Interleukin-15 enhances the secretion of IFN-γ and CC chemokines by natural killer cells from HIV viremic and aviremic patients

Immunology Letters

Volumn 103, Issue 2, 2006, Pages 192-195

  D'Ettorre, Gabriella ^a   Andreotti, Mauro ^b   Carnevalini, Martina ^a   Andreoni, Carolina ^a   Zaffiri, Lorenzo ^a   Vullo, Vincenzo ^a   Vella, Stefano ^b   Mastroianni, Claudio M ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

CC chemokines; HIV; IL 15; NK cells

Indexed keywords

BETA CHEMOKINE; CD69 ANTIGEN; GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 12; RECOMBINANT INTERLEUKIN 15;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOTHERAPY; IN VITRO STUDY; INTERFERON PRODUCTION; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; VIREMIA; VIRUS REPLICATION;

ADULT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELLS, CULTURED; CHEMOKINE CCL4; CHEMOKINES, CC; FEMALE; HIV; HIV INFECTIONS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-15; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; VIREMIA;

EID: 31544481863     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2005.10.001     Document Type: Article

References (15)

1. D. Mitsuyasu Immune therapy: non-highly active antiretroviral therapy management of human immunodeficiency virus-infected patients J Infect Dis 185 2002 S115 S122
2. C.M. Mastroianni, G. d'Ettorre, G. Forcina, and V. Vullo Teaching tired T cells to fight HIV: time to test IL-15 for immunotherapy? Trends Immunol 25 2004 122 125
3. C.M. Mastroianni, G. d'Ettorre, G. Forcina, M. Lichtner, F. Mengoni, and C. D'Agostino Interleukin-15 enhances neutrophil functional activity in patients with human immunodeficiency virus infection Blood 96 2000 1979 1984
4. G. d'Ettorre, G. Forcina, M. Lichtner, F. Mengoni, C. D'Agostino, and A.P. Massetti Interleukin-15 in HIV infection: immunological and virological interactions in antiretroviral-naive and -treated patients AIDS 16 2002 181 188
5. Y.M. Mueller, P.M. Bojczuk, E.S. Halstead, A.H. Kim, J. Witek, and J.D. Altman IL-15 enhances survival and function of HIV-specific CD8+ T cells Blood 101 2003 1024 1029
6. S. Oh, J.A. Berzofsky, D.S. Burke, T.A. Waldmann, and L.P. Perera Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity PNAS 100 2003 3392 3397
7. Y.M. Mueller, C. Petrovas, P.M. Bojczuk, I.D. Dimitriou, B. Beer, and P. Silvera Interleukin-15 increases effector memory CD8+ T cells and NK cells in simian immunodeficiency virus-infected macaques J Virol 79 2005 4877 4885
8. S. Kottilil, T.W. Chun, S. Moir, S. Liu, M. McLaughlin, and C.W. Hallahan Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell function J Infect Dis 187 2003 1038 1045
9. A. Oliva, A.L. Kinter, M. Vaccarezza, A. Rubbert, A. Catanzaro, and S. Moir Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitro J Clin Invest 102 1998 223 231
10. M. Fogli, P. Costa, G. Murdaca, M. Setti, M.C. Mingari, and L. Moretta Significant NK cell activation associated with decreased cytolytic function in peripheral blood of HIV-1-infected patients Eur J Immunol 34 2004 2313 2321
11. G. Alter, J.M. Malenfant, R.M. Delabre, N.C. Burgett, X.G. Yu, and M. Lichterfeld Increased natural killer cell activity in viremic HIV-1 infection J Immunol 173 2004 5305 5311
12. M.R. Goodier, N. Imami, G. Moyle, B. Gazzard, and F. Gotch Loss of the CD56hiCD16-NK cell subset and NK cell interferon-gamma production during antiretroviral therapy for HIV-1: partial recovery by human growth hormone Clin Exp Immunol 134 2003 470 476
13. G. Forcina, G. D'Ettorre, C.M. Mastroianni, M. Carnevalini, L. Scorzolini, and G. Ceccarelli Interleukin-15 modulates interferon-gamma and beta-chemokine production in patients with HIV infection: implications for immune-based therapy Cytokine 25 2004 283 290
14. + natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals Proc Natl Acad Sci USA 102 2005 2886 2891
15. T.A. Fehniger, M.H. Shah, M.J. Turner, J.B. VanDeusen, S.P. Whitman, and M.A. Cooper Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response J Immunol 162 1999 4511 4520