Biodistribution studies on L-3-[Fluorine-18]Fluoro-α-methyl tyrosine: A potential tumor-detecting agent

Journal of Nuclear Medicine

Volumn 39, Issue 4, 1998, Pages 663-667

  Inoue, Tomio ^a,b   Tomiyoshi, Katsumi ^a   Higuichi, Tetsuya ^a   Ahmed, Khalil ^a   Sarwar, Muhammad ^a   Aoyagi, Keiko ^a   Amano, Shigeko ^a   Alyafei, Saleh ^a   Zhang, Hong ^a   Endo, Keigo ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Biodistribution studies; Fluorine 18 methyl tyrosine; PET

Indexed keywords

ALANINE; FLUORODEOXYGLUCOSE F 18; IODINE 123; IODINE ALPHA METHYL TYROSINE I 123; L3 FLUORO ALPHA METHYL TYROSINE F 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B CELL LYMPHOMA; COMPETITIVE INHIBITION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG UPTAKE; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOISOTOPE DISTRIBUTION; RECTUM CARCINOMA; TUMOR LOCALIZATION;

ALPHA-METHYLTYROSINE; AMINO ACIDS; ANIMALS; BIOLOGICAL TRANSPORT; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; METHYLTYROSINES; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0031949973     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Okada J, Yoshikawa K, Itami M, et al. Positron emission tomography using fluorine-18-fluorodeoxyglucose in malignant lymphoma: a comparison with proliferative activity. J Nucl Med 1992;33:325-329.
2. Gupta NC, Frank AR, Dewan NA, et al. Solitary pulmonary nodules: detection of malignancy with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose. Radiology 1992;184: 441-444.
3. 18F]-fluoro-2-deoxy-D-glucose. Radiology 1991;179:765-770.
4. Strauss LG, Conti PS. The applications of PET in clinical oncology. J Nucl Med 1991;32:623-648.
5. Kubota R, Kubota K, Yamada S, Tada M, Ido T, Tamahashi N. Microautoradiographic study for the differentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics of fluorine-18-fluorodeoxyglucose uptake. J Nucl Med 1994;35:104-112.
6. Kubota R, Kubota K, Yamada S, et al. Methionine uptake by tumor tissue: a microautoradiographic comparison with FDG. J Nucl Med 1995;36:484-492.
7. Ogawa T, Shishido F, Kanno I, et al. Cerebral glioma: evaluation with methionine PET. Radiology 1993;186:45-53.
8. Kubota K, Matsuzawa T, Ito M, et al. Lung tumor imaging by positron emission tomography using C-11 L-methionine. J Nucl Med 1985;26:37-42.
9. Kubota K, Matsuzawa T, Takahashi T, et al. Rapid and sensitive response of carbon-11-L-methionine tumor uptake to irradiation. J Nucl Med 1989;30:2012-2016.
10. Ishiwata K, Kubota K, Murakami M, et al. Re-evaluation of amino acid PET studies: can the protein synthesis rates in brain and tumor tissues be measured in vivo? J Nucl Med 1993;34:1936-1943.
11. 18F]fluorotyrosine in tumor-bearing mice. Nucl Med Biol 1993;20:895-899.
12. 1C]tyrosine and L-[Methyl-carbon-11]methionine to assess liver protein synthesis by PET. J Nucl Med 1996;37:279-285.
13. 18F)fluorotyrosine. J Nucl Med 1991;32:1338-1346.
14. 18F]fluorotyrosine, a new PET tracer of protein synthesis. J Nucl Med 1989;30:1367-1372.
15. Kubota K, Ishiwata K, Kubota R, et al. Feasibility of fluorine- 18-fluorophenylalanine for tumor imaging compared with carbon-11-L-methionine. J Nucl Med 1996;37:320-325.
16. 123I]iodo-α-methyl tyrosine and SPECT. J Nucl Med 1989;30:110-112.
17. 123Iodo-α-methyl-tyrosine: a new potential melanoma seeking compound. Nuklearmedizin 1980;(suppl 17):179-182.
18. 123I-α-methyltyrosine for the non-invasive detection of intraocular melanomas. Nuklearmedizin 1981;(suppl 18):840-844.
19. 18F-α-methyl tyrosine using a separation and purification system. Nucl Med Commun 1997;18:169-175.
20. Neissman A, Koe BK. m-Fluorotyrosine convulsions and mortality; relationship to catecholamine and citrate metabolism. J Pharmacol Exp Ther 1967;155:135-144.
21. Engelman K, Horwitz D, Jéquier E, Sjoerdsma A. Biochemical and pharmacologic effects of α-methyltyrosine in man. J Clin Invest 1968;47:577-594.
22. Tisljar U, Kloster G, Ritzl F, Stöcklin G. Accumulation of radioiodinated L-α-methyltyrosine in pancreas of mice: concise communication. J Nucl Med 1979;20: 973-976.
23. Deehan B, Carnochan P, Trivedi M, Tombs A. Uptake and distribution of L-3-[I-125] iodo-α-methyl tyrosine in experimental rat tumors: comparison with blood flow and growth rate. Eur J Nucl Med 1993;20:101-106.
24. 124IMT and first clinical results. J Nucl Med 1990;31:281-286.
25. 123I-3-iodo-α-methyl tyrosine and preliminary kinetic analysis. Ann Nucl Med 1995;9:47-50.
26. Pardrige WM. Kinetics of competitive inhibition of neutral amino acid transport across the blood-brain barrier. J Neurochem 1977;28:103-108.
27. 123I]iodo-α-methyl tyrosine: competition with natural L-amino acids. J Nucl Med 1991;32:1225-1228.