 4. FEBS Lett. 2005;579:25-29.
    • (2005) FEBS Lett , vol.579 , pp. 25-29
    • Nieman, M.T.1    Pagan-Ramos, E.2    Warnock, M.3    Krijanovski, Y.4    Hasan, A.A.5    Schmaier, A.H.6
  • 47
    • 0018146185 scopus 로고
    • Human urinary kallikrein converts inactive to active renin and is a possible physiological activator of renin
    • Sealey JE, Atlas SA, Laragh JH, Oza NB, Ryan JW. Human urinary kallikrein converts inactive to active renin and is a possible physiological activator of renin. Nature. 1978;275:144-145.
    • (1978) Nature , vol.275 , pp. 144-145
    • Sealey, J.E.1    Atlas, S.A.2    Laragh, J.H.3    Oza, N.B.4    Ryan, J.W.5
  • 48
    • 0018236560 scopus 로고
    • Linking the kallikrein and renin systems via activation of inactive renin: New data and a hypothesis
    • Sealey JE, Atlas SA, Laragh JH. Linking the kallikrein and renin systems via activation of inactive renin: new data and a hypothesis. Am J Med. 1978;65:994-1000.
    • (1978) Am J Med , vol.65 , pp. 994-1000
    • Sealey, J.E.1    Atlas, S.A.2    Laragh, J.H.3
  • 49
    • 0031028895 scopus 로고    scopus 로고
    • Additive effects of losartan and enalapril on blood pressure and plasma active renin
    • Azizi M, Guyene TT, Chatellier G, Wargon M, Menard J. Additive effects of losartan and enalapril on blood pressure and plasma active renin. Hypertension. 1997;29:634-640.
    • (1997) Hypertension , vol.29 , pp. 634-640
    • Azizi, M.1    Guyene, T.T.2    Chatellier, G.3    Wargon, M.4    Menard, J.5
  • 52
    • 0037277605 scopus 로고    scopus 로고
    • Biological rhythms, endothelial health and cardiovascular disease
    • Walters J, Skene D, Hampton SM, Ferns GA. Biological rhythms, endothelial health and cardiovascular disease. Med Sci Monit. 2003;9:RA1-8.
    • (2003) Med Sci Monit , vol.9
    • Walters, J.1    Skene, D.2    Hampton, S.M.3    Ferns, G.A.4
  • 53
    • 0038652065 scopus 로고    scopus 로고
    • Increased renal vascular sensitivity to angiotensin II in hypertension is due to decreased response to prostaglandins
    • Palmgren E, Widgren B, Aurell M, Herlitz H. Increased renal vascular sensitivity to angiotensin II in hypertension is due to decreased response to prostaglandins. J Hypertens. 2003;21:969-976.
    • (2003) J Hypertens , vol.21 , pp. 969-976
    • Palmgren, E.1    Widgren, B.2    Aurell, M.3    Herlitz, H.4
  • 54
    • 0033564781 scopus 로고    scopus 로고
    • Effects of acute angiotensin II type 1 receptor antagonism and angiotensin converting enzyme inhibition on plasma fibrinolytic parameters in patients with heart failure
    • Goodfield NE, Newby DE, Ludlam CA, Flapan AD. Effects of acute angiotensin II type 1 receptor antagonism and angiotensin converting enzyme inhibition on plasma fibrinolytic parameters in patients with heart failure. Circulation. 1999;99:2983-2985.
    • (1999) Circulation , vol.99 , pp. 2983-2985
    • Goodfield, N.E.1    Newby, D.E.2    Ludlam, C.A.3    Flapan, A.D.4
  • 57
    • 0036343065 scopus 로고    scopus 로고
    • Long-term angiotensin-converting enzyme inhibition with ramipril reduces thrombin generation in human hypertension
    • Ekholm M, Wallen NH, Johnsson H, Eliasson K, Kahan T. Long-term angiotensin-converting enzyme inhibition with ramipril reduces thrombin generation in human hypertension. Clin Sci (Lond). 2002;103:151-155.
    • (2002) Clin Sci (Lond) , vol.103 , pp. 151-155
    • Ekholm, M.1    Wallen, N.H.2    Johnsson, H.3    Eliasson, K.4    Kahan, T.5
  • 58
    • 0033960710 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors downregulate tissue factor synthesis in monocytes
    • Napoleone E, Di Santo A, Camera M, Tremoli E, Lorenzet R. Angiotensin-converting enzyme inhibitors downregulate tissue factor synthesis in monocytes. Circ Res. 2000;86:139-143.
    • (2000) Circ Res , vol.86 , pp. 139-143
    • Napoleone, E.1    Di Santo, A.2    Camera, M.3    Tremoli, E.4    Lorenzet, R.5
  • 59
    • 0034834941 scopus 로고    scopus 로고
    • Differential effects of ACE-inhibition and angiotensin II antagonism on fibri-nolysis and insulin sensitivity in hypertensive postmenopausal women
    • Fogari R, Zoppi A, Preti P, Fogari E, Malamani G, Mugellini A. Differential effects of ACE-inhibition and angiotensin II antagonism on fibri-nolysis and insulin sensitivity in hypertensive postmenopausal women. Am J Hypertens. 2001;14:921-926.
    • (2001) Am J Hypertens , vol.14 , pp. 921-926
    • Fogari, R.1    Zoppi, A.2    Preti, P.3    Fogari, E.4    Malamani, G.5    Mugellini, A.6
  • 60
    • 0029976555 scopus 로고    scopus 로고
    • Effect of angiotensin II receptor blockade on fibrinolysis during acute hyperinsulinemia in patients with essential hypertension
    • Seljeflot I, Moan A, Kjeldsen S, Sandvik E, Arnesen H. Effect of angiotensin II receptor blockade on fibrinolysis during acute hyperinsulinemia in patients with essential hypertension. Hypertension. 1996;27:1299-1304.
    • (1996) Hypertension , vol.27 , pp. 1299-1304
    • Seljeflot, I.1    Moan, A.2    Kjeldsen, S.3    Sandvik, E.4    Arnesen, H.5
  • 61
    • 0041385826 scopus 로고    scopus 로고
    • Effect of combined AT1 receptor and aldosterone receptor antagonism on plasminogen activator inhibitor-1
    • Sawathiparnich P, Murphey LJ, Kumar S, Vaughan DE, Brown NJ. Effect of combined AT1 receptor and aldosterone receptor antagonism on plasminogen activator inhibitor-1. J Clin Endocrinol Metab. 2003;88:3867-3873.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3867-3873
    • Sawathiparnich, P.1    Murphey, L.J.2    Kumar, S.3    Vaughan, D.E.4    Brown, N.J.5
  • 62
    • 0036771846 scopus 로고    scopus 로고
    • Angiotensin II AT1 receptor antagonists inhibit platelet adhesion and aggregation by nitric oxide release
    • Kalinowski L, Matys T, Chabielska E, Buczko W, Malinski T. Angiotensin II AT1 receptor antagonists inhibit platelet adhesion and aggregation by nitric oxide release. Hypertension. 2002;40:521-527.
    • (2002) Hypertension , vol.40 , pp. 521-527
    • Kalinowski, L.1    Matys, T.2    Chabielska, E.3    Buczko, W.4    Malinski, T.5
  • 63
    • 0035205749 scopus 로고    scopus 로고
    • Angiotensin receptor blocker losartan suppresses platelet activity by interfering with thromboxane signaling
    • Schwemmer M, Sommer O, Bassenge E. Angiotensin receptor blocker losartan suppresses platelet activity by interfering with thromboxane signaling. Cardiovasc Drugs Ther. 2001;15:301-307.
    • (2001) Cardiovasc Drugs Ther , vol.15 , pp. 301-307
    • Schwemmer, M.1    Sommer, O.2    Bassenge, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.