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31544479742
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note
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If both the ruthenium complex and base loadings are lowered the reaction proceeds significantly slower. As an example, only 13% of 1-octen-3-ol (0.2 M THF, substrate/2b/KO-t-Bu = 5000/1/5) is isomerized after 5.5 hours.
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47
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31544454114
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note
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Catalytic isomerizations of 1-octen-3-ol into 3-octanone performed with 4a, 4b or 4c and KOH in water (substrate/Ru/base = 100/1/5; temperature = 75°C) require 20, 25 and 35 minutes, respectively, to be complete. Exactly the same results are obtained using a mixture of KOH (5 mol %) and tert-butanol (5 mol %), as co-catalyst.
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63
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31544473692
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note
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2O) is quantitatively isomerized into 3-octanone in 30 min using 1 mol % of 4a and 5 mol % of KO-t-Bu.
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