Chronic treatment of DA-8159, a new phosphodiesterase type V inhibitor, attenuates endothelial dysfunction in stroke-prone spontaneously hypertensive rat

Life Sciences

Volumn 78, Issue 11, 2006, Pages 1211-1216

  Choi, Seul Min ^a   Kim, Jee Eun ^a   Kang, Kyung Koo ^a  

^a Dong A Pharmaceutical Company   (South Korea)

Author keywords

DA 8159; Endothelial dysfunction; Hypertension; SHR SP

Indexed keywords

ACETYLCHOLINE; CYCLIC GMP; NITRIC OXIDE; PHOSPHODIESTERASE V INHIBITOR; UDENAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; BODY WEIGHT; BRAIN DAMAGE; BRAIN INFARCTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART WEIGHT; HYPERTENSION; MALE; NONHUMAN; SALT INTAKE; STROKE; SURVIVAL; SYSTOLIC BLOOD PRESSURE; VASCULAR RING; VASODILATATION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; CEREBROVASCULAR ACCIDENT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HEART VENTRICLES; HYPERTENSION; MALE; ORGAN SIZE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PYRIMIDINES; RATS; RATS, INBRED SHR; VASODILATION;

ANIMALIA;

EID: 31744439872     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.06.042     Document Type: Article

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