An experimental study on O-[ 18F]fluoromethyl-L-tyrosine for differentiation between tumor and inflammatory tissues

Annals of Nuclear Medicine

Volumn 19, Issue 7, 2005, Pages 589-595

  Suzuki, Manami ^a   Yamaguchi, Keiichiro ^b   Honda, Go ^a   Iwata, Ren ^a   Furumoto, Shozo ^a   Jeong, Myeong Gi ^a   Fukuda, Hiroshi ^a   Itoh, Masatoshi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b SENDAI KOUSEI HOSPITAL   (Japan)

Author keywords

2 deoxy D 1 14C glucose; 18F FDG; Inflammation; O 18F fluoromethyl L tyrosine; Tumor

Indexed keywords

DEOXYGLUCOSE C 14; FLUORINE 18; FLUORINE DERIVATIVE; GLUCOSE DERIVATIVE; O FLUOROMETHYLTYROSINE F 18; TRACER; TURPENTINE OIL; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCITES; AUTORADIOGRAPHY; BACTERIAL INFECTION; CANCER; CANCER MODEL; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE MODEL; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG POTENCY; DRUG SPECIFICITY; DRUG UPTAKE; EXPERIMENTAL INFECTION; HEPATOMA CELL; INFLAMMATION; INOCULATION; MALE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; RADIOACTIVITY; RAT; STAPHYLOCOCCUS AUREUS; TISSUE SPECIFICITY; WHOLE BODY AUTORADIOGRAPHY;

ANIMALS; CARCINOMA, HEPATOCELLULAR; DIAGNOSIS, DIFFERENTIAL; DRUG EVALUATION, PRECLINICAL; MALE; RADIOPHARMACEUTICALS; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STAPHYLOCOCCAL INFECTIONS; TYROSINE;

EID: 31544462592     PISSN: 09147187     EISSN: 09147187     Source Type: Journal    
DOI: 10.1007/BF02985052     Document Type: Article

References (30)

1. Brock CS, Meikle SR, Price P. Does fluorine-18 fluorodeoxyglucose metabolic imaging of tumours benefit oncology? Eur J Nucl Med 1997; 24: 691-705.
2. Rigo P, Paulus P, Kaschten BJ, Hustinx R, Bury T, Jerusalem G, et al. Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose. Eur J Nucl Med 1996; 23: 1641-1674.
3. 18F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation. J Nucl Med 2002; 43: 658-663.
4. 18F-FDG uptake in experimental soft-tissue abscesses in rats. Radiology 2002; 223: 446-451.
5. Kubota R, Kubota K, Yamada S, Tada M, Ido T, Tamahashi N. Microautoradiographic study for the differentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics of fluorine-18- fluorodeoxyglucose uptake. J Nucl Med 1994; 35: 104-112.
6. Kubota R, Yamada S, Kubota K, Ishiwata K, Tamahashi N, Ido T. Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med 1992; 33: 1972-1980.
7. Strauss LG. Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patients. Eur J Nucl Med 1996; 23: 1409-1415.
8. Hustinx R, Smith RJ, Benard F, Rosenthal DI, Machtay M, Farber LA, et al. Dual time point fluorine-18 fluorodeoxyglucose positron emission tomography: a potential method to differentiate malignancy from inflammation and normal tissue in the head and neck. Eur J Nucl Med 1999; 26: 1345-1348.
9. Kubota K, Itoh M, Ozaki K, Ono S, Tashiro M, Yamaguchi K, et al. Advantage of delayed whole-body FDG-PET imaging for tumour detection. Eur J Nucl Med 2001; 28: 696-703.
10. Zhao S, Kuge Y, Tsukamoto E, Mochizuki T, Kato T, Hikosaka K, et al. Effects of insulin and glucose loading on FDG uptake in experimental malignant tumours and inflammatory lesions. Eur J Nucl Med 2001; 28: 730-735.
11. Ishiwata K, Kubota K, Murakami M, Kubota R, Sasaki T, Ishii S, et al. Re-evaluation of amino acid PET studies: can the protein synthesis rates in brain and tumor tissues be measured in vivo? J Nucl Med 1993; 34: 1936-1943.
12. Isselbacher KJ. Sugar and amino acid transport by cells in culture-differences between normal and malignant cells. N Engl J Med 1972; 286: 929-933.
13. Isselbacher KJ. Increased uptake of amino acids and 2-deoxy-D-glucose by virus-transformed cells in culture. Proc Natl Acad Sci USA 1972; 69: 585-589.
14. Kubota R, Kubota K, Yamada S, Tada M, Takahashi T, Iwata R, et al. Methionine uptake by tumor tissue: a microautoradiographic comparison with FDG. J Nucl Med 1995; 36: 484-492.
15. Kubota K, Kubota R, Yamada S, Tada M. Effects of radiotherapy on the cellular uptake of carbon-14 labeled Lmethionine in tumor tissue. Nucl Med Biol 1995; 22: 193-198.
16. Kubota K, Matsuzawa T, Fujiwara T, Sato T, Tada M, Ido T, et al. Differential diagnosis of AH109A tumor and inflammation by radioscintigraphy with L-[methyl-11C]methionine. Jpn J Cancer Res 1989; 80: 778-782.
17. Laverman P, Boerman OC, Corstens FH, Oyen WJ. Fluorinated amino acids for tumour imaging with positron emission tomography. Eur J Nucl Med 2002; 29: 681-690.
18. Jager PL, Vaalburg W, Pruim J, de Vries EG, Langen KJ, Piers DA. Radiolabeled amino acids: basic aspects and clinical applications in oncology. J Nucl Med 2001; 42: 432-445.
19. 18F]fluoroethyl)-L-tyrosine as oncologic PET tracer. Appl Radiat Isot 2003; 58: 219-225.
20. 18F]fluoroethyl)-L-tyrosine in vitro and in vivo. J Nucl Med 1999; 40: 1367-1373.
21. 18F]fluoroethyl)- L-tyrosine for tumor imaging. J Nucl Med 1999; 40: 205-212.
22. Amano S, Inoue T, Tomiyoshi K, Ando T, Endo K. In vivo comparison of PET and SPECT radiopharmaceuticals in detecting breast cancer. J Nucl Med 1998; 39: 1424-1427.
23. 18]fluoro-α-methyl tyrosine: a potential tumor-detecting agent. J Nucl Med 1998; 39: 663-667.
24. 18F]fluorotyrosine, a new PET tracer of protein synthesis. J Nucl Med 1989; 30: 1367-1372.
25. 18F]fluoromethyl-L- tyrosine as potential PET tracers for imaging amino acid transport. J Label Compd Radiopharm 2003; 46: 555-566.
26. 18F] fluoromethyl-L-tyrosine as tumor imaging tracers by PET. Nucl Med Biol 2004; 31: 191-198.
27. Yamada S, Kubota K, Kubota R, Ido T, Tamahashi N. High accumulation of fluorine 18-fluorodeoxyglucose in turpentine-induced inflammatory tissue. J Nucl Med 1995; 36: 1301-1306.
28. 18F-FET uptake in experimental soft tissue infection. Eur J Nucl Med 2002; 29: 648-654.
29. 18FDG). In: Handbook of Radiopharmaceuticals, Welch MJ, Redvanly CS (eds), England; John Wiley & Sons Inc., 2003: 307-322.
30. 11C]methionine. J Nucl Med 1987; 28: 1037-1040.