Construction and phase I clinical evaluation of the safety and immunogenicity of a candidate enterotoxigenic Escherichia coli vaccine strain expressing colonization factor antigen CFA/I

Infection and Immunity

Volumn 74, Issue 2, 2006, Pages 1062-1071

  Turner, Arthur K ^a,d   Beavis, Juliet C ^a   Stephens, Jonathan C ^a,e   Greenwood, Judith ^a   Gewert, Cornelia ^a   Thomas, Nicola ^a   Deary, Alison ^a   Casula, Gabriella ^a   Daley, Alexandra ^b   Kelly, Paul ^b   Randall, Roger ^a   Darsley, Michael J ^a,c  

^a Acambis   (United States)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c NATIONAL INSTITUTE OF AGRICULTURAL BOTANY   (United Kingdom)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BACTERIAL VACCINE; CERAVACX; COLONIZATION FACTOR ANTIGEN CFA I; ENTEROAGGREGATIVE ESCHERICHIA COLI HEAT STABLE TOXIN 1; ESCHERICHIA COLI ENTEROTOXIN; GENE PRODUCT; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; LIVE VACCINE; PLACEBO; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; AROC GENE; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELETION MUTANT; DIARRHEA; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG TOLERABILITY; EAST1 GENE; ENZYME LINKED IMMUNOSPOT ASSAY; FEVER; FROZEN SECTION; GASTROINTESTINAL SYMPTOM; GENE; GENE DELETION; GENE MUTATION; GENE VECTOR; GENETIC LINKAGE; HEADACHE; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNOGENICITY; LOOSE FECES; NONHUMAN; NORMAL HUMAN; OMPC GENE; OMPF GENE; OUTPATIENT; PHASE 1 CLINICAL TRIAL; PLASMID; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUICIDE GENE; SUSPENSION CELL CULTURE; VACCINATION; VOMITING;

ADOLESCENT; ADULT; ANTIBODIES, BACTERIAL; CHILD; DOUBLE-BLIND METHOD; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; ESCHERICHIA COLI VACCINES; FEMALE; FIMBRIAE PROTEINS; GENE DELETION; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; PLASMIDS; TREATMENT OUTCOME; VACCINES, ATTENUATED;

EID: 31844445576     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.74.2.1062-1071.2006     Document Type: Article

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