Application of branched-chain amino acids in human pathological states: Renal failure

Journal of Nutrition

Volumn 136, Issue 1, 2006, Pages

  Cano, Noël J M ^a   Fouque, Denis ^b   Leverve, Xavier M ^c  

^a Clinique Residence du Parc   (France)

^b EDOUARD HERRIOT HOSPITAL   (France)

^c INSERM   (France)

Author keywords

Branched chain amino acids; Low protein diets; Nutrition; Protein metabolism; Renal failure; Valine, leucine

Indexed keywords

2 OXOISOVALERATE DEHYDROGENASE (LIPOAMIDE); BRANCHED CHAIN AMINO ACID;

AMINO ACID METABOLISM; BRAIN FUNCTION; CONFERENCE PAPER; DIALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; HEMODIALYSIS; HUMAN; HYPERPARATHYROIDISM; INSULIN SENSITIVITY; KIDNEY FAILURE; KIDNEY TUBULE ACIDOSIS; NITROGEN METABOLISM; PROTEIN INTAKE;

EID: 31544476248     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.1.299s     Document Type: Conference Paper

References (121)

1. Cano N. Branched-chain amino and keto acids in renal failure. In: Cynober LA, editor. Metabolic and therapeutic aspects of amino acids in clinical nutrition. Washington, D.C.: CRC Press; 2004. p. 557-76.
2. Fouque D. Influence of dietary protein intake on the progression of chronic renal insufficiency. In: Kopple JD, Massry SG, editors. Nutritional management of renal disease. 2nd edition. Philadelphia: Lippincott, Williams and Wilkins; 2004. p. 241-49.
3. Mogielnicki RP, Waldmann TA, Strober W. Renal handling of low molecular weight proteins. I. L-chain metabolism in experimental renal disease. J Clin Invest. 1971;50:901-9.
4. Pitts RF, Damian AC, Mac Leod MB. Synthesis of serine by rat kidney in vivo and in vitro. Am J Physiol. 1970;219:584-9.
5. Guder WG, Morel F. Biochemical characterization of individual neprhon segments. In: Windhager EE, editor. Handbook of physiology, Section 8: renal physiology. Vol. 2. New York: Oxford University Press; 1992. p. 2119-64.
6. Pitts RF. Régulation de l'équilibre acido-basique. In: Pitts RF, editor. Physiologie du rein et du milieu intérieur. Paris: Masson; 1970. p. 172-202.
7. Tannen RL. Ammonia metabolism. Am J Physiol. 1978;235:F265-77.
8. Kuhlmann MK, Kopple JD. Amino acid metabolism in the kidney. Semin Nephrol. 1990;10:445-57.
9. Tizianello A, Deferrari G, Garibotto G, Robaudo C, Lutman M, Passerone G, Bruzzone M. Branched-chain amino acid metabolism in chronic renal failure. Kidney Int Suppl. 1983;16:S17-22.
10. Vinay P, Lemieux G, Gougoux A, Halperin M. Regulation of glutamine metabolism in dog kidney in vivo. Kidney Int. 1986;29:68-79.
11. Schoolwerth AC. Regulation of renal ammoniagenesis in metabolic acidosis. Kidney Int. 1991;40:961-73.
12. Boon L, Blommaart PJ, Meijer AJ, Lamers WH, Schoolwerth AC. Acute acidosis inhibits liver amino acid transport: no primary role for the urea cycle in acid-base balance. Am J Physiol. 1994;267:F1015-20.
13. Wang X, Price SR. Differential regulation of branched-chain alphaketoacid dehydrogenase kinase expression by glucocorticoids and acidification in LLC-PK1-GR101 cells. Am J Physiol Renal Physiol. 2004;286:F504-8.
14. Jones MR, Kopple JD. Valine metabolism in normal and chronically uremic man. Am J Clin Nutr. 1978;31:1660-4.
15. Alvestrand A, Fürst P, Bergström J. Intracellular aminoacids in uremia. Kidney Int Supp. 1983;24:S9-S16.
16. Bergström J, Alvestrand A, Fürst P. Plasma and muscle free amino acids in maintenance hemodialysis patients without protein malnutrition. Kidney Int. 1990;38:108-14.
17. Smolin LA, Laidlaw SA, Kopple JD. Altered plasma free and protein-bound sulfur amino acid levels in patients undergoing maintenance hemodialysis. Am J Clin Nutr. 1987;45:737-43.
18. Riedel E, Hampl H, Nundel M, Farshidfar G. Essential branched-chain amino acids and alpha-ketoanalogues in haemodialysis patients. Nephrol Dial Transplant. 1992;7:117-20.
19. Lindholm B, Alvestrand A, Fürst P, Bergström J. Plasma and muscle free amino acids during continuous ambulatory peritoneal dialysis. Kidney Int. 1989;35:1219-26.
20. Kist-van Holthe tot Echten JHuijmans JG, Hop WC, Monnens LA, de Jong MC, Noordzij CM, Slotema R, Nauta J, Wolff ED. Intracellular amino acid concentrations in children with chronic renal insufficiency. Pediatr Nephrol. 1996;10:46-50.
21. Raj DS, Ouwendyk M, Francoeur R, Pierratos A. Plasma amino acid profile on nocturnal hemodialysis. Blood Purif. 2000;18:97-102.
22. Kooman JP, Deutz NE, Zijlmans P, van den Wall Bake A, Gerlag PG, van Hooff JP, Leunissen KM. The influence of bicarbonate supplementation on plasma levels of branched-chain amino acids in haemodialysis patients with metabolic acidosis. Nephrol Dial Transplant. 1997;12:2397-401.
23. Kikuchi F, Kuno T, Nagura Y, Takahashi S, Kanmatsuse K. The influence of correction of acidosis on plasma level of branched-chain amino acids in chronic hemodialysis patients. Nippon Jinzo Gakkai Shi. 1998;40:258-62.
24. Scolari MP, Stefoni S, Mosconi G, Coli L, Feliciangeli G, Baldrati L, Buscaroli A, Prandini R, Bonomini V. Effects of renal substitutive programs on amino acid patterns in chronic uremia. Kidney Int Suppl. 1983;24: suppl. 16:S77-80.
25. Perfumo F, Canepa A, Divino Filho JC, Nilsson E, Carrea A, Verrina E, Gusmano R, Bergström J. Muscle and plasma amino acids and nutritional status in kidney-transplanted children. Nephrol Dial Transplant. 1994;9:1778-85.
26. Dalton RN, Chantler C. The relationship between branched-chain amino acids and alpha-keto acids in blood in uremia. Kidney Int Suppl. 1983;16:S61-6.
27. Jones R, Dalton N, Turner C, Start K, Haycock G, Chantler C. Oral essential aminoacid and ketoacid supplements in children with chronic renal failure. Kidney Int. 1983;24:95-103.
28. Arai J, Hara Y, Fukuda S, Takuma T, Sugino N. Metabolic conversion of alpha-keto valine to valine in patients with chronic renal failure. Clin Nephrol. 1985;23:236-40.
29. Schauder P, Matthaei D, Henning HV, Scheler F, Langenbeck U. Blood levels of branched-chain amino acids and alpha-ketoacids in uremic patients given keto analogues of essential amino acids. Am J Clin Nutr. 1980;33:1660-6.
30. Walser M, Jarskog FL, Hill SB. Branched-chain-ketoacid metabolism in patients with chronic renal failure. Am J Clin Nutr. 1989;50:807-13.
31. Garibotto G, Paoletti E, Fiorini F, Russo R, Robaudo C, Deferrari G, Tizianello A. Peripheral metabolism of branched-chain keto acids in patients with chronic renal failure. Miner Electrolyte Metab. 1993;19:25-31.
32. Felig P. Amino acid metabolism in man. Annu Rev Biochem. 1975;44:933-55.
33. Abumrad MM, Miller B. The physiologic and nutritional significance of plasma-free amino acid levels. JPEN J Parenter Enteral Nutr. 1983;7:163-70.
34. Wahren J, Felig P, Hagenfeld L. Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J Clin Invest. 1976;57:987-99.
35. Deferrari G, Garibotto G, Robaudo C, Sala M, Tizianello A. Splanchnic exchange of amino acids after amino acid ingestion in patients with chronic renal insuffiency. Am J Clin Nutr. 1988;48:72-83.
36. Tizianello A, Deferrari G, Garibotto G, Robaudo C. Amino acid metabolism and the liver in renal failure. Am J Clin Nutr. 1980;33:1354-62.
37. Garibotto G, Deferrari G, Robaudo C, Saffioti S, Salvidio G, Paoletti E, Tizianello A. Effect of amino acid ingestion on blood amino acid profile in patients with chronic renal failure. Am J Clin Nutr. 1987;46:949-54.
38. Garibotto G, Deferrari G, Robaudo C, Saffioti S, Paoletti E, Pontremoli R, Tizianello A. Effects of a Protein Meal on Blood Amino Acid Profile in Patients with Chronic Renal Failure. Nephron. 1993;64:216-25.
39. Garibotto G, Deferrari G, Robaudo C, Saffioti S, Sofia A, Russo R, Tizianello A. Disposal of exogenous amino acids by muscle in patients with chronic renal failure. Am J Clin Nutr. 1995;62:136-42.
40. Cupisti A, Baker F, Brown J, Lock C, Bevington A, Harris KPG, Walls J. Effects of Acid Loading on Serum Amino Acid Profiles and Muscle Composition in Normal Fed Rats. Clin Sci. 1993;85:445-9.
41. Christensen HN. Interorgan amino acid nutrition. Physiol Rev. 1982;62:1193-233.
42. Deferrari G, Garibotto G, Robaudo C, Canepa A, Bagnasco S, Tizianello A. Leg metabolism of amino acids and ammonia in patients with chronic renal failure. Clin Sci (Lond). 1985;69:143-51.
43. Garibotto G, Russo R, Sofia A, Sala MR, Robaudo C, Moscatelli P, Deferrari G, Tizianello A. Skeletal muscle protein synthesis and degradation in patients with chronic renal failure. Kidney Int. 1994;45:1432-9.
44. Lim VS, Yarasheski KE, Flanigan MJ. The effect of uraemia, acidosis, and dialysis treatment on protein metabolism: a longitudinal leucine kinetic study. Nephrol Dial Transplant. 1998;13:1723-30.
45. May RC, Hara Y, Kelly RA, Block KP, Muse MG, Mitch WE. Branchedchain amino acid metabolism in rat muscle: abnormal regulation in acidosis. Am J Physiol. 1987;252:E712-8.
46. Price SR, Wang X, Bailey JL. Tissue-specific responses of branchedchain alpha-ketoacid dehydrogenase activity in metabolic acidosis. J Am Soc Nephrol. 1998;9:1892-8.
47. May RC, Kelly RA, Mitch WE. Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism. J Clin Invest. 1986;77:614-21.
48. Wing SS, Goldberg AL. Glucocorticoids activate the ATP-ubiquitindependent proteolytic system in skeletal muscle during fasting. Am J Physiol. 1993;264:E668-76.
49. Block KP, Richmond WB, Mehard WB, Buse MG. Glucocorticoidmediated activation of alpha-keto acid deshydrogenase in vivo. Am J Physiol. 1987;252:E396-407.
50. Mitch WE, Price SR, May RC, Jurkovitz C, England BK. Metabolic consequences of uremia: extending the concept of adaptative responses to protein metabolism. Am J Kidney Dis. 1994;23:224-8.
51. Price SR, England BK, Bailey JL, van Verde K, Mitch WE. Acidosis and glucocorticoids concomitantly increase ubiquitin and proteasome subunit mRNAs in rat muscle. Am J Physiol. 1994;267:C955-60.
52. King P, Goldstein L, Newsholme EA. Glutamine synthtease activity of muscle in acidosis. Biochem J. 1983;216:523-5.
53. Welbourne TC, Joshi S. Interorgan glutamine metabolism during acidosis. JPEN J Parenter Enteral Nutr. 1990;14:77S-85S.
54. Lim VS, Bier DM, Flanigan MJ, Sum-Ping ST. The effect of hemodialysis on protein metabolism. A leucine kinetic study. J Clin Invest. 1993;91:2429-36.
55. Raj DS, Welbourne T, Dominic EA, Waters D, Wolfe R, Ferrando A. Glutamine kinetics and protein turnover in end-stage renal disease. Am J Physiol Endocrinol Metab. 2005;288:E37-46.
56. Lim VS, Yarasheski KE, Crowley JR, Fangman J, Flanigan M. Insulin is protein-anabolic in chronic renal failure patients. J Am Soc Nephrol. 2003;14:2297-304.
57. Tizianello A, Deferrari G, Garibotto G, Robaudo C, Canepa A, Passerone G. Is amino acid imbalance harmful to patients in chronic renal failure? Kidney Int Suppl. 1985;17:S79-83.
58. Young VR, Bier DM, Pelett PL. A theoretical basis for increasing current estimates of the amino acid requirements in adult man, with experimental support. Am J Clin Nutr. 1989;50:80-92.
59. Young VR, Marchini JS. Mechanisms and nutritional significance of metabolic responses to altered intakes of protein and amino acids with reference to nutritional adaptation in humans. Am J Clin Nutr. 1990;51:270-89.
60. Oldendorf WH, Szabo J. Amino acid assignment to one of the three bloodbrain barrier amino acid carriers. Am J Physiol. 1976;230:94-8.
61. Deferrari G, Garibotto G, Robaudo C, Ghiggeri GM, Tizianello A. Brain metabolism of amino acids and ammonia in patients with chronic renal insuf-ficiency. Kidney Int. 1981;20:505-10.
62. Deferrari G, Garibotto G, Robaudo C, Canepa A, Passerone GC, Tizianello A. Brain metabolism in uremia. In: Kleinberger G, Ferenci P, Riederer P, Thaler H, editors. Advances in hepatic encephalopathy and urea cycle diseases. Basel: Karger; 1984. p. 484-98.
63. Pye IF, Mac Gale EHF, Stomier C, Hutchinson EC, Aben GM. Studies of cerebrospinal fluid and plasma amino acids in patients with steady-state chronic renal failure. Clin Chim Acta. 1979;92:65-72.
64. Gerrits GP, Kamphuis S, Monnens LA, Trijbels JM, Schroder CH, Koster A, Gabreels FJ. Cerebrospinal fluid levels of amino acids in infants and young children with chronic renal failure. Neuropediatrics. 1998;29:35-9.
65. Cusick PK, Koehler KM, Ferrier B, Haskell BE. The neurotoxicity of valine deficiency in rats. J Nutr. 1978;108:1200-6.
66. Palaiologos G, Koivisto VA, Felig P. Interaction of leucine, glucose, and ketone metabolism in rat brain in vitro. J Neurochem. 1979;32:67-72.
67. Reith ME, Schotman P, Van Zwieten BJ, Gispen WH. The nature of amino acid pool used for protein synthesis in rat brain slices. J Neurochem. 1979;32:413-20.
68. Dhopeshwarkar GA, Subramian C. Lipogenesis in developping brain: utilization of radioactive leucine, isoleucine, octanoic acid and beta-hydroxybutyrique acid. Lipids. 1979;14:47-51.
69. Roberts S, Morelos BS. Regulation of cerebral metabolism of amino acids: IV. Influence of amino acid levels on leucine uptake, utilisation and incorporation into protein in vivo. J Neurochem. 1965;12:373-87.
70. Hamberger AC, Chiang GH, Nylen ES, Scheff SW, Cotman CW. Glutamate as a CNS transmitter. I-Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate. Brain Res. 1979;168:513-30.
71. Soreide E, Skeie B, Kirvela O, Lynn R, Ginsberg N, Manner T, Katz DP, Askanazi J. Branched-chain amino acid in chronic renal failure patients: respiratory and sleep effects. Kidney Int. 1991;40:539-43.
72. Hiroshige K, Sonta T, Suda T, Kanegae K, Ohtani A. Oral supplementation of branched-chain amino acid improves nutritional status in elderly patients on chronic haemodialysis. Nephrol Dial Transplant. 2001;16:1856-62.
73. Young GA, Swanepoel CR, Croft MR, Hobson SM, Parsons FM. Anthropometry and plasma valine, amino acids, and proteins in the nutritional assessment of hemodialysis patients. Kidney Int. 1982;21:492-9.
74. Chazot C, Laurent G, Charra B, Blanc C. VoVan C, Jean G, Vanel T, Terrat JC, Ruffet M. Malnutrition in long-term haemodialysis survivors. Nephrol Dial Transplant. 2001;16:61-9.
75. Cano N, Labastie-Coeyrehourcq J, Lacombe P, Stroumza P, di Costanzo-Dufetel J, Durbec JP, Coudray-Lucas C, Cynober L. Perdialytic parenteral nutrition with lipids and amino-acids in malnourished hemodialysis patients. Am J Clin Nutr. 1990;52:726-30.
76. Toigo G, Aparicio M, Attman P-O, Cano N, Ciancaruso D, Fouque D, Heidland A, Howard P, Teplan V, Guarnieri G. ESPEN consensus on nutritional treatment of patients with renal insufficiency (Part 1 of 2). Clin Nutr. 2000;19:197-207.
77. Toigo G, Aparicio M, Attman P-O, Cano N, Ciancaruso D, Fouque D, Heidland A, Howard P, Teplan V, Guarnieri G. ESPEN consensus on nutritional treatment of patients with renal insufficiency (Part 2 of 2). Clin Nutr. 2000;19:281-91.
78. Clinical practice guidelines for nutrition in chronic renal failure. K/DOQI, National Kidney Foundation. I. Adult guidelines. A. Maintenance dialysis. Am J Kidney Dis. 2000;35(suppl 2):S17-S55.
79. Clinical practice guidelines for nutrition in chronic renal failure. K/DOQI, National Kidney Foundation. I. Adult guidelines. B. Advanced chronic renal failure without dialysis. Am J Kidney Dis. 2000;35(suppl 2):S56-S65.
80. Clinical practice guidelines for nutrition in chronic renal failure. K/DOQI, National Kidney Foundation. II. Pediatric guidelines. Am J Kidney Dis. 2000;35 (suppl 2):S105-S136.
81. Walser M. Rationale and indications for the use of alpha-keto analogues. JPEN J Parenter Enteral Nutr. 1984;8:37-41.
82. Walser M, Coulter AW, Dighe S, Crantz FR. The effects of keto-analogues of essential amino acids in uremia. J Clin Invest. 1973;52:678-90.
83. Mitch WE, Walser M, Steinman TI, Hill S, Zeger S, Tungsanga K. The effect of a keto acid-amino acid supplement to a restricted diet on the progression of chronic renal failure. N Engl J Med. 1984;311:623-9.
84. Eriksson LS, Hagenfeldt L, Wahren J. Intravenous infusion of alphaoxoisocaproate: influence on amino acid and nitrogen metabolism in patients with liver cirrhosis. Clin Sci (Lond). 1982;62:285-93.
85. Fouin-Fortunet H, Besnier MO, Colin R, Wessely JY, Rose F. Effects of ketoacids on liver glutathione and microsomal enzymes in malnourished rats. Kidney Int Suppl. 1989;27:S222-6.
86. Goodship TH, Mitch WE, Hoerr RA, Wagner DA, Steinman TI, Young VR. Adaptation to low-protein diets in renal failure: leucine turnover and nitrogen balance. J Am Soc Nephrol. 1990;1:66-75.
87. Giordano M, De Feo P, Lucidi P, DePascale E, Giordano G, Cirillo D, Dardo G, Signorelli SS, Castellino P. Effects of dietary protein restriction on fibrinogen and albumin metabolism in nephrotic patients. Kidney Int. 2001;60:235-42.
88. Bernhard J, Beaufrere B, Laville M, Fouque D. Adaptive response to a lowprotein diet in predialysis chronic renal failure patients. J Am Soc Nephrol. 2001;12:1249-54.
89. Masud T, Young VR, Chapman T, Maroni BJ. Adaptive responses to very low protein diets: the first comparison of ketoacids to essential amino acids. Kidney Int. 1994;45:1182-92.
90. Tom K, Young VR, Chapman T, Masud T, Akpele L, Maroni BJ. Long-term adaptive responses to dietary protein restriction in chronic renal failure. Am J Physiol. 1995;268:E668-77.
91. Aparicio M, Bouchet JL, Gin H, Potaux L, Morel D, de Precigout V, Lifermann F, Gonzalez R. Effect of a low-protein diet on urinary albumin excretion in uremic patients. Nephron. 1988;50:288-91.
92. Kaysen GA, Gambertoglio J, Jimenez I, Jones H, Hutchinson FN. Effects of dietary protein intake on albumin homeostasis in nephrotic patients. Kidney Int. 1986;29:572-7.
93. Rosenberg ME, Swanson JE, Thomas BL, Hostetter TH. Glomerular and hormonal responses to dietary protein intake in human renal disease. Am J Physiol. 1987;253:F1083-90.
94. Rigalleau V, Combe C, Blanchetier V, Aubertin J, Aparicio M, Gin H. Low protein diet in uremia: effects on glucose metabolism and energy production rate. Kidney Int. 1997;51:1222-7.
95. Goldwasser P, Mittman N, Antignani A, Burell D, Michel MA, Collier J, Avram MM. Predictors of mortality in hemodialysis patients. J Am Soc Nephrol. 1993;3:1616-22.
96. Avram MM, Mittman N, Bonomini L, Chattopadhyay J, Fein P. Markers for survival in dialysis: a seven-year prospective study. Am J Kidney Dis. 1995;26:209-19.
97. Soucie JM, McClellan WM. Early death in dialysis patients: risk factors and impact on incidence and mortality rates. J Am Soc Nephrol. 1996;7:2169-75.
98. Aparicio M, Chauveau P, Combe C. Are supplemented low-protein diets nutritionally safe? Am J Kidney Dis. 2001;37: Suppl 2:S71-6.
99. Ihle BU, Becker GJ, Whitworth JA, Charlwood RA, Kincaid-Smith PS. The effect of protein restriction on the progression of renal insufficiency. N Engl J Med. 1989;321:1773-7.
100. Williams PS, Stevens ME, Fass G, Irons L, Bone JM. Failure of dietary protein and phosphate restriction to retard the rate of progression of chronic renal failure: a prospective, randomized, controlled trial. Q J Med. 1991;81:837-55.
101. Kopple JD, Levey AS, Greene T, Chumlea WC, Gassman JJ, Hollinger DL, Maroni BJ, Merrill D, Scherch LK, et al. Effect of dietary protein restriction on nutritional status in the Modification of Diet in Renal Disease Study. Kidney Int. 1997;52:778-91.
102. Malvy D, Maingourd C, Pengloan J, Bagros P, Nivet H. Effects of severe protein restriction with ketoanalogues in advanced renal failure. J Am Coll Nutr. 1999;18:481-6.
103. Chauveau P, Barthe N, Rigalleau V, Ozenne S, Castaing F, Delclaux C, de Precigout V, Combe C, Aparicio M. Outcome of nutritional status and body composition of uremic patients on a very low protein diet. Am J Kidney Dis. 1999;34:500-7.
104. Coresh J, Walser M, Hill S. Survival on dialysis among chronic renal failure patients treated with a supplemented low-protein diet before dialysis. J Am Soc Nephrol. 1995;6:1379-85.
105. Walser M. Effects of a supplemented very low protein diet in predialysis patients on the serum albumin level, proteinuria, and subsequent survival on dialysis. Miner Electrolyte Metab. 1998;24:64-71.
106. Walser M, Hill S. Can renal replacement be deferred by a supplemented very low protein diet? J Am Soc Nephrol. 1999;10:110-6.
107. Aparicio M, Chauveau P, De Precigout V, Bouchet JL, Lasseur C, Combe C. Nutrition and outcome on renal replacement therapy of patients with chronic renal failure treated by a supplemented very low protein diet. J Am Soc Nephrol. 2000;11:708-16.
108. Fouque D, Wang P, Laville M, Boissel JP. Low protein diets delay endstage renal disease in non-diabetic adults with chronic renal failure. Nephrol Dial Transplant. 2000;15:1986-92.
109. Jungers P, Chauveau P, Ployard F, Lebkiri B, Ciancioni C, Man NK. Comparison of ketoacids and low protein diet on advanced chronic renal failure progression. Kidney Int Suppl. 1987;22:S67-71.
110. Klahr S, Levey AS, Beck GJ, Caggiula AW, Hunsicker L, Kusek JW, Striker G. The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group. N Engl J Med. 1994;330:877-84.
111. Levey AS, Greene T, Beck GJ, Caggiula AW, Kusek JW, Hunsicker LG, Klahr S. Dietary protein restriction and the progression of chronic renal disease: what have all of the results of the MDRD study shown? Modification of Diet in Renal Disease Study group. J Am Soc Nephrol. 1999;10:2426-39.
112. Jefferson LS, Kimball SR. Amino acid regulation of gene expression. J Nutr. 2001;131: 9 Suppl:2460S-6S.
113. Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 2001;15:807-26.
114. Lynch CJ, Hutson SM, Patson BJ, Vaval A, Vary TC. Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats. Am J Physiol Endocrinol Metab. 2002;283:E824-35.
115. Flaim KE, Liao WS, Peavy DE, Taylor JM, Jefferson LS. The role of amino acids in the regulation of protein synthesis in perfused rat liver. II. Effects of amino acid deficiency on peptide chain initiation, polysomal aggregation, and distribution of albumin mRNA. J Biol Chem. 1982;257:2939-46.
116. Volpi E, Mittendorfer B, Wolf SE, Wolfe RR. Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. Am J Physiol. 1999;277:E513-20.
117. Neuhauser M, Ulm A, Leber HW, Schutterle G. Influence of essential amino acids and keto acids on protein metabolism and the anaemia of patients on chronic intermittent haemodialysis. Proc Eur Dial Transplant Assoc. 1977;14:557-62.
118. Ulm A, Neuhauser M, Leber HW. Influence of essential amino acids and keto acids on protein metabolism and anemia of patients on intermittent hemodialysis. Am J Clin Nutr. 1978;31:1827-30.
119. Hecking E, Kohler H, Zobel R, Lemmel EM, Mader H, Opferkuch W, Prellwitz W, Keim HJ, Muller D. Treatment with essential amino acids in patients on chronic hemodialysis: a double blind cross-over study. Am J Clin Nutr. 1978;31:1821-6.
120. Acchiardo S, Moore L, Cockrell S. Effect of essential amino acids (EAA) on chronic hemodialysis (CHD) patients (PTS). Trans Am Soc Artif Intern Organs. 1982;28:608-14.
121. Eustace JA, Coresh J, Kutchey C, Te PL, Gimenez LF, Scheel PJ, Walser M. Randomized double-blind trial of oral essential amino acids for dialysisassociated hypoalbuminemia. Kidney Int. 2000;57:2527-38.