Mathematical modelling of survival of glioblastoma patients suggests a role for radiotherapy dose escalation and predicts poorer outcome after delay to start treatment

Clinical Oncology

Volumn 18, Issue 2, 2006, Pages 93-103

  Burnet, Neil G ^a,b   Jena, R ^a,b   Jefferies, S J ^a   Stenning, S P ^c   Kirkby, N F ^b,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c MRC CLINICAL TRIALS UNIT   (United Kingdom)

^d UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Delay to start treatment; Glioblastoma; Monte Carlo mathematical modelling; Radiotherapy dose escalation

Indexed keywords

ADULT; ARTICLE; BRAIN CELL; BRAIN TUMOR; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELL DAMAGE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; GLIOBLASTOMA; HUMAN; HYPOXIA; IN VIVO STUDY; MAJOR CLINICAL STUDY; MATHEMATICAL MODEL; MONTE CARLO METHOD; OUTCOMES RESEARCH; PATIENT SAFETY; PREDICTION; PRIORITY JOURNAL; PROBABILITY; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; SIMULATION; THERAPY DELAY; TREATMENT OUTCOME; TUMOR GROWTH;

BRAIN NEOPLASMS; DECISION SUPPORT TECHNIQUES; DOSE FRACTIONATION; GLIOBLASTOMA; HUMANS; MODELS, STATISTICAL; MONTE CARLO METHOD; PROPORTIONAL HAZARDS MODELS; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 31644440269     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clon.2005.08.017     Document Type: Article

References (44)

1. N.G. Burnet S.J. Jefferies R.J. Benson D.P. Hunt F.P. Treasure Years of life lost (YLL) from cancer is an important measure of population burden - and should be considered when allocating research funds Br J Cancer 92 2005 241-245
2. NCRI National Cancer Research Institute strategic analysis 2002 NCRI London
3. N.G. Burnet V.R. Bulusu S.J. Jefferies Management of primary brain tumours S. Booth E. Bruera Palliative care consultations in primary and metastatic brain tumours 2004 Oxford University Press Oxford
4. J.L. Chan S.W. Lee B.A. et al. Fraass Survival and failure patterns of high-grade gliomas after three-dimensional conformal radiotherapy J Clin Oncol 20 2002 1635-1642
5. B.G. Baumert J. Lutterbach R. Bernays J.B. Davis F.L. Heppner Fractionated stereotactic radiotherapy boost after post-operative radiotherapy in patients with high-grade gliomas Radiother Oncol 67 2003 183-190
6. M.M. Fitzek A.F. Thornton J.D. Rabinov et al. Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: Results of a phase II prospective trial J Neurosurg 91 1999 251-260
7. N.G. Burnet R.J. Benson M.V. Williams J.H. Peacock Improving cancer outcomes through radiotherapy. Lack of UK radiotherapy resources prejudices cancer outcomes BMJ 320 2000 198-199
8. V. Do V. Gebski M.B. Barton The effect of waiting for radiotherapy for grade III/IV gliomas Radiother Oncol 57 2000 131-136
9. W.H. Press S.A. Tenkolsky W.T. Vetterling B.P. Flannery Fortran numerical recipes in Fortran 90 1996 Cambridge University Press Cambridge
10. Burnet NG, Jena R, Jefferies SJ, Kirkby NF. A biochemical engineering approach to neuro-oncology: Modelling the biology of brain tumours. Seventh World Congress of Chemical Engineering, CD of Congress Manuscripts, Glasgow, 10-14 July, O82-001, 2005:1-13.
11. C.M. West S.E. Davidson S.A. Roberts R.D. Hunter Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix Br J Cancer 68 1993 819-823
12. T. Bjork-Eriksson C.M. West E. Karlsson et al. The in vitro radiosensitivity of human head and neck cancers Br J Cancer 77 1998 2371-2375
13. J. Peacock A. Ashton J. Bliss et al. Cellular radiosensitivity and complication risk after curative radiotherapy Radiother Oncol 55 2000 173-178
14. A.C. Begg G.G. Steel Cell proliferation and growth rate of tumours G.G. Steel Basic clinical radiobiology 3rd edn 2002 Arnold London 8-22
15. F.G. Blankenberg R.L. Teplitz W. Ellis et al. The influence of volumetric tumor doubling time, DNA ploidy, and histologic grade on the survival of patients with intracranial astrocytomas Am J Neuroradiol 16 1995 1001-1012
16. K. Tsuboi Y. Yoshii K. Nakagawa Y. Maki Regrowth patterns of supratentorial gliomas: Estimation from computed tomographic scans Neurosurgery 19 1986 946-951
17. M.D. Walker T.A. Strike G.E. Sheline An analysis of dose-effect relationship in the radiotherapy of malignant gliomas Int J Radiat Oncol Biol Phys 5 1979 1725-1731
18. Jena R, Price SJ, Baker C, et al. Diffusion tensor imaging: Possible implications for radiotherapy treatment planning of patients with high-grade glioma. Clin Oncol 2005;17:581-590.
19. A. Taghian J. Ramsay J. Allalunis-Turner et al. Intrinsic radiation sensitivity may not be the major determinant of the poor clinical outcome of glioblastoma multiforme Int J Radiat Oncol Biol Phys 25 1993 243-249
20. J. Deacon M.J. Peckham G.G. Steel The radioresponsiveness of human tumours and the initial slope of the cell survival curve [review] Radiother Oncol 2 1984 317-323
21. R.H. Thomlinson L.H. Gray The histological structure of some human lung cancers and the possible implications for radiotherapy Br J Cancer 9 1955 539-549
22. N.M. Bleehen S.P. Stenning A Medical Research Council trial of two radiotherapy doses in the treatment of grades 3 and 4 astrocytoma. The Medical Research Council Brain Tumour Working Party Br J Cancer 64 1991 769-774
23. M. Stuschke V. Budach W. Budach H.J. Feldmann H. Sack Radioresponsiveness, sublethal damage repair and stem cell rate in spheroids from three human tumor lines: Comparison with xenograft data Int J Radiat Oncol Biol Phys 24 1992 119-126
24. M. Stuschke V. Budach R.L. Kalff et al. Spheroid control of malignant glioma cell lines after fractionated irradiation: Relation to the surviving fractions at 2 Gy and colony forming efficiencies in a soft agar clonogenic assay Radiother Oncol 27 1993 245-251
25. W. Budach D. Gioioso A. Taghian M. Stuschke H.D. Suit Repopulation capacity during fractionated irradiation of squamous cell carcinomas and glioblastomas in vitro Int J Radiat Oncol Biol Phys 39 1997 743-750
26. A. Taghian H. Suit F. Pardo et al. In vitro intrinsic radiation sensitivity of glioblastoma multiforme Int J Radiat Oncol Biol Phys 23 1992 55-62
27. J. Ramsay R. Ward N.M. Bleehen Radiosensitivity testing of human malignant gliomas Int J Radiat Oncol Biol Phys 24 1992 675-680
28. A. Taghian W. DuBois W. Budach M. Baumann J. Freeman H. Suit In vivo radiation sensitivity of glioblastoma multiforme Int J Radiat Oncol Biol Phys 32 1995 99-104
29. G.G. Steel T.E. Wheldon The radiation biology of paediatric tumours P.N. Plowman C.R. Pinkerton Paediatric oncology: Clinical practice and controversies 1992 Chapman and Hall London
30. 2 distribution and bioreductive enzymes in human malignant brain tumors Int J Radiat Oncol Biol Phys 29 1994 427-431
31. E.J. Hall Radiobiology for the radiologist 3rd edn 1988 Lippincott Philadelphia
32. M.A. Richards A.M. Westcombe S.B. Love P. Littlejohns A.J. Ramirez Influence of delay on survival in patients with breast cancer: A systematic review Lancet 353 1999 1119-1126
33. W.J. Mackillop J.H. Bates B. O'Sullivan H.R. Withers The effect of delay in treatment on local control by radiotherapy Int J Radiat Oncol Biol Phys 34 1996 243-250
34. S.J. Price A. Pena N.G. Burnet et al. Tissue signature characterisation of diffusion tensor abnormalities in cerebral gliomas Eur Radiol 14 2004 1909-1917
35. H. Suit The Gray Lecture 2001: Coming technical advances in radiation oncology Int J Radiat Oncol Biol Phys 53 2002 798-809
36. J.C. Horiot R. Le Fur T. N'Guyen et al. Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: Final analysis of a randomized trial of the EORTC cooperative group of radiotherapy Radiother Oncol 25 1992 231-241
37. R. Jena N.G. Burnet S.J. Price et al. Diffusion tensor imaging: application of a novel imaging technique for radiotherapy treatment planning of patients with high grade glioma Radiother Oncol 73 suppl 1 2004 S40
38. K.R. Swanson E.C. Alvord Jr. J.D. Murray Virtual brain tumours (gliomas) enhance the reality of medical imaging and highlight inadequacies of current therapy Br J Cancer 86 2002 14-18
39. M.A. Chaplain Mathematical modelling of angiogenesis J Neurooncol 50 2000 37-51
40. H.M. Byrne M.A. Chaplain Mathematical models for tumour angiogenesis: numerical simulations and nonlinear wave solutions Bull Math Biol 57 1995 461-486
41. H.A. Levine B.D. Sleeman M. Nilsen-Hamilton Mathematical modeling of the onset of capillary formation initiating angiogenesis J Math Biol 42 2001 195-238
42. T. Alarcon H.M. Byrne P.K. Maini A cellular automaton model for tumour growth in inhomogeneous environment J Theor Biol 225 2003 257-274
43. N.F. Kirkby N.G. Burnet D.B.F. Faraday Mathematical modelling of the response of tumour cells to radiotherapy Nucl Instrum Methods Phys Res B 188 2002 210-215
44. N.F. Kirkby D.B.F. Faraday S.C. Short M. Wookcock M.C. Joiner N.G. Burnet Mathematical modelling to develop a novel radiotherapy schedule for high grade brain tumours based on phase distribution of low-dose hypersensitivity in human glioma cell lines Radiother Oncol 64 suppl 1 2002 S57