Low urinary placental growth factor is a marker of pre-eclampsia

Kidney International

Volumn 69, Issue 3, 2006, Pages 621-624

  Aggarwal, P K ^a   Jain, V ^a   Sakhuja, V ^a   Karumanchi, S A ^b   Jha, V ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Diagnosis; Placental growth factor; Pre eclampsia; Urinary biomarker

Indexed keywords

CREATININE; PLACENTAL GROWTH FACTOR;

ADULT; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; FETUS GROWTH; HUMAN; LABORATORY TEST; LENGTH OF STAY; MAJOR CLINICAL STUDY; PREDICTION; PREECLAMPSIA; PREGNANT WOMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL;

ADULT; BIOLOGICAL MARKERS; CREATININE; FEMALE; HUMANS; LENGTH OF STAY; PRE-ECLAMPSIA; PREDICTIVE VALUE OF TESTS; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY PROTEINS; PROSPECTIVE STUDIES;

EID: 31544441013     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5000075     Document Type: Article

References (20)

1. Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol 2003; 102: 181-192.
2. Sibai BM, Caritis S, Hauth J. What we have learned about preeclampsia. Semin Perinatol 2003; 27: 239-246.
3. Koga K, Osuga Y, Yoshino O et al. Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia. J Clin Endocrinol Metab 2003; 88: 2348-2351.
4. Levine RJ, Maynard SE, Qian C et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004; 350: 672-683.
5. Maynard SE, Min JY, Merchan J et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111: 649-658.
6. Torry DS, Wang HS, Wang TH et al. Preeclampsia is associated with reduced serum levels of placenta growth factor. Am J Obstet Gynecol 1998; 179: 1539-1544.
7. Tsatsaris V, Goffin F, Munaut C et al. Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences. J Clin Endocrinol Metab 2003; 88: 5555-5563.
8. Zhou Y, Damsky CH, Fisher SJ. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? J Clin Invest 1997; 99: 2152-2164.
9. Thadhani R, Mutter WP, Wolf M et al. First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab 2004; 89: 770-775.
10. Levine RJ, Thadhani R, Qian C et al. Urinary placental growth factor and risk of preeclampsia. JAMA 2005; 293: 77-85.
11. Kendall RL, Thomas KA. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA 1993; 90: 10705-10709.
12. Sugimoto H, Hamano Y, Charytan D et al. Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria. J Biol Chem 2003; 278: 12605-12608.
13. Tjoa ML, van Vugt JM, Mulders MA et al. Plasma placenta growth factor levels in midtrimester pregnancies. Obstet Gynecol 2001; 98: 600-607.
14. Brown LF, Berse B, Tognazzi K et al. Vascular permeability factor mRNA and protein expression in human kidney. Kidney Int 1992; 42: 1457-1461.
15. Simon M, Grone HJ, Johren O et al. Expression of vascular endothelial growth factor and its receptors in human renal ontogenesis and in adult kidney. Am J Physiol 1995; 268: F240-F250.
16. Buhimschi CS, Norwitz ER, Funai E et al. Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia. Am J Obstet Gynecol 2005; 192: 734-741.
17. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999; 13: 9-22.
18. Clark DE, Smith SK, He Y et al. A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation. Biol Reprod 1998; 59: 1540-1548.
19. Sawhney H, Aggarwal N, Biswas R et al. Maternal mortality associated with eclampsia and severe preeclampsia of pregnancy. J Obstet Gynaecol Res 2000; 26: 351-356.
20. The Prevention of Maternal Mortality Network Situation analyses of emergency obstetric care. Examples from eleven operations research projects in West Africa. Soc Sci Med 1995; 40: 657-667.