Bcl-2 and Bax regulation of corneal homeostasis in genetically altered mice

Eye and Contact Lens

Volumn 32, Issue 1, 2006, Pages 3-7

  Robertson, Danielle M ^a   Ladage, Patrick M ^a   Yamamoto, Nobutaka ^a   Jester, James V ^b   Petroll, W Matthew ^a   Cavanagh, H Dwight ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Bax; Bcl 2; Cornea; Epithelium; Homeostasis

Indexed keywords

BROXURIDINE; HOMODIMER; PROTEIN BAX; PROTEIN BCL 2;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DEATH; CELL PROLIFERATION; CELL SURFACE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CORNEA; CORNEA CELL; CORNEA EPITHELIUM; CORNEA STROMA; CORNEA THICKNESS; EPITHELIUM CELL; EYE DEVELOPMENT; EYE MALFORMATION; GENE OVEREXPRESSION; GENETIC MODEL; GENOTYPE; HEALTH STATUS; HOMEOSTASIS; IMAGING; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KNOCKOUT MOUSE; MICROSCOPE; MOUSE; MOUSE STRAIN; NONHUMAN; OPHTHALMOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SCREENING; TRANSGENIC MOUSE; WESTERN BLOTTING; WILD TYPE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL PROLIFERATION; CORNEA; GENE EXPRESSION REGULATION; GENES, BCL-2; GENOTYPE; HOMEOSTASIS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL;

EID: 31944436397     PISSN: 15422321     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ICL.0000156216.37737.B3     Document Type: Article

References (21)

1. Ladage PM, Yamamoto K, Ling L, et al. Corneal epithelial homeostasis following daily and overnight contact lens wear. Contact Lens Anterior Eye 2002;25:11-21.
2. Ladage PM, Yamamoto K, Ren DH, et al. Effects of rigid and soft contact lens daily wear on corneal epithelium, tear lactate dehydrogenase, and bacterial binding to exfoliated epithelial cells. Ophthalmology 2001;108:1279-1288.
3. Cavanagh HD, Ladage PM, Li SL, et al. Effects of daily and overnight wear of a novel hyper oxygen-transmissible soft contact lens on bacterial binding and corneal epithelium: A 13-month clinical trial. Ophthalmology 2002;109:1957-1969.
4. 2 transmissible contact lenses on bacterial binding and corneal epithelium: A 1-year clinical trial. Ophthalmology 2002;109:27-39.
5. Yamamoto K, Ladage PM, Ren DH. Bcl-2 expression in the human cornea. Exp Eye Res 2001;73:247-255.
6. Kuwana T, Newmeyer DD. Bcl-2 family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol 2003;15:691-699.
7. Tsujimoto Y. Cell death regulation by the Bcl-2 protein family in the mitochondria. J Cell Physiol 2003;195:158-167.
8. Danial NN, Korsmeyer SJ. Cell death: Critical control points. Cell 2004;116:205-220.
9. Korsmeyer SJ, Shutter JR, Veis DJ, et al. Bcl-2/Bax: A rheostat that regulates an anti-oxidant pathway and cell death. Semin Cancer Biol 1993;4:327-332.
10. Ling YH, Tornoss C, Perez-Soler R. Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis. J Biol Chem 1998;273:18984-18991.
11. Scatena CD. Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest. J Biol Chem 1998;273:30777-30784.
12. Furukawa Y, Iwase S, Kikuchi J, et al. Phosphorylation of Bcl-2 protein by CDCK kinase during G2/M phases and its role in cell cycle regulation. J Biol Chem 2000;275:21661-21667.
13. Yamamoto K, Ladage PM, Ren DH, et al. Effects of low and hyper Dk rigid gas permeable contact lenses on Bcl-2 expression and apoptosis in the rabbit corneal epithelium. CLAO J 2001;27:137-143.
14. Cavanagh HD. The effects of low- and hyper-Dk contact lenses on corneal epithelial homeostasis. Ophthalmol Clin N Am 2003;16:311-325.
15. Strasser A, Whittingham S, Vaux DL, et al. Enforced BCL-2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA 1991;88:8661-8665.
16. Knudson CM, Tung KSK, Tourtellote WG, et al. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 1995;270:96-99.
17. Li HF, Petroll WM, Moller-Pedersen T, et al. Epithelial and corneal thickness measurements by in vivo confocal microscopy through focusing (CMTF). Curr Eye Res 1997;16:214-221.
18. Ladage PM, Yamamoto K, Ren DH, et al. Proliferation rate of rabbit corneal epithelium during overnight rigid contact lens wear. Invest Ophthalmol Vis Sci 2001;42:2804-2812.
19. Yamamoto K, Ladage PM, Ren DH, et al. Epitope variability of Bcl-2 immunolocalization in the human corneal epithelium. CLAO J 2001;27:221-224.
20. Veis DJ, Sorenson CM, Shutter JR, et al. Bcl-2 deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 1993;75(2):229-240.
21. Lindsten T, Ross AJ, King A, et al. The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues. Molecular Cell 2000;6:1389-1399.