Comparison of carvedilol and metoprolol in patients with acute myocardial infarction undergoing primary coronary intervention - The PASSAT study

Clinical Research in Cardiology

Volumn 95, Issue 1, 2006, Pages 31-41

  Tolg R ^a   Witt, M ^b   Schwarz, B ^a   Kurz, T ^c   Kurowski, V ^c   Hartmann, F ^c   Geist, V ^a   Richardt, G ^a  

^a Herzzentrum Segeberger Klinken GmbH   (Germany)

^b Diakoniekrankenhaus   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Catecholamines; Ischemia; Myocardial infarction; Neurohumoral factors; Receptors, adrenergic, alpha; Receptors, adrenergic, beta; Reperfusion; Ventricular function

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; ADRENALIN; ALLOPURINOL; ARGIPRESSIN; ATRIAL NATRIURETIC FACTOR; BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; CALCIUM ANTAGONIST; CARVEDILOL; CLOPIDOGREL; DIGITALIS GLYCOSIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN; FIBRINOGEN RECEPTOR ANTAGONIST; HEPARIN DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METOPROLOL; N TERMINAL PROATRIAL NATRIURETIC PEPTIDE; N TERMINAL PROBRAIN NATRIURETIC PEPTIDE; NEUROHORMONE; NITRATE; NORADRENALIN; PROTEIN PRECURSOR; TICLOPIDINE; TROPONIN T; UNCLASSIFIED DRUG; WARFARIN;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; BLOOD PRESSURE; BRADYCARDIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY STENT; DEMOGRAPHY; FEMALE; HEART ARRHYTHMIA; HEART EJECTION FRACTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE WALL MOTION; HEART MUSCLE REPERFUSION; HEART RATE; HEART VENTRICLE TACHYCARDIA; HOLTER MONITORING; HUMAN; HYPOKINESIA; ISCHEMIC HEART DISEASE; KINETICS; MAJOR CLINICAL STUDY; MALE; PAIN; PERCUTANEOUS CORONARY INTERVENTION; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PREOPERATIVE TREATMENT; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT ELEVATION; THROMBUS;

ADMINISTRATION, ORAL; ADRENERGIC BETA-ANTAGONISTS; ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; CARBAZOLES; CHEMOTHERAPY, ADJUVANT; CLINICAL TRIALS; COMORBIDITY; FEMALE; GERMANY; HUMANS; MALE; METOPROLOL; MIDDLE AGED; MYOCARDIAL INFARCTION; PROGNOSIS; PROPANOLAMINES; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT;

EID: 31544446844     PISSN: 18610684     EISSN: 18610692     Source Type: Journal    
DOI: 10.1007/s00392-006-0317-7     Document Type: Article

References (24)

1. The MIAMI Trial Research Group (1985) Metoprolol in acute myocardial infarction (MIAMI). A randomised placebo-controlled international trial. Eur Heart J 6:199-226
2. ISIS-I-Arbeitsgruppe (1986) ISIS-I Collaborative Group (First International Study of Infarct Survival): Randomised trial of intravenous atenolol among 16027 cases of suspected acute myocardial infarction. Lancet 2:57-66
3. Roberts R, Rogers WJ, Müller HS et al (1991) Immediate versus deferred beta-blockade following thrombolytic therapy in patients with acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI) II-B Study. Circulation 83:422-437
4. Basu S, Senior R, Raval U et al (1997) Beneficial effects of intravenous and oral carvedilol treatment in acute myocardial infarction. A placebo-controlled, randomized trial. Circulation 96:183-191
5. Tölg R, Kurz T, Ungerer M et al (1997) Influence of alpha- and beta-adrenoceptor antagonists on ventricular fibrillation in ischemic rat heart. Naunyn-Schmiedeberg's Arch Pharmacol 356:62-68
6. Schäfer U, Kurz T, Jain D et al (2002) Impaired coronary flow and left ventricular dysfunction after mechanical recanalization in acute myocardial infarction: role of neurohumoral activation? Basic Res Cardiol 97:399-408
7. Gregorini L, Marco J, Kozakova M et al (1999) Alpha-adrenergic blockade improves recovery of myocardial perfusion and function after coronary stenting in patients with acute myocardial infarction. Circulation 99:482-490
8. Communal C, Singh K, Sawyer DB et al (1999) Opposing effects of β1- and β2-adrenergic receptros on cardiac myocyte apoptosis. Circulation 100:2210-2212
9. Bril A, Slivjak M, DiMartino M et al (1992) Cardioprotective effects of carvedilol, a novel beta adrenoceptor antagonist with vasodilating properties, in anaesthetised minipigs: comparison with propranolol. Cardiovas Res 26:518-525
10. Feuerstein G, Liu GL, Yue TL et al (1998) Comparison of metoprolol and carvedilol pharmacology and cardioprotection in rabbit ischemia and reperfusion model. Eur J Pharmacol 351:341-350
11. Khandoudi N, Percevault-Albadine J, Bril A (1998) Comparative effects of carvedilol and metoprolol on cardiac ischemia reperfusion injury. J Cardiovasc Pharmacol 32:443-451
12. Gao F, Chen J, Lopez BL et al (2000) Comparision of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model. Eur J Pharmacol 406:109-116
13. Poole-Wilson PA, Swedberg K, Cleland JGF et al (2003) Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet 362:7-13
14. Sheehan FH, Bolson EL, Dodge HT et al (1986) Advantages and applications of the centerline method for characterising regional ventricular function. Circulation 74:293-305
15. Sheehan FH, Doerr R, Schmidt WG et al (1988) Early recovery of left ventricular function after thrombolytic therapy for acute myocardial infarction: an important determinent of survival. J Am Coll Cardiol 12:289-300
16. Sandberg A, Blomqvist I, Jonsson UE et al (1988) Pharmacokinetic and pharmacodynamic properties of a new controlled-release formulation of metoprolol: a comparison with conventional tablets. Eur J Clin Pharmacol 33(Suppl):9-14
17. Neugebauer G, Akpan W, Kaufmann B et al (1990) Stereoselective disposition of carvedilol in man after intravenous and oral administration of the racemic compound. Eur J Clin Pharmacol 38(Suppl 2):108-111
18. Neumann FJ, Blasini R, Schmitt C et al (1998) Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction. Circulation 98:2695-2701
19. + exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA. Circulation 101:2902-2908
20. Marzilli M, Orsini E, Marraccini P et al (2000) Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction. Circulation 101:2154-2159
21. Britten MB, Abolmaali ND, Assmus B et al (2003) Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imaging. Circulation 108:2212-2218
22. Giannitsis E, Müller-Bardorff M, Lehrke S et al (2001) Admission troponin T level predicts clinical outcomes, TIMI flow, and myocardial tissue perfusion after primary percutaneous intervention for acute ST-segment elevation myocardial infarction. Circulation 104:630-635
23. Tanasijevic MJ, Cannon CP, Antman EM et al (1999) Myoglobin, creatine-kinase-MB and cardiac troponin-I 60-minute ratios predict infarct-related artery patency after thrombolysis for acute myocardial infarction: results from the Thrombolysis in Myocardial Infarction study (TIMI) 10B. J Am Coll Cardiol 34:739-747
24. Bolli R (1992) Myocardial stunning in man. Circulation 86:1671-1691